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- Cambridge, UK
Code for paper published in March, 2017 analysing the role of de novo mutations in severe developmental disorders (part of the deciphering developmental disorders project).
Calculating change in binding affinity for predicted TF binding sites as a result of de novo mutations in non-coding regions. Uses JASPAR database for TF binding prediction.
Using Weighted Gene Coexpression Network Analysis (WGNCA) to analyze microarray data for correlations between gene modules (groups of genes with similar expression profiles) and phenotypes.
Mutability adjusted proportion of singletons calculation using synonymous SNPs from the DDD unaffected parents.