diff --git a/.github/workflows/python-dev.yml b/.github/workflows/python-dev.yml
index 3a139936fbd22..b32b18b86e9df 100644
--- a/.github/workflows/python-dev.yml
+++ b/.github/workflows/python-dev.yml
@@ -73,8 +73,6 @@ jobs:
       shell: bash
       run: |
         ci/run_tests.sh
-      # GH 41935
-      continue-on-error: true
 
     - name: Publish test results
       uses: actions/upload-artifact@master
diff --git a/pandas/tests/io/parser/common/test_common_basic.py b/pandas/tests/io/parser/common/test_common_basic.py
index ff54a378806fa..6d958f46a49dd 100644
--- a/pandas/tests/io/parser/common/test_common_basic.py
+++ b/pandas/tests/io/parser/common/test_common_basic.py
@@ -12,6 +12,7 @@
 import numpy as np
 import pytest
 
+from pandas.compat import PY310
 from pandas.errors import (
     EmptyDataError,
     ParserError,
@@ -674,6 +675,11 @@ def test_read_table_equivalency_to_read_csv(all_parsers):
     tm.assert_frame_equal(result, expected)
 
 
+@pytest.mark.skipif(
+    PY310,
+    reason="GH41935 This test is leaking only on Python 3.10,"
+    "causing other tests to fail with a cryptic error.",
+)
 @pytest.mark.parametrize("read_func", ["read_csv", "read_table"])
 def test_read_csv_and_table_sys_setprofile(all_parsers, read_func):
     # GH#41069