A Rust library for variant calling using a latent variable model.
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README.md

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A Rust library for calling genomic variants using a latent variable model. This library is under active development. A preprint describing an early version of the model can be found here: https://doi.org/10.1101/121954.

Authors

Model

  • Johannes Köster (sampling probability, indel allele probabilities, FDR control, prior probabilities)
  • Louis Dijkstra (latent variable model)
  • David Lähnemann (single cell whole genome amplification model, single cell & bulk joint calling model / event setup)
  • Alexander Schönhuth (latent variable model, single cell whole genome amplification model, single cell & bulk joint calling model / event setup)

Implementation

  • Johannes Köster (framework, software architecture, model, tumor-normal variant calling)
  • David Lähnemann (single cell variant calling, FDR on Event sets) with strong support from Johannes Köster

Supervision

Affiliations

Affiliations during work on the project: