diff --git a/Lib/test/test_gc.py b/Lib/test/test_gc.py
index dd09643788d62fb..82715bb74710504 100644
--- a/Lib/test/test_gc.py
+++ b/Lib/test/test_gc.py
@@ -1397,6 +1397,31 @@ def __del__(self):
             # empty __dict__.
             self.assertEqual(x, None)
 
+    def test_indirect_calls_with_gc_disabled(self):
+        junk = []
+        i = 0
+        detector = GC_Detector()
+        while not detector.gc_happened:
+            i += 1
+            if i > 10000:
+                self.fail("gc didn't happen after 10000 iterations")
+            junk.append([])  # this will eventually trigger gc
+
+        try:
+            gc.disable()
+            junk = []
+            i = 0
+            detector = GC_Detector()
+            while not detector.gc_happened:
+                i += 1
+                if i > 10000:
+                    break
+                junk.append([])  # this will eventually trigger gc
+
+            self.assertEqual(i, 10001)
+        finally:
+            gc.enable()
+
 
 class PythonFinalizationTests(unittest.TestCase):
     def test_ast_fini(self):
diff --git a/Misc/NEWS.d/next/Core and Builtins/2024-03-11-22-24-59.gh-issue-116604.LCEzAT.rst b/Misc/NEWS.d/next/Core and Builtins/2024-03-11-22-24-59.gh-issue-116604.LCEzAT.rst
new file mode 100644
index 000000000000000..516edfa9e6cedf7
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2024-03-11-22-24-59.gh-issue-116604.LCEzAT.rst	
@@ -0,0 +1,3 @@
+Respect the status of the garbage collector when indirect calls are made via
+:c:func:`PyErr_CheckSignals` and the evaluation breaker. Patch by Pablo
+Galindo
diff --git a/Python/gc.c b/Python/gc.c
index ea3b596d1713dfc..6b3316b642ea9e6 100644
--- a/Python/gc.c
+++ b/Python/gc.c
@@ -1805,6 +1805,10 @@ _PyObject_GC_Link(PyObject *op)
 void
 _Py_RunGC(PyThreadState *tstate)
 {
+    GCState *gcstate = get_gc_state();
+    if (!gcstate->enabled) {
+        return;
+    }
     gc_collect_main(tstate, GENERATION_AUTO, _Py_GC_REASON_HEAP);
 }