diff --git a/pybricksdev/ble/pybricks.py b/pybricksdev/ble/pybricks.py
index cb058b9..d33bdf4 100644
--- a/pybricksdev/ble/pybricks.py
+++ b/pybricksdev/ble/pybricks.py
@@ -328,6 +328,12 @@ def _standard_uuid(short: int) -> str:
 .. availability:: Since Pybricks protocol v1.0.0.
 """
 
+DEVICE_NAME_UUID = _standard_uuid(0x2A00)
+"""Standard Device Name UUID
+
+.. availability:: Since Pybricks protocol v1.0.0.
+"""
+
 FW_REV_UUID = _standard_uuid(0x2A26)
 """Standard Firmware Revision String characteristic UUID
 
diff --git a/pybricksdev/connections/pybricks.py b/pybricksdev/connections/pybricks.py
index e481812..e1e4013 100644
--- a/pybricksdev/connections/pybricks.py
+++ b/pybricksdev/connections/pybricks.py
@@ -8,6 +8,7 @@
 import os
 import struct
 from typing import Awaitable, Callable, List, Optional, Tuple, TypeVar
+from uuid import UUID
 
 import reactivex.operators as op
 import semver
@@ -19,9 +20,15 @@
 from tqdm.auto import tqdm
 from tqdm.contrib.logging import logging_redirect_tqdm
 
+from usb.control import get_descriptor
+from usb.core import Device as USBDevice
+from usb.core import Endpoint, USBTimeoutError
+from usb.util import ENDPOINT_IN, ENDPOINT_OUT, endpoint_direction, find_descriptor
+
 from ..ble.lwp3.bytecodes import HubKind
 from ..ble.nus import NUS_RX_UUID, NUS_TX_UUID
 from ..ble.pybricks import (
+    DEVICE_NAME_UUID,
     FW_REV_UUID,
     PNP_ID_UUID,
     PYBRICKS_COMMAND_EVENT_UUID,
@@ -38,6 +45,7 @@
 from ..compile import compile_file, compile_multi_file
 from ..tools import chunk
 from ..tools.checksum import xor_bytes
+from ..usb import LegoUsbPid
 from . import ConnectionState
 
 logger = logging.getLogger(__name__)
@@ -138,6 +146,158 @@ def handler(_, data):
         await self._client.start_notify(NUS_TX_UUID, handler)
 
 
+class _USBTransport(_Transport):
+    _device: USBDevice
+    _disconnected_callback: Callable
+    _ep_in: Endpoint
+    _ep_out: Endpoint
+    _notify_callbacks = {}
+    _monitor_task: asyncio.Task
+    _response_event = asyncio.Event()
+    _response: int
+
+    _USB_PYBRICKS_MSG_COMMAND = b"\x00"
+    _USB_PYBRICKS_MSG_COMMAND_RESPONSE = b"\x01"
+    _USB_PYBRICKS_MSG_EVENT = b"\x02"
+
+    def __init__(self, device: USBDevice):
+        self._device = device
+        self._notify_callbacks[
+            self._USB_PYBRICKS_MSG_COMMAND_RESPONSE[0]
+        ] = self._response_handler
+
+    async def connect(self, disconnected_callback: Callable) -> None:
+        self._disconnected_callback = disconnected_callback
+        self._device.set_configuration()
+
+        # Save input and output endpoints
+        cfg = self._device.get_active_configuration()
+        intf = cfg[(0, 0)]
+        self._ep_in = find_descriptor(
+            intf,
+            custom_match=lambda e: endpoint_direction(e.bEndpointAddress)
+            == ENDPOINT_IN,
+        )
+        self._ep_out = find_descriptor(
+            intf,
+            custom_match=lambda e: endpoint_direction(e.bEndpointAddress)
+            == ENDPOINT_OUT,
+        )
+
+        # Get length of BOS descriptor
+        bos_descriptor = get_descriptor(self._device, 5, 0x0F, 0)
+        (ofst, bos_len) = struct.unpack("<BxHx", bos_descriptor)
+
+        # Get full BOS descriptor
+        bos_descriptor = get_descriptor(self._device, bos_len, 0x0F, 0)
+
+        while ofst < bos_len:
+            (len, desc_type, cap_type) = struct.unpack_from(
+                "<BBB", bos_descriptor, offset=ofst
+            )
+
+            if desc_type != 0x10:
+                raise Exception("Expected Device Capability descriptor")
+
+            # Look for platform descriptors
+            if cap_type == 0x05:
+                uuid_bytes = bos_descriptor[ofst + 4 : ofst + 4 + 16]
+                uuid_str = str(UUID(bytes_le=bytes(uuid_bytes)))
+
+                if uuid_str == DEVICE_NAME_UUID:
+                    self._device_name = bytes(
+                        bos_descriptor[ofst + 20 : ofst + len]
+                    ).decode()
+                    print("Connected to hub '" + self._device_name + "'")
+
+                elif uuid_str == FW_REV_UUID:
+                    fw_version = bytes(bos_descriptor[ofst + 20 : ofst + len])
+                    self._fw_version = Version(fw_version.decode())
+
+                elif uuid_str == SW_REV_UUID:
+                    protocol_version = bytes(bos_descriptor[ofst + 20 : ofst + len])
+                    self._protocol_version = semver.VersionInfo.parse(
+                        protocol_version.decode()
+                    )
+
+                elif uuid_str == PYBRICKS_HUB_CAPABILITIES_UUID:
+                    caps = bytes(bos_descriptor[ofst + 20 : ofst + len])
+                    (
+                        self._max_write_size,
+                        self._capability_flags,
+                        self._max_user_program_size,
+                    ) = unpack_hub_capabilities(caps)
+
+            ofst += len
+
+        self._monitor_task = asyncio.create_task(self._monitor_usb())
+
+    async def disconnect(self) -> None:
+        # FIXME: Need to make sure this is called when the USB cable is unplugged
+        self._monitor_task.cancel()
+        self._disconnected_callback()
+
+    async def get_firmware_version(self) -> Version:
+        return self._fw_version
+
+    async def get_protocol_version(self) -> Version:
+        return self._protocol_version
+
+    async def get_hub_type(self) -> Tuple[HubKind, int]:
+        hub_types = {
+            LegoUsbPid.SPIKE_PRIME: (HubKind.TECHNIC_LARGE, 0),
+            LegoUsbPid.ROBOT_INVENTOR: (HubKind.TECHNIC_LARGE, 1),
+            LegoUsbPid.SPIKE_ESSENTIAL: (HubKind.TECHNIC_SMALL, 0),
+        }
+
+        return hub_types[self._device.idProduct]
+
+    async def get_hub_capabilities(self) -> Tuple[int, HubCapabilityFlag, int]:
+        return (
+            self._max_write_size,
+            self._capability_flags,
+            self._max_user_program_size,
+        )
+
+    async def send_command(self, command: bytes) -> None:
+        self._response = None
+        self._response_event.clear()
+        self._ep_out.write(self._USB_PYBRICKS_MSG_COMMAND + command)
+        try:
+            await asyncio.wait_for(self._response_event.wait(), 1)
+            if self._response != 0:
+                print(f"Received error response for command: {self._response}")
+        except asyncio.TimeoutError:
+            print("Timed out waiting for a response")
+
+    async def set_service_handler(self, callback: Callable) -> None:
+        self._notify_callbacks[self._USB_PYBRICKS_MSG_EVENT[0]] = callback
+
+    async def _monitor_usb(self):
+        loop = asyncio.get_running_loop()
+
+        while True:
+            msg = await loop.run_in_executor(None, self._read_usb)
+
+            if msg is None or len(msg) == 0:
+                continue
+
+            if msg[0] in self._notify_callbacks:
+                callback = self._notify_callbacks[msg[0]]
+                callback(bytes(msg[1:]))
+
+    def _read_usb(self):
+        try:
+            msg = self._ep_in.read(self._ep_in.wMaxPacketSize)
+            return msg
+        except USBTimeoutError:
+            return None
+
+    def _response_handler(self, data: bytes) -> None:
+        (self._response,) = struct.unpack("<I", data)
+        self._response_event.set()
+
+
 class PybricksHub:
     EOL = b"\r\n"  # MicroPython EOL
 
@@ -326,11 +486,12 @@ def _pybricks_service_handler(self, data: bytes) -> None:
             if self._enable_line_handler:
                 self._handle_line_data(payload)
 
-    async def connect(self, device: BLEDevice):
+    async def connect(self, device):
         """Connects to a device that was discovered with :meth:`pybricksdev.ble.find_device`
+        or :meth:`usb.core.find`
 
         Args:
-            device: The device to connect to.
+            device: The device to connect to (`BLEDevice` or `USBDevice`).
 
         Raises:
             BleakError: if connecting failed (or old firmware without Device
@@ -350,7 +511,12 @@ async def connect(self, device: BLEDevice):
                 self.connection_state_observable.on_next, ConnectionState.DISCONNECTED
             )
 
-            self._transport = _BLETransport(device)
+            if isinstance(device, BLEDevice):
+                self._transport = _BLETransport(device)
+            elif isinstance(device, USBDevice):
+                self._transport = _USBTransport(device)
+            else:
+                raise TypeError("Unsupported device type")
 
             def handle_disconnect():
                 logger.info("Disconnected!")