From c304b7134b336ac98bc73e1e663b984b1ada0bcd Mon Sep 17 00:00:00 2001 From: Zakariyya Mughal Date: Sun, 3 Oct 2021 23:13:09 -0400 Subject: [PATCH] Add note about Cys S-S bond frequency in proteome --- doc/development/open-questions/index.mdwn | 13 +++++++++++-- 1 file changed, 11 insertions(+), 2 deletions(-) diff --git a/doc/development/open-questions/index.mdwn b/doc/development/open-questions/index.mdwn index 7a60b305c..afed0f999 100644 --- a/doc/development/open-questions/index.mdwn +++ b/doc/development/open-questions/index.mdwn @@ -69,5 +69,14 @@ Discussion of metacognitive strategies that could have computer aides. + algorithm: etymology? + http://etym.org/ - Discuss phenomenon in terms of statistical distributions: - * Make note of how frequent a phenonmenon occurs. A particular - phenomenon could be important in terms of its effects, but rare. + * Make note of how frequent a phenomenon occurs. A particular + phenomenon could be important in terms of its effects, but rare. For + example, a [[disulfide bridge (SS bond)|https://en.wikipedia.org/wiki/Disulfide]] + between cysteine (Cys) amino acids is important for the stability of proteins, + but per analysis of a *H. sapiens* proteome DB in + [[Cysteines and Disulfide Bonds as Structure-Forming Units: Insights From Different Domains of Life and the Potential for Characterization by NMR|https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191308/]], + Cys is found in 97% of proteins, but disulfide bonds are only marked in + 18% of proteins, but there is also another effect of protein length that is + correlated with the presence of a disulfide bond. Further information on this: + + [[Frequency of cysteine residue in proteins - Human Homo sapiens - BNID 103538|https://bionumbers.hms.harvard.edu/bionumber.aspx?s=n&v=2&id=103538]] + + [[Occurrence of protein disulfide bonds in different domains of life: a comparison of proteins from the Protein Data Bank - Protein Engineering, Design and Selection - Oxford Academic|https://academic.oup.com/peds/article/27/3/65/1518881]]