diff --git a/pex/resolve/lock_resolver.py b/pex/resolve/lock_resolver.py
index d48770080..3255ffa91 100644
--- a/pex/resolve/lock_resolver.py
+++ b/pex/resolve/lock_resolver.py
@@ -102,7 +102,7 @@ def __init__(
         self._password_entries = password_entries
         self._cache = cache
         self._build_configuration = attr.evolve(
-            build_configuration, allow_wheels=False, prefer_older_binary=False
+            build_configuration, allow_wheels=False, allow_builds=True, prefer_older_binary=False
         )
         self._pip_version = pip_version
         self._resolver = resolver
diff --git a/tests/integration/test_issue_2389.py b/tests/integration/test_issue_2389.py
new file mode 100644
index 000000000..0ba79c24e
--- /dev/null
+++ b/tests/integration/test_issue_2389.py
@@ -0,0 +1,60 @@
+# Copyright 2024 Pex project contributors.
+# Licensed under the Apache License, Version 2.0 (see LICENSE).
+
+import os.path
+import subprocess
+import sys
+
+from pex.interpreter import PythonInterpreter
+from pex.typing import TYPE_CHECKING
+from testing import PY310, ensure_python_interpreter, run_pex_command
+from testing.cli import run_pex3
+
+if TYPE_CHECKING:
+    from typing import Any
+
+
+def test_lock_use_no_build_wheel(tmpdir):
+    # type: (Any)-> None
+
+    lock = os.path.join(str(tmpdir), "black.lock")
+    run_pex3(
+        "lock",
+        "create",
+        "black==22.8.0",
+        "-o",
+        lock,
+        "--style",
+        "universal",
+        "--indent",
+        "2",
+        "--interpreter-constraint",
+        "CPython==3.10.*",
+        "--wheel",
+        "--no-build",
+    ).assert_success()
+
+    pex = os.path.join(str(tmpdir), "black.pex")
+    python = sys.executable if sys.version_info[:2] == (3, 10) else ensure_python_interpreter(PY310)
+    run_pex_command(
+        args=[
+            "-o",
+            pex,
+            "--python",
+            python,
+            "-c",
+            "black",
+            "--lock",
+            lock,
+            "--wheel",
+            "--no-build",
+        ]
+    ).assert_success()
+
+    output = subprocess.check_output(args=[pex, "--version"])
+    assert (
+        "black.pex, 22.8.0 (compiled: {compiled})".format(
+            compiled="no" if PythonInterpreter.from_binary(python).is_pypy else "yes"
+        )
+        in output.decode("utf-8").splitlines()
+    )