diff --git a/.github/workflows/test-changes.yml b/.github/workflows/test-changes.yml
index dc921e42..0aa067e7 100644
--- a/.github/workflows/test-changes.yml
+++ b/.github/workflows/test-changes.yml
@@ -37,8 +37,7 @@ jobs:
     steps:
       - name: Determine what scope of testing is available on ${{ matrix.os }}
         if: |
-          matrix.python >= '3.6' && matrix.python != '3.9' && matrix.python != '3.10' &&
-          (matrix.os != 'windows-latest' || matrix.python == '3.8')
+          (matrix.python >= '3.' ) && ( matrix.os != 'windows-latest' )
         run: |
           echo 'testing=full' >> $GITHUB_ENV
 
@@ -59,7 +58,7 @@ jobs:
       - name: Install test dependencies
         run: |
           python -m pip install --upgrade pip
-          python -m pip install -r requirements-tests.txt
+          python -m pip install --prefer-binary -r requirements-tests.txt
 
       - name: Setup environment variables for remote filesystem testing
         if: matrix.os == 'ubuntu-latest' && matrix.python == '3.8'
@@ -69,7 +68,7 @@ jobs:
           echo "Setup SFTP environment variable to trigger testing in Petl"
           echo 'PETL_TEST_SFTP=sftp://petl:test@localhost:2244/public/' >> $GITHUB_ENV
           echo "::group::Install remote test dependencies"
-          python -m pip install -r requirements-remote.txt
+          python -m pip install --prefer-binary -r requirements-remote.txt
           echo "::endgroup::"
 
       - name: Install optinal test dependencies for mode ${{ env.testing }}
@@ -105,7 +104,7 @@ jobs:
           docker run -it --name postgres -p 5432:5432 -e POSTGRES_DB=petl -e POSTGRES_USER=petl -e POSTGRES_PASSWORD=test -d postgres:latest
           echo "::endgroup::"
           echo "::group::Install database test dependencies"
-          python -m pip install -r requirements-database.txt
+          python -m pip install --prefer-binary -r requirements-database.txt
           echo "::endgroup::"
 
       - name: Setup petl package
@@ -119,10 +118,10 @@ jobs:
         if: env.testing == 'full'
         run: |
           echo "::group::Install extra packages test dependencies"
-          python -m pip install -r requirements-formats.txt
+          python -m pip install --prefer-binary -r requirements-formats.txt
           echo "::endgroup::"
-          echo "::group::Perform doc test execution with coverage"
-          pytest --cov=petl petl
+          echo "::group::Perform doctest-modules execution with coverage"
+          pytest --doctest-modules --cov=petl petl
           echo "::endgroup::"
 
       - name: Coveralls
@@ -154,7 +153,7 @@ jobs:
 
       - name: Install doc generation dependencies
         run: |
-          python -m pip install -r requirements-docs.txt
+          python -m pip install --prefer-binary -r requirements-docs.txt
 
       - name: Setup petl package
         run: python setup.py build
diff --git a/pytest.ini b/pytest.ini
index a8ca65f4..900f846d 100644
--- a/pytest.ini
+++ b/pytest.ini
@@ -1,2 +1,4 @@
 [pytest]
 log_level=DEBUG
+doctest_optionflags = NORMALIZE_WHITESPACE ALLOW_UNICODE
+addopts = --ignore-glob=*_py2.py --ignore-glob=petl/io/db.py
diff --git a/requirements-formats.txt b/requirements-formats.txt
index 4480827d..045f30f0 100644
--- a/requirements-formats.txt
+++ b/requirements-formats.txt
@@ -1,10 +1,12 @@
 Cython<0.29.21,>=0.29.13
-numpy<=1.19.2,>=1.16.4
+numpy<=1.19.2,>=1.16.4 ; python_version < '3.10'
+numpy ; python_version >= '3.10'
 numexpr<=2.7.1,>=2.6.9
 intervaltree==3.0.2
 lxml==4.6.5
 openpyxl==2.6.2
 pandas<=1.1.2,>=0.24.2 ; python_version < '3.9'
+pandas ; python_version >= '3.9'
 tables
 Whoosh==2.7.4
 xlrd==2.0.1
diff --git a/tox.ini b/tox.ini
index 4a3f99e0..683280c7 100644
--- a/tox.ini
+++ b/tox.ini
@@ -4,25 +4,18 @@
 # and then run "tox" from this directory.
 
 [tox]
-envlist = py27, py36, py37, py38, py39, {py36,py37,py38}-docs
-# trick to enable pre-installation of numpy and numexpr
-indexserver =
-    preinstall1 = https://pypi.org/simple
-    preinstall2 = https://pypi.org/simple
+envlist = py27, py36, py37, py38, py39, py310, {py36,py37,py38,py39,py310}-docs
 
 [testenv]
 # get stable output for unordered types
 setenv =
     PYTHONHASHSEED = 42
     py27: PY_MAJOR_VERSION = py2
-    py36,py37,py38,py39: PY_MAJOR_VERSION = py3
+    py36,py37,py38,py39,py310: PY_MAJOR_VERSION = py3
 commands =
     pytest --cov=petl petl
     coverage report -m
 deps =
-    :preinstall1: Cython<=0.29.21,>=0.29.13
-    :preinstall1: numpy<=1.19.2,>=1.16.4
-    :preinstall2: numexpr<=2.7.1,>=2.6.9
     -rrequirements-tests.txt
     -rrequirements-formats.txt
 
@@ -34,10 +27,9 @@ deps =
 commands =
     sphinx-build -W -b html -d {envtmpdir}/doctrees .  {envtmpdir}/html
 
-[testenv:{py36,py37,py38}-doctest]
+[testenv:{py36,py37,py38,py39,py310}-doctest]
 commands =
-    py36,py37,py38: nosetests -v --with-doctest --doctest-options=+NORMALIZE_WHITESPACE petl -I"csv_py2\.py" -I"db\.py"
-
+    py36,py37,py38,py39,py310: pytest --doctest-modules --cov=petl petl
 [testenv:{py36,py37,py38,py39}-dochtml]
 changedir = docs
 deps =