diff --git a/PyInstaller/depend/bindepend.py b/PyInstaller/depend/bindepend.py
index f2e63e265a..153278e760 100644
--- a/PyInstaller/depend/bindepend.py
+++ b/PyInstaller/depend/bindepend.py
@@ -616,6 +616,7 @@ def _getImports_macholib(pth):
     from macholib.MachO import MachO
     from macholib.mach_o import LC_RPATH
     from macholib.dyld import dyld_find
+    from macholib.util import in_system_path
     rslt = set()
     seen = set()  # Libraries read from binary headers.
 
@@ -711,7 +712,12 @@ def _getImports_macholib(pth):
                 lib = dyld_find(lib, executable_path=exec_path)
                 rslt.add(lib)
             except ValueError:
-                logger.error('Can not find path %s (needed by %s)', lib, pth)
+                # Starting with Big Sur, system libraries are hidden. And
+                # we do not collect system libraries on any macOS version
+                # anyway, so suppress the corresponding error messages.
+                if not in_system_path(lib):
+                    logger.error('Can not find path %s (needed by %s)',
+                                 lib, pth)
 
     return rslt
 
diff --git a/news/5107.bugfix.rst b/news/5107.bugfix.rst
new file mode 100644
index 0000000000..f3d087c851
--- /dev/null
+++ b/news/5107.bugfix.rst
@@ -0,0 +1,3 @@
+(OSX) Suppress missing library error messages for system libraries as
+those are never collected by PyInstaller and starting with Big Sur,
+they are hidden by the OS.