diff --git a/tests/python/pants_test/backend/python/tasks/native/test_ctypes_integration.py b/tests/python/pants_test/backend/python/tasks/native/test_ctypes_integration.py
index 4df6d205edb..f8ef8d2e0cc 100644
--- a/tests/python/pants_test/backend/python/tasks/native/test_ctypes_integration.py
+++ b/tests/python/pants_test/backend/python/tasks/native/test_ctypes_integration.py
@@ -110,56 +110,6 @@ def _assert_ctypes_binary_creation(self, toolchain_variant):
       binary_run_output = invoke_pex_for_output(pex)
       self.assertEqual(b'x=3, f(x)=17\n', binary_run_output)
 
-  def test_invalidation_ctypes(self):
-    """Test that the current version of a python_dist() is resolved after modifying its sources."""
-    with temporary_dir() as tmp_dir:
-      with self.mock_buildroot(
-          dirs_to_copy=[self._binary_target_dir]) as buildroot, buildroot.pushd():
-
-        def run_target(goal):
-          return self.run_pants_with_workdir(
-            command=[goal, self._binary_target],
-            workdir=os.path.join(buildroot.new_buildroot, '.pants.d'),
-            build_root=buildroot.new_buildroot,
-            config={
-              GLOBAL_SCOPE_CONFIG_SECTION: {
-                'pants_distdir': tmp_dir,
-              },
-            },
-          )
-
-        output_pex = os.path.join(tmp_dir, 'bin.pex')
-
-        initial_result_message = 'x=3, f(x)=17'
-
-        unmodified_pants_run = run_target('run')
-        self.assert_success(unmodified_pants_run)
-        self.assertIn(initial_result_message, unmodified_pants_run.stdout_data)
-
-        unmodified_pants_binary_create = run_target('binary')
-        self.assert_success(unmodified_pants_binary_create)
-        binary_run_output = invoke_pex_for_output(output_pex).decode('utf-8')
-        self.assertIn(initial_result_message, binary_run_output)
-
-        # Modify one of the source files for this target so that the output is different.
-        cpp_source_file = os.path.join(self._binary_target_dir, 'some_more_math.cpp')
-        with open(cpp_source_file, 'r') as f:
-          orig_contents = f.read()
-        modified_contents = re.sub(r'3', '4', orig_contents)
-        with open(cpp_source_file, 'w') as f:
-          f.write(modified_contents)
-
-        modified_result_message = 'x=3, f(x)=28'
-
-        modified_pants_run = run_target('run')
-        self.assert_success(modified_pants_run)
-        self.assertIn(modified_result_message, modified_pants_run.stdout_data)
-
-        modified_pants_binary_create = run_target('binary')
-        self.assert_success(modified_pants_binary_create)
-        binary_run_output = invoke_pex_for_output(output_pex).decode('utf-8')
-        self.assertIn(modified_result_message, binary_run_output)
-
   def test_ctypes_native_language_interop(self):
     for variant in ToolchainVariant.allowed_values:
       self._assert_ctypes_interop_with_mock_buildroot(variant)