diff --git a/Cargo.lock b/Cargo.lock
index dfa9263..9be044b 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -681,9 +681,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3"
-version = "0.25.1"
+version = "0.26.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "8970a78afe0628a3e3430376fc5fd76b6b45c4d43360ffd6cdd40bdde72b682a"
+checksum = "7ba0117f4212101ee6544044dae45abe1083d30ce7b29c4b5cbdfa2354e07383"
 dependencies = [
  "indoc",
  "libc",
@@ -698,9 +698,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-async-runtimes"
-version = "0.25.0"
+version = "0.26.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d73cc6b1b7d8b3cef02101d37390dbdfe7e450dfea14921cae80a9534ba59ef2"
+checksum = "e6ee6d4cb3e8d5b925f5cdb38da183e0ff18122eb2048d4041c9e7034d026e23"
 dependencies = [
  "futures",
  "once_cell",
@@ -711,19 +711,18 @@ dependencies = [
 
 [[package]]
 name = "pyo3-build-config"
-version = "0.25.1"
+version = "0.26.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "458eb0c55e7ece017adeba38f2248ff3ac615e53660d7c71a238d7d2a01c7598"
+checksum = "4fc6ddaf24947d12a9aa31ac65431fb1b851b8f4365426e182901eabfb87df5f"
 dependencies = [
- "once_cell",
  "target-lexicon",
 ]
 
 [[package]]
 name = "pyo3-ffi"
-version = "0.25.1"
+version = "0.26.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7114fe5457c61b276ab77c5055f206295b812608083644a5c5b2640c3102565c"
+checksum = "025474d3928738efb38ac36d4744a74a400c901c7596199e20e45d98eb194105"
 dependencies = [
  "libc",
  "pyo3-build-config",
@@ -731,9 +730,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros"
-version = "0.25.1"
+version = "0.26.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "a8725c0a622b374d6cb051d11a0983786448f7785336139c3c94f5aa6bef7e50"
+checksum = "2e64eb489f22fe1c95911b77c44cc41e7c19f3082fc81cce90f657cdc42ffded"
 dependencies = [
  "proc-macro2",
  "pyo3-macros-backend",
@@ -743,9 +742,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros-backend"
-version = "0.25.1"
+version = "0.26.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "4109984c22491085343c05b0dbc54ddc405c3cf7b4374fc533f5c3313a572ccc"
+checksum = "100246c0ecf400b475341b8455a9213344569af29a3c841d29270e53102e0fcf"
 dependencies = [
  "heck",
  "proc-macro2",
diff --git a/Cargo.toml b/Cargo.toml
index ea607d7..5f5e25d 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -31,8 +31,8 @@ http-rewriter = { git = "ssh://git@github.com/platformatic/http-rewriter" }
 # Default enable napi4 feature, see https://nodejs.org/api/n-api.html#node-api-version-matrix
 napi = { version = "3", default-features = false, features = ["napi4", "tokio_rt", "async"], optional = true }
 napi-derive = { version = "3", optional = true }
-pyo3 = { version = "0.25.1", features = ["experimental-async"] }
-pyo3-async-runtimes = { version = "0.25.0", features = ["tokio-runtime"] }
+pyo3 = { version = "0.26.0", features = ["experimental-async"] }
+pyo3-async-runtimes = { version = "0.26.0", features = ["tokio-runtime"] }
 thiserror = "2.0.12"
 tokio = { version = "1.45.1", features = ["full"] }
 libc = "0.2"
diff --git a/src/asgi/http.rs b/src/asgi/http.rs
index cfa7420..cb9de67 100644
--- a/src/asgi/http.rs
+++ b/src/asgi/http.rs
@@ -527,8 +527,8 @@ mod tests {
 
   #[test]
   fn test_http_connection_scope_into_pyobject() {
-    pyo3::prepare_freethreaded_python();
-    Python::with_gil(|py| {
+    Python::initialize();
+    Python::attach(|py| {
       let scope = HttpConnectionScope {
         http_version: HttpVersion::V1_1,
         method: HttpMethod::Get,
@@ -577,8 +577,8 @@ mod tests {
 
   #[test]
   fn test_http_receive_message_into_pyobject() {
-    pyo3::prepare_freethreaded_python();
-    Python::with_gil(|py| {
+    Python::initialize();
+    Python::attach(|py| {
       let message = HttpReceiveMessage::Request {
         body: vec![1, 2, 3],
         more_body: true,
@@ -596,8 +596,8 @@ mod tests {
 
   #[test]
   fn test_http_send_message_from_pyobject() {
-    pyo3::prepare_freethreaded_python();
-    Python::with_gil(|py| {
+    Python::initialize();
+    Python::attach(|py| {
       let dict = PyDict::new(py);
       dict.set_item("type", "http.response.start").unwrap();
       dict.set_item("status", 200).unwrap();
diff --git a/src/asgi/http_method.rs b/src/asgi/http_method.rs
index 55a9eda..35166bb 100644
--- a/src/asgi/http_method.rs
+++ b/src/asgi/http_method.rs
@@ -119,7 +119,7 @@ mod tests {
 
   #[test]
   fn test_http_method_pyobject_conversion() {
-    Python::with_gil(|py| {
+    Python::attach(|py| {
       let tests = vec![
         (HttpMethod::Get, "GET"),
         (HttpMethod::Post, "POST"),
diff --git a/src/asgi/http_version.rs b/src/asgi/http_version.rs
index dc6a705..d5302a1 100644
--- a/src/asgi/http_version.rs
+++ b/src/asgi/http_version.rs
@@ -71,7 +71,7 @@ mod tests {
 
   #[test]
   fn test_http_version_pyobject_conversion() {
-    Python::with_gil(|py| {
+    Python::attach(|py| {
       let tests = vec![
         (HttpVersion::V1_0, "1.0"),
         (HttpVersion::V1_1, "1.1"),
diff --git a/src/asgi/info.rs b/src/asgi/info.rs
index 55bbead..de07f6b 100644
--- a/src/asgi/info.rs
+++ b/src/asgi/info.rs
@@ -73,7 +73,7 @@ mod tests {
 
   #[test]
   fn test_asgi_info_pyobject_conversion() {
-    Python::with_gil(|py| {
+    Python::attach(|py| {
       let asgi_info = AsgiInfo::new("3.0", "2.5");
 
       // Convert AsgiInfo to PyObject
diff --git a/src/asgi/lifespan.rs b/src/asgi/lifespan.rs
index cccb3ec..61c0490 100644
--- a/src/asgi/lifespan.rs
+++ b/src/asgi/lifespan.rs
@@ -107,7 +107,7 @@ mod tests {
 
   #[test]
   fn test_lifespan_scope_into_pyobject() {
-    Python::with_gil(|py| {
+    Python::attach(|py| {
       let lifespan_scope = LifespanScope { state: None };
       let py_obj = lifespan_scope.into_pyobject(py).unwrap();
       assert_eq!(
@@ -129,7 +129,7 @@ mod tests {
 
   #[test]
   fn test_lifespan_receive_message_into_pyobject() {
-    Python::with_gil(|py| {
+    Python::attach(|py| {
       let message = LifespanReceiveMessage::LifespanStartup;
       let py_obj = message.into_pyobject(py).unwrap();
       assert_eq!(
@@ -148,7 +148,7 @@ mod tests {
 
   #[test]
   fn test_lifespan_send_message_from_pyobject() {
-    Python::with_gil(|py| {
+    Python::attach(|py| {
       let dict = PyDict::new(py);
       dict.set_item("type", "lifespan.shutdown.complete").unwrap();
       let message: LifespanSendMessage = dict.extract().unwrap();
@@ -163,7 +163,7 @@ mod tests {
 
   #[test]
   fn test_lifespan_send_message_from_pyobject_error_cases() {
-    Python::with_gil(|py| {
+    Python::attach(|py| {
       // Test missing 'type' key
       let dict = PyDict::new(py);
       let result: Result<LifespanSendMessage, _> = dict.extract();
@@ -261,7 +261,7 @@ mod tests {
 
   #[test]
   fn test_lifespan_scope_with_populated_state() {
-    Python::with_gil(|py| {
+    Python::attach(|py| {
       // Create a state dictionary with some data
       let state_dict = PyDict::new(py);
       state_dict.set_item("initialized", true).unwrap();
diff --git a/src/asgi/mod.rs b/src/asgi/mod.rs
index 05b8a69..01aa427 100644
--- a/src/asgi/mod.rs
+++ b/src/asgi/mod.rs
@@ -62,12 +62,12 @@ pub use websocket::{
 
 /// Handle to a shared Python event loop
 pub struct EventLoopHandle {
-  event_loop: PyObject,
+  event_loop: Py<PyAny>,
 }
 
 impl EventLoopHandle {
   /// Get the Python event loop object
-  pub fn event_loop(&self) -> &PyObject {
+  pub fn event_loop(&self) -> &Py<PyAny> {
     &self.event_loop
   }
 }
@@ -75,7 +75,7 @@ impl EventLoopHandle {
 impl Drop for EventLoopHandle {
   fn drop(&mut self) {
     // Stop the Python event loop when the last handle is dropped
-    Python::with_gil(|py| {
+    Python::attach(|py| {
       if let Err(e) = self.event_loop.bind(py).call_method0("stop") {
         eprintln!("Failed to stop Python event loop: {e}");
       }
@@ -111,10 +111,10 @@ fn create_event_loop_handle() -> Result<EventLoopHandle, HandlerError> {
   ensure_python_symbols_global();
 
   // Initialize Python if not already initialized
-  pyo3::prepare_freethreaded_python();
+  Python::initialize();
 
   // Create event loop
-  let event_loop = Python::with_gil(|py| -> Result<PyObject, HandlerError> {
+  let event_loop = Python::attach(|py| -> Result<Py<PyAny>, HandlerError> {
     let asyncio = py.import("asyncio")?;
     let event_loop = asyncio.call_method0("new_event_loop")?;
     let event_loop_py = event_loop.unbind();
@@ -139,7 +139,7 @@ pub struct Asgi {
   // Shared Python event loop handle
   event_loop_handle: Arc<EventLoopHandle>,
   // ASGI app function
-  app_function: PyObject,
+  app_function: Py<PyAny>,
 }
 
 unsafe impl Send for Asgi {}
@@ -160,7 +160,7 @@ impl Asgi {
     let event_loop_handle = ensure_python_event_loop()?;
 
     // Load Python app
-    let app_function = Python::with_gil(|py| -> Result<PyObject, HandlerError> {
+    let app_function = Python::attach(|py| -> Result<Py<PyAny>, HandlerError> {
       // Load and compile Python module
       let entrypoint = docroot
         .join(format!("{}.py", target.file))
@@ -241,7 +241,7 @@ impl Handler for Asgi {
     tokio::spawn(collect_response_messages(tx_receiver, response_tx));
 
     // Submit the ASGI app call to Python event loop
-    Python::with_gil(|py| {
+    Python::attach(|py| {
       let scope_py = scope.into_pyobject(py)?;
       let coro = self
         .app_function
@@ -361,8 +361,8 @@ fn setup_python_paths(py: Python, docroot: &Path) -> PyResult<()> {
 }
 
 /// Start a Python thread that runs the event loop forever
-fn start_python_event_loop_thread(event_loop: PyObject) {
-  Python::with_gil(|py| {
+fn start_python_event_loop_thread(event_loop: Py<PyAny>) {
+  Python::attach(|py| {
     // Set the event loop for this thread and run it
     let asyncio = py.import("asyncio")?;
     asyncio.call_method1("set_event_loop", (event_loop.bind(py),))?;
diff --git a/src/asgi/receiver.rs b/src/asgi/receiver.rs
index c82b058..e8c9622 100644
--- a/src/asgi/receiver.rs
+++ b/src/asgi/receiver.rs
@@ -50,7 +50,7 @@ impl Receiver {
       ReceiverType::Http(rx) => {
         let message = rx.lock().await.recv().await;
         if let Some(msg) = message {
-          Python::with_gil(|py| Ok(msg.into_pyobject(py)?.unbind()))
+          Python::attach(|py| Ok(msg.into_pyobject(py)?.unbind()))
         } else {
           Err(PyValueError::new_err("No message received"))
         }
@@ -58,7 +58,7 @@ impl Receiver {
       ReceiverType::WebSocket(rx) => {
         let message = rx.lock().await.recv().await;
         if let Some(msg) = message {
-          Python::with_gil(|py| Ok(msg.into_pyobject(py)?.unbind()))
+          Python::attach(|py| Ok(msg.into_pyobject(py)?.unbind()))
         } else {
           Err(PyValueError::new_err("No message received"))
         }
@@ -66,7 +66,7 @@ impl Receiver {
       ReceiverType::Lifespan(rx) => {
         let message = rx.lock().await.recv().await;
         if let Some(msg) = message {
-          Python::with_gil(|py| Ok(msg.into_pyobject(py)?.unbind()))
+          Python::attach(|py| Ok(msg.into_pyobject(py)?.unbind()))
         } else {
           Err(PyValueError::new_err("No message received"))
         }
diff --git a/src/asgi/sender.rs b/src/asgi/sender.rs
index 3e8dd2f..602eeb6 100644
--- a/src/asgi/sender.rs
+++ b/src/asgi/sender.rs
@@ -52,12 +52,12 @@ impl Sender {
 
 #[pymethods]
 impl Sender {
-  async fn __call__(&mut self, args: Py<PyDict>) -> PyResult<PyObject> {
+  async fn __call__(&mut self, args: Py<PyDict>) -> PyResult<Py<PyAny>> {
     // Create acknowledgment channel
     let (ack_tx, ack_rx) = oneshot::channel::<()>();
 
     // Send message with acknowledgment channel
-    let send_result: PyResult<()> = Python::with_gil(|py| {
+    let send_result: PyResult<()> = Python::attach(|py| {
       let args_dict = args.bind(py);
       match &self.0 {
         SenderType::Http(tx) => {
@@ -95,7 +95,7 @@ impl Sender {
 
     // Wait for acknowledgment
     match ack_rx.await {
-      Ok(()) => Python::with_gil(|py| Ok(py.None())),
+      Ok(()) => Python::attach(|py| Ok(py.None())),
       Err(_) => Err(PyValueError::new_err("message not acknowledged")),
     }
   }
diff --git a/src/asgi/websocket.rs b/src/asgi/websocket.rs
index 84a0d34..b2aa8fd 100644
--- a/src/asgi/websocket.rs
+++ b/src/asgi/websocket.rs
@@ -302,7 +302,7 @@ mod tests {
 
   #[test]
   fn test_websocket_connection_scope_into_pyobject() {
-    Python::with_gil(|py| {
+    Python::attach(|py| {
       let scope = WebSocketConnectionScope {
         http_version: HttpVersion::V2_0,
         scheme: "ws".to_string(),
@@ -353,7 +353,7 @@ mod tests {
 
   #[test]
   fn test_websocket_receive_message_into_pyobject() {
-    Python::with_gil(|py| {
+    Python::attach(|py| {
       let connect_msg = WebSocketReceiveMessage::Connect;
       let dict = connect_msg.into_pyobject(py).unwrap();
       assert_eq!(
@@ -398,7 +398,7 @@ mod tests {
 
   #[test]
   fn test_websocket_send_message_from_pyobject() {
-    Python::with_gil(|py| {
+    Python::attach(|py| {
       let dict = PyDict::new(py);
       dict.set_item("type", "websocket.accept").unwrap();
       dict.set_item("subprotocol", "chat").unwrap();