diff --git a/pydantic/_internal/_model_construction.py b/pydantic/_internal/_model_construction.py
index 15dbb3ee1c..4fa66925e1 100644
--- a/pydantic/_internal/_model_construction.py
+++ b/pydantic/_internal/_model_construction.py
@@ -587,8 +587,39 @@ def generate_model_signature(
     return Signature(parameters=list(merged_params.values()), return_annotation=None)
 
 
-class _PydanticWeakRef(weakref.ReferenceType):
-    pass
+class _PydanticWeakRef:
+    """Wrapper for `weakref.ref` that enables `pickle` serialization.
+
+    Cloudpickle fails to serialize `weakref.ref` objects due to an arcane error related
+    to abstract base classes (`abc.ABC`). This class works around the issue by wrapping
+    `weakref.ref` instead of subclassing it.
+
+    See https://github.com/pydantic/pydantic/issues/6763 for context.
+
+    Semantics:
+        - If not pickled, behaves the same as a `weakref.ref`.
+        - If pickled along with the referenced object, the same `weakref.ref` behavior
+          will be maintained between them after unpickling.
+        - If pickled without the referenced object, after unpickling the underlying
+          reference will be cleared (`__call__` will always return `None`).
+    """
+
+    def __init__(self, obj: Any):
+        if obj is None:
+            # The object will be `None` upon deserialization if the serialized weakref
+            # had lost its underlying object.
+            self._wr = None
+        else:
+            self._wr = weakref.ref(obj)
+
+    def __call__(self) -> Any:
+        if self._wr is None:
+            return None
+        else:
+            return self._wr()
+
+    def __reduce__(self) -> tuple[Callable, tuple[weakref.ReferenceType | None]]:
+        return _PydanticWeakRef, (self(),)
 
 
 def build_lenient_weakvaluedict(d: dict[str, Any] | None) -> dict[str, Any] | None:
diff --git a/tests/test_pickle_pydantic_weakref.py b/tests/test_pickle_pydantic_weakref.py
new file mode 100644
index 0000000000..bba590d8d3
--- /dev/null
+++ b/tests/test_pickle_pydantic_weakref.py
@@ -0,0 +1,52 @@
+import gc
+import pickle
+
+from pydantic._internal._model_construction import _PydanticWeakRef
+
+
+class IntWrapper:
+    def __init__(self, v: int):
+        self._v = v
+
+    def get(self) -> int:
+        return self._v
+
+    def __eq__(self, other: 'IntWrapper') -> bool:
+        return self.get() == other.get()
+
+
+def test_pickle_pydantic_weakref():
+    obj1 = IntWrapper(1)
+    ref1 = _PydanticWeakRef(obj1)
+    assert ref1() is obj1
+
+    obj2 = IntWrapper(2)
+    ref2 = _PydanticWeakRef(obj2)
+    assert ref2() is obj2
+
+    ref3 = _PydanticWeakRef(IntWrapper(3))
+    gc.collect()  # PyPy does not use reference counting and always relies on GC.
+    assert ref3() is None
+
+    d = {
+        # Hold a hard reference to the underlying object for ref1 that will also
+        # be pickled.
+        'hard_ref': obj1,
+        # ref1's underlying object has a hard reference in the pickled object so it
+        # should maintain the reference after deserialization.
+        'has_hard_ref': ref1,
+        # ref2's underlying object has no hard reference in the pickled object so it
+        # should be `None` after deserialization.
+        'has_no_hard_ref': ref2,
+        # ref3's underlying object had already gone out of scope before pickling so it
+        # should be `None` after deserialization.
+        'ref_out_of_scope': ref3,
+    }
+
+    loaded = pickle.loads(pickle.dumps(d))
+    gc.collect()  # PyPy does not use reference counting and always relies on GC.
+
+    assert loaded['hard_ref'] == IntWrapper(1)
+    assert loaded['has_hard_ref']() is loaded['hard_ref']
+    assert loaded['has_no_hard_ref']() is None
+    assert loaded['ref_out_of_scope']() is None