diff --git a/packages/react-core/src/components/Modal/Modal.tsx b/packages/react-core/src/components/Modal/Modal.tsx
index fa83e709cb2..9364a2cf171 100644
--- a/packages/react-core/src/components/Modal/Modal.tsx
+++ b/packages/react-core/src/components/Modal/Modal.tsx
@@ -37,6 +37,10 @@ export interface ModalProps extends React.HTMLProps<HTMLDivElement>, OUIAProps {
   description?: React.ReactNode;
   /** Flag to disable focus trap. */
   disableFocusTrap?: boolean;
+  /** The element to focus when the modal opens. By default the first
+   * focusable element will receive focus.
+   */
+  elementToFocus?: HTMLElement | SVGElement | string;
   /** Custom footer. */
   footer?: React.ReactNode;
   /** Flag indicating if modal content should be placed in a modal box body wrapper. */
@@ -235,6 +239,7 @@ export class Modal extends React.Component<ModalProps, ModalState> {
       ouiaId,
       ouiaSafe,
       position,
+      elementToFocus,
       ...props
     } = this.props;
     const { container } = this.state;
@@ -260,6 +265,7 @@ export class Modal extends React.Component<ModalProps, ModalState> {
         ouiaId={ouiaId !== undefined ? ouiaId : this.state.ouiaStateId}
         ouiaSafe={ouiaSafe}
         position={position}
+        elementToFocus={elementToFocus}
       />,
       container
     ) as React.ReactElement;
diff --git a/packages/react-core/src/components/Modal/ModalContent.tsx b/packages/react-core/src/components/Modal/ModalContent.tsx
index 91fbc158b11..2ae5a134fce 100644
--- a/packages/react-core/src/components/Modal/ModalContent.tsx
+++ b/packages/react-core/src/components/Modal/ModalContent.tsx
@@ -47,6 +47,10 @@ export interface ModalContentProps extends OUIAProps {
   descriptorId: string;
   /** Flag to disable focus trap. */
   disableFocusTrap?: boolean;
+  /** The element to focus when the modal opens. By default the first
+   * focusable element will receive focus.
+   */
+  elementToFocus?: HTMLElement | SVGElement | string;
   /** Custom footer. */
   footer?: React.ReactNode;
   /** Flag indicating if modal content should be placed in a modal box body wrapper. */
@@ -118,6 +122,7 @@ export const ModalContent: React.FunctionComponent<ModalContentProps> = ({
   hasNoBodyWrapper = false,
   ouiaId,
   ouiaSafe = true,
+  elementToFocus,
   ...props
 }: ModalContentProps) => {
   if (!isOpen) {
@@ -202,7 +207,13 @@ export const ModalContent: React.FunctionComponent<ModalContentProps> = ({
     <Backdrop>
       <FocusTrap
         active={!disableFocusTrap}
-        focusTrapOptions={{ clickOutsideDeactivates: true, tabbableOptions: { displayCheck: 'none' } }}
+        focusTrapOptions={{
+          clickOutsideDeactivates: true,
+          tabbableOptions: { displayCheck: 'none' },
+          // FocusTrap's initialFocus can accept false as a value to prevent initial focus.
+          // We want to prevent this in case false is ever passed in.
+          initialFocus: elementToFocus || undefined
+        }}
         className={css(bullsEyeStyles.bullseye)}
       >
         {modalBox}
diff --git a/packages/react-core/src/components/Modal/examples/Modal.md b/packages/react-core/src/components/Modal/examples/Modal.md
index c372ebf24b7..938802eca85 100644
--- a/packages/react-core/src/components/Modal/examples/Modal.md
+++ b/packages/react-core/src/components/Modal/examples/Modal.md
@@ -144,3 +144,11 @@ To submit the form from a button in the modal's footer (outside of the `<Form>`)
 ```ts file="ModalWithForm.tsx"
 
 ```
+
+### Custom focus
+
+Use the `elementToFocus` property to customize which element inside the Modal receives focus when initially opened.
+
+```ts file="./ModalCustomFocus.tsx"
+
+```
diff --git a/packages/react-core/src/components/Modal/examples/ModalCustomFocus.tsx b/packages/react-core/src/components/Modal/examples/ModalCustomFocus.tsx
new file mode 100644
index 00000000000..eb797f7e167
--- /dev/null
+++ b/packages/react-core/src/components/Modal/examples/ModalCustomFocus.tsx
@@ -0,0 +1,38 @@
+import React from 'react';
+import { Modal, Button } from '@patternfly/react-core';
+
+export const ModalCustomFocus: React.FunctionComponent = () => {
+  const [isModalOpen, setIsModalOpen] = React.useState(false);
+
+  const handleModalToggle = (_event: KeyboardEvent | React.MouseEvent) => {
+    setIsModalOpen(!isModalOpen);
+  };
+
+  return (
+    <React.Fragment>
+      <Button variant="primary" onClick={handleModalToggle} ouiaId="ShowBasicModal">
+        Show modal with custom focus
+      </Button>
+      <Modal
+        elementToFocus="#modal-custom-focus-confirm-button"
+        title="Modal with custom focus"
+        isOpen={isModalOpen}
+        onClose={handleModalToggle}
+        actions={[
+          <Button id="modal-custom-focus-confirm-button" key="confirm" variant="primary" onClick={handleModalToggle}>
+            Confirm
+          </Button>,
+          <Button key="cancel" variant="link" onClick={handleModalToggle}>
+            Cancel
+          </Button>
+        ]}
+      >
+        Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore
+        magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo
+        consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla
+        pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est
+        laborum.
+      </Modal>
+    </React.Fragment>
+  );
+};
diff --git a/packages/react-integration/cypress/integration/modal.spec.ts b/packages/react-integration/cypress/integration/modal.spec.ts
index 24c61e72070..d5c08b00dac 100644
--- a/packages/react-integration/cypress/integration/modal.spec.ts
+++ b/packages/react-integration/cypress/integration/modal.spec.ts
@@ -83,4 +83,16 @@ describe('Modal Test', () => {
     cy.get('body').type('{esc}');
     cy.get('.pf-v5-c-modal-box').should('not.exist');
   });
+
+  it('Verify first focusable element receives focus by default', () => {
+    cy.get('#showDefaultModalButton').click();
+    cy.get('.pf-v5-c-modal-box__close > .pf-v5-c-button.pf-m-plain').should('have.focus');
+    cy.get('.pf-v5-c-modal-box__close > .pf-v5-c-button.pf-m-plain').click();
+  });
+
+  it('Verify custom element receives focus', () => {
+    cy.get('#showCustomFocusModalButton').click();
+    cy.get('#modal-custom-focus-confirm-button').should('have.focus');
+    cy.get('#modal-custom-focus-cancel-button').click();
+  });
 });
diff --git a/packages/react-integration/demo-app-ts/src/components/demos/ModalDemo/ModalDemo.tsx b/packages/react-integration/demo-app-ts/src/components/demos/ModalDemo/ModalDemo.tsx
index bdc93870459..24c94181eca 100644
--- a/packages/react-integration/demo-app-ts/src/components/demos/ModalDemo/ModalDemo.tsx
+++ b/packages/react-integration/demo-app-ts/src/components/demos/ModalDemo/ModalDemo.tsx
@@ -15,6 +15,7 @@ interface ModalDemoState {
   isModalCustomEscapeOpen: boolean;
   isModalAlertVariantOpen: boolean;
   customEscapePressed: boolean;
+  isCustomFocusModalOpen: boolean;
 }
 
 export class ModalDemo extends React.Component<React.HTMLProps<HTMLDivElement>, ModalDemoState> {
@@ -31,7 +32,8 @@ export class ModalDemo extends React.Component<React.HTMLProps<HTMLDivElement>,
     isNoHeaderModalOpen: false,
     isModalCustomEscapeOpen: false,
     isModalAlertVariantOpen: false,
-    customEscapePressed: false
+    customEscapePressed: false,
+    isCustomFocusModalOpen: false
   };
 
   handleModalToggle = (_event: KeyboardEvent | React.MouseEvent) => {
@@ -102,6 +104,12 @@ export class ModalDemo extends React.Component<React.HTMLProps<HTMLDivElement>,
     }));
   };
 
+  handleCustomFocusModalToggle = () => {
+    this.setState(({ isCustomFocusModalOpen }) => ({
+      isCustomFocusModalOpen: !isCustomFocusModalOpen
+    }));
+  };
+
   componentDidMount() {
     window.scrollTo(0, 0);
   }
@@ -426,6 +434,43 @@ export class ModalDemo extends React.Component<React.HTMLProps<HTMLDivElement>,
     );
   }
 
+  renderCustomFocusModal() {
+    const { isCustomFocusModalOpen } = this.state;
+
+    return (
+      <Modal
+        elementToFocus="#modal-custom-focus-confirm-button"
+        title="Modal with custom focus"
+        isOpen={isCustomFocusModalOpen}
+        onClose={this.handleCustomFocusModalToggle}
+        actions={[
+          <Button
+            id="modal-custom-focus-confirm-button"
+            key="confirm"
+            variant="primary"
+            onClick={this.handleCustomFocusModalToggle}
+          >
+            Confirm
+          </Button>,
+          <Button
+            id="modal-custom-focus-cancel-button"
+            key="cancel"
+            variant="link"
+            onClick={this.handleCustomFocusModalToggle}
+          >
+            Cancel
+          </Button>
+        ]}
+      >
+        Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore
+        magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo
+        consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla
+        pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est
+        laborum.
+      </Modal>
+    );
+  }
+
   render() {
     const buttonStyle = {
       marginRight: 20,
@@ -505,6 +550,14 @@ export class ModalDemo extends React.Component<React.HTMLProps<HTMLDivElement>,
           <Button style={buttonStyle} variant="primary" onClick={this.handleHelpModalToggle} id="showHelpModalButton">
             Show Help Modal
           </Button>
+          <Button
+            style={buttonStyle}
+            variant="primary"
+            onClick={this.handleCustomFocusModalToggle}
+            id="showCustomFocusModalButton"
+          >
+            Show Custom Focus Modal
+          </Button>
         </div>
         {this.renderModal()}
         {this.renderSmallModal()}
@@ -517,6 +570,7 @@ export class ModalDemo extends React.Component<React.HTMLProps<HTMLDivElement>,
         {this.renderModalWithCustomEscape()}
         {this.renderModalWithAlertVariant()}
         {this.renderHelpModal()}
+        {this.renderCustomFocusModal()}
       </React.Fragment>
     );
   }