diff --git a/graalpython/com.oracle.graal.python.cext/CMakeLists.txt b/graalpython/com.oracle.graal.python.cext/CMakeLists.txt
index 346c6fcdd4..8ad41ba7bd 100644
--- a/graalpython/com.oracle.graal.python.cext/CMakeLists.txt
+++ b/graalpython/com.oracle.graal.python.cext/CMakeLists.txt
@@ -381,9 +381,6 @@ set(CTYPES_SRC
     "${SRC_DIR}/modules/_ctypes/ctypes.h"
     "${SRC_DIR}/modules/_ctypes/stgdict.c"
 )
-if(APPLE)
-    set(CTYPES_SRC ${CTYPES_SRC} "${SRC_DIR}/modules/_ctypes/malloc_closure.c")
-endif()
 native_module("_ctypes" TRUE "${CTYPES_SRC}")
 if(WIN32)
     target_compile_definitions("_ctypes" PRIVATE MS_WIN32 MS_WINDOWS)
@@ -434,7 +431,9 @@ elseif(APPLE)
         HAVE_DECL_RTLD_LOCAL
         HAVE_DECL_RTLD_GLOBAL
         HAVE_DYLD_SHARED_CACHE_CONTAINS_PATH
-        USING_MALLOC_CLOSURE_DOT_C
+        HAVE_FFI_CLOSURE_ALLOC
+        HAVE_FFI_PREP_CIF_VAR
+        HAVE_FFI_PREP_CLOSURE_LOC
     )
 else()
     target_compile_definitions("_ctypes" PRIVATE
diff --git a/graalpython/com.oracle.graal.python.test/src/tests/unittest_tags/test_ctypes.txt b/graalpython/com.oracle.graal.python.test/src/tests/unittest_tags/test_ctypes.txt
index 032796088f..9e876d3617 100644
--- a/graalpython/com.oracle.graal.python.test/src/tests/unittest_tags/test_ctypes.txt
+++ b/graalpython/com.oracle.graal.python.test/src/tests/unittest_tags/test_ctypes.txt
@@ -21,7 +21,7 @@ test.test_ctypes.test_arrays.ArrayTestCase.test_subclass @ darwin-arm64,linux-aa
 test.test_ctypes.test_arrays.ArrayTestCase.test_zero_length @ darwin-arm64,linux-aarch64,linux-aarch64-github,linux-x86_64,linux-x86_64-github,win32-AMD64,win32-AMD64-github
 test.test_ctypes.test_as_parameter.AsParamNestedWrapperTestCase.test_byval @ darwin-arm64,linux-aarch64,linux-aarch64-github,linux-x86_64,linux-x86_64-github,win32-AMD64,win32-AMD64-github
 test.test_ctypes.test_as_parameter.AsParamNestedWrapperTestCase.test_callbacks @ linux-aarch64,linux-aarch64-github,linux-x86_64,linux-x86_64-github,win32-AMD64,win32-AMD64-github
-test.test_ctypes.test_as_parameter.AsParamNestedWrapperTestCase.test_callbacks_2 @ linux-aarch64,linux-aarch64-github,linux-x86_64,linux-x86_64-github,win32-AMD64,win32-AMD64-github
+test.test_ctypes.test_as_parameter.AsParamNestedWrapperTestCase.test_callbacks_2 @ darwin-arm64,linux-aarch64,linux-aarch64-github,linux-x86_64,linux-x86_64-github,win32-AMD64,win32-AMD64-github
 test.test_ctypes.test_as_parameter.AsParamNestedWrapperTestCase.test_longlong_callbacks @ linux-aarch64,linux-aarch64-github,linux-x86_64,linux-x86_64-github,win32-AMD64,win32-AMD64-github
 test.test_ctypes.test_as_parameter.AsParamNestedWrapperTestCase.test_pointers @ darwin-arm64,linux-aarch64,linux-aarch64-github,linux-x86_64,linux-x86_64-github,win32-AMD64,win32-AMD64-github
 test.test_ctypes.test_as_parameter.AsParamNestedWrapperTestCase.test_recursive_as_param @ darwin-arm64,linux-aarch64,linux-aarch64-github,linux-x86_64,linux-x86_64-github,win32-AMD64,win32-AMD64-github