diff --git a/pandas/_testing/asserters.py b/pandas/_testing/asserters.py
index 2e5f8c372f7ef..8833f265d5850 100644
--- a/pandas/_testing/asserters.py
+++ b/pandas/_testing/asserters.py
@@ -1105,6 +1105,25 @@ def assert_series_equal(
             index_values=left.index,
             obj=str(obj),
         )
+    elif not check_dtype:
+        left_na = np.asarray(left.isna())
+        right_na = np.asarray(right.isna())
+        assert_numpy_array_equal(
+            left_na, right_na, obj=f"{obj} NA mask", index_values=left.index
+        )
+
+        left_valid = left[~left_na].to_numpy(dtype=object)
+        right_valid = right[~right_na].to_numpy(dtype=object)
+
+        _testing.assert_almost_equal(
+            left_valid,
+            right_valid,
+            check_dtype=False,
+            rtol=rtol,
+            atol=atol,
+            obj=str(obj),
+            index_values=left.index,
+        )
     else:
         _testing.assert_almost_equal(
             left._values,
diff --git a/pandas/tests/util/test_assert_frame_equal.py b/pandas/tests/util/test_assert_frame_equal.py
index 8711365a19214..bceb1af8b711c 100644
--- a/pandas/tests/util/test_assert_frame_equal.py
+++ b/pandas/tests/util/test_assert_frame_equal.py
@@ -5,6 +5,7 @@
 import pandas as pd
 from pandas import DataFrame
 import pandas._testing as tm
+from pandas.testing import assert_frame_equal
 
 
 @pytest.fixture(params=[True, False])
@@ -399,6 +400,7 @@ def test_assert_frame_equal_set_mismatch():
         tm.assert_frame_equal(df1, df2)
 
 
+
 def test_datetimelike_compat_deprecated():
     # GH#55638
     df = DataFrame({"a": [1]})
@@ -413,3 +415,11 @@ def test_datetimelike_compat_deprecated():
         tm.assert_series_equal(df["a"], df["a"], check_datetimelike_compat=True)
     with tm.assert_produces_warning(Pandas4Warning, match=msg):
         tm.assert_series_equal(df["a"], df["a"], check_datetimelike_compat=False)
+
+
+def test_assert_frame_equal_na_object_vs_int32_check_dtype_false():
+    
+    df1 = pd.DataFrame({"x": pd.Series([pd.NA], dtype="Int32")})
+    df2 = pd.DataFrame({"x": pd.Series([pd.NA], dtype="object")})
+    assert_frame_equal(df1, df2, check_dtype=False)
+