diff --git a/pandas/_libs/src/compat_helper.h b/pandas/_libs/src/compat_helper.h
index 8f86bb3f8e62f..73787023c27b7 100644
--- a/pandas/_libs/src/compat_helper.h
+++ b/pandas/_libs/src/compat_helper.h
@@ -26,7 +26,7 @@ the macro, which restores compat.
 https://bugs.python.org/issue29943
 */
 
-#if PY_VERSION_HEX < 0x03070000 && defined(PySlice_GetIndicesEx)
+#if ! defined(PYPY_VERSION) && PY_VERSION_HEX < 0x03070000 && defined(PySlice_GetIndicesEx)
   #undef PySlice_GetIndicesEx
 #endif