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Mutation browser

This video demonstrates how use the mutation browser to search for and visualize mutations for a family of receptors.

  • It is possible to limit the search to a particular part of the sequence, e.g. TM6.
  • The mutations are listed in table format, and it is possible to filter and order interactions by the values in each column.
  • By moving the pointer to a ligand name or reference, more details can be shown.
  • Snake and Helix box plots highlighting the mutated residues can be downloaded. The mutated residues are colored on a green-yellow-red scale according to effect on ligand binding.
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  • Look up mutations for histamine receptors. How many are available for generic position 3x32?
  • Look up mutations for your favorite family of GPCRs. How many are available?