diff --git a/system-variables.md b/system-variables.md
index 927207fe5a4df..4463ede235600 100644
--- a/system-variables.md
+++ b/system-variables.md
@@ -546,6 +546,7 @@ mysql> SHOW GLOBAL VARIABLES LIKE 'max_prepared_stmt_count';
 
 - Setting this variable to `ON` requires you to connect to TiDB from a session that has TLS enabled. This helps prevent lock-out scenarios when TLS is not configured correctly.
 - This setting was previously a `tidb.toml` option (`security.require-secure-transport`), but changed to a system variable starting from TiDB v6.1.0.
+- For v6.5.6 or later 6.5 versions, when Security Enhanced Mode (SEM) is enabled, setting this variable to `ON` is prohibited to avoid potential connectivity issues for users.
 
 ### skip_name_resolve <span class="version-mark">New in v5.2.0</span>