diff --git a/doc/source/reference/api/pandas.Series.__invert__.rst b/doc/source/reference/api/pandas.Series.__invert__.rst
new file mode 100644
index 0000000000000..0c82307bca351
--- /dev/null
+++ b/doc/source/reference/api/pandas.Series.__invert__.rst
@@ -0,0 +1,53 @@
+.. currentmodule:: pandas
+
+pandas.Series.__invert__
+========================
+
+Elementwise invert (``~``) for :class:`pandas.Series`.
+
+**Signature**
+
+``Series.__invert__(self) -> Series``
+
+**Summary**
+
+For boolean and nullable-boolean dtypes, ``~s`` toggles the mask
+(``True`` ↔ ``False``) and propagates ``pd.NA``. For integer dtypes,
+``~`` performs bitwise invert as in Python.
+
+.. seealso::
+   :ref:`Boolean indexing <indexing.boolean>`
+
+**Examples**
+
+Boolean / nullable boolean::
+
+    >>> s = pd.Series([True, pd.NA, False], dtype="boolean")
+    >>> ~s
+    0    False
+    1     <NA>
+    2     True
+    dtype: boolean
+
+Integer vs boolean::
+
+    >>> s_int = pd.Series([0, 1, 2], dtype="int64")
+    >>> ~s_int
+    0    -1
+    1    -2
+    2    -3
+    dtype: int64
+
+Arrow-backed boolean (if pyarrow installed)::
+
+    >>> s_arrow = pd.Series([True, pd.NA, False], dtype="boolean[pyarrow]")
+    >>> ~s_arrow
+    0    False
+    1     <NA>
+    2     True
+    dtype: boolean[pyarrow]
+
+**Notes**
+
+- In Python’s stdlib, :func:`operator.__invert__` is bitwise invert on integers.
+  In pandas, ``~`` on boolean arrays is elementwise invert.
diff --git a/doc/source/reference/series.rst b/doc/source/reference/series.rst
index 6006acc8f5e16..a099c48613e21 100644
--- a/doc/source/reference/series.rst
+++ b/doc/source/reference/series.rst
@@ -107,6 +107,14 @@ Binary operator functions
    Series.product
    Series.dot
 
+Unary operator functions
+------------------------
+.. toctree::
+   :maxdepth: 1
+
+   api/pandas.Series.__invert__
+
+
 Function application, GroupBy & window
 --------------------------------------
 .. autosummary::
diff --git a/doc/source/user_guide/indexing.rst b/doc/source/user_guide/indexing.rst
index ebd1791c0f4ad..413ddb7a23155 100644
--- a/doc/source/user_guide/indexing.rst
+++ b/doc/source/user_guide/indexing.rst
@@ -811,6 +811,10 @@ evaluate an expression such as ``df['A'] > 2 & df['B'] < 3`` as
 ``df['A'] > (2 & df['B']) < 3``, while the desired evaluation order is
 ``(df['A'] > 2) & (df['B'] < 3)``.
 
+For toggling boolean masks with the ``~`` operator, see
+:meth:`pandas.Series.__invert__`.
+
+
 Using a boolean vector to index a Series works exactly as in a NumPy ndarray:
 
 .. ipython:: python