Here are articles that describe how to set up Google App Engine with a Pyjamas application. The first 2 articles focus on the tricky/scary/oo-er aspects of deploying static HTML files on GAE. If you are completely new to GAE, start with Charles Law's (clawcoder) blog post which gives a quick overview of how GAE works. The last article, Amund's, focuses on setting up GAE to do JSONRPC. JSONRPC is an important part of the pyjamas mindset, as it is the primary method of communication.