biasedsignaling.rst

Biased signaling

Data submission

Submission of biased ligands, balanced reference ligands and pathway effects

• Definitions: For definitions on biased ligands, see the IUPHAR community guidelines for GPCR ligand bias
• Support: In case you need further help, please write to info@gpcrdb.org.
• GPCRdb: Your data will be deposited in the next, monthly update of GPCRdb.

Biased ligands

Please submit your ligands tested for bias (even those found to be unbiased) using this annotation file. The file contains pop up explanations and example data, which you can replace with your data.

Balanced ligands (references for pathway-bias)

Please submit your balanced reference ligands (have near-equal signaling in two compared pathways as defined in a bias plot) using annotation file. The file contains pop up explanations and example data, which you can replace with your data. The balanced reference ligands will be used to calculate ligand pathway-bias and avail ligands with pathway-bias in GPCRdb.

Pathway effects

Please submit your data on pathway effects using this annotation file. The file contains pop up explanations and example data, which you can replace with your data.