diff --git a/Documentation/topics/dpdk/pmd.rst b/Documentation/topics/dpdk/pmd.rst
index caa7d97befb..1f61bddb6ec 100644
--- a/Documentation/topics/dpdk/pmd.rst
+++ b/Documentation/topics/dpdk/pmd.rst
@@ -237,9 +237,12 @@ If not set, the default variance improvement threshold is 25%.
 
 .. note::
 
-    PMD Auto Load Balancing doesn't currently work if queues are assigned
-    cross NUMA as actual processing load could get worse after assignment
-    as compared to what dry run predicts.
+    PMD Auto Load Balancing doesn't request a reassignment if queues are
+    assigned cross NUMA and there are multiple NUMA nodes available for
+    reassignment. This is because reassignment to a different NUMA node could
+    lead to an unpredictable change in processing cycles required for a queue.
+    However, if there is only one cross NUMA node available then a dry run and
+    possible request to reassign may continue as normal.
 
 The minimum time between 2 consecutive PMD auto load balancing iterations can
 also be configured by::
diff --git a/lib/dpif-netdev.c b/lib/dpif-netdev.c
index 816945375bc..29e74ee4341 100644
--- a/lib/dpif-netdev.c
+++ b/lib/dpif-netdev.c
@@ -4887,6 +4887,12 @@ struct rr_numa {
     bool idx_inc;
 };
 
+static size_t
+rr_numa_list_count(struct rr_numa_list *rr)
+{
+    return hmap_count(&rr->numas);
+}
+
 static struct rr_numa *
 rr_numa_list_lookup(struct rr_numa_list *rr, int numa_id)
 {
@@ -5599,10 +5605,14 @@ get_dry_run_variance(struct dp_netdev *dp, uint32_t *core_list,
     for (int i = 0; i < n_rxqs; i++) {
         int numa_id = netdev_get_numa_id(rxqs[i]->port->netdev);
         numa = rr_numa_list_lookup(&rr, numa_id);
+        /* If there is no available pmd on the local numa but there is only one
+         * numa for cross-numa polling, we can estimate the dry run. */
+        if (!numa && rr_numa_list_count(&rr) == 1) {
+            numa = rr_numa_list_next(&rr, NULL);
+        }
         if (!numa) {
-            /* Abort if cross NUMA polling. */
-            VLOG_DBG("PMD auto lb dry run."
-                     " Aborting due to cross-numa polling.");
+            VLOG_DBG("PMD auto lb dry run. Aborting due to "
+                     "multiple numa nodes available for cross-numa polling.");
             goto cleanup;
         }