diff --git a/MANIFEST.in b/MANIFEST.in
index 799a3f0bb2..9561fb1061 100644
--- a/MANIFEST.in
+++ b/MANIFEST.in
@@ -1,9 +1 @@
-prune .github
-prune doc
-prune tests
-exclude .*
-exclude ChangeLog
-exclude pylintrc
-exclude README.rst
-exclude requirements_*.txt
-exclude tox.ini
+include README.rst
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 0000000000..ae1d97446c
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,55 @@
+[build-system]
+requires = ["setuptools~=62.6", "wheel~=0.37.1"]
+build-backend = "setuptools.build_meta"
+
+[project]
+name        = "astroid"
+license     = {text = "LGPL-2.1-or-later"}
+description = "An abstract syntax tree for Python with inference support."
+readme      = "README.rst"
+authors     = [
+    {name = "Python Code Quality Authority", email = "code-quality@python.org"}
+]
+keywords    = ["static code analysis", "python", "abstract syntax tree"]
+classifiers = [
+    "Development Status :: 6 - Mature",
+    "Environment :: Console",
+    "Intended Audience :: Developers",
+    "License :: OSI Approved :: GNU Lesser General Public License v2 (LGPLv2)",
+    "Operating System :: OS Independent",
+    "Programming Language :: Python",
+    "Programming Language :: Python :: 3",
+    "Programming Language :: Python :: 3 :: Only",
+    "Programming Language :: Python :: 3.7",
+    "Programming Language :: Python :: 3.8",
+    "Programming Language :: Python :: 3.9",
+    "Programming Language :: Python :: 3.10",
+    "Programming Language :: Python :: Implementation :: CPython",
+    "Programming Language :: Python :: Implementation :: PyPy",
+    "Topic :: Software Development :: Libraries :: Python Modules",
+    "Topic :: Software Development :: Quality Assurance",
+    "Topic :: Software Development :: Testing",
+]
+requires-python = ">=3.7.2"
+dependencies = [
+    "lazy_object_proxy>=1.4.0",
+    "wrapt>=1.11,<2",
+    "typed-ast>=1.4.0,<2.0;implementation_name=='cpython' and python_version<'3.8'",
+    "typing-extensions>=3.10;python_version<'3.10'",
+]
+dynamic = ["version"]
+
+[project.urls]
+"Docs"           = "https://pylint.pycqa.org/projects/astroid/en/latest/"
+"Source Code"    = "https://github.com/PyCQA/astroid"
+"Bug tracker"    = "https://github.com/PyCQA/astroid/issues"
+"Discord server" = "https://discord.gg/Egy6P8AMB5"
+
+[tool.setuptools]
+license-files = ["LICENSE", "CONTRIBUTORS.txt"]  # Keep in sync with setup.cfg
+
+[tool.setuptools.packages.find]
+include = ["astroid*"]
+
+[tool.setuptools.dynamic]
+version = {attr = "astroid.__pkginfo__.__version__"}
diff --git a/setup.cfg b/setup.cfg
index b1943a12ae..eeb978244c 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -1,51 +1,12 @@
+# Setuptools v62.6 doesn't support editable installs with just 'pyproject.toml' (PEP 660).
+# Keep this file until it does!
+
 [metadata]
-name = astroid
-description = An abstract syntax tree for Python with inference support.
-version = attr: astroid.__pkginfo__.__version__
-long_description = file: README.rst
-long_description_content_type = text/x-rst
-url = https://github.com/PyCQA/astroid
-author = Python Code Quality Authority
-author_email = code-quality@python.org
-license = LGPL-2.1-or-later
+# wheel doesn't yet read license_files from pyproject.toml - tools.setuptools
+# Keep it here until it does!
 license_files =
     LICENSE
     CONTRIBUTORS.txt
-classifiers =
-    Development Status :: 6 - Mature
-    Environment :: Console
-    Intended Audience :: Developers
-    License :: OSI Approved :: GNU Lesser General Public License v2 (LGPLv2)
-    Operating System :: OS Independent
-    Programming Language :: Python
-    Programming Language :: Python :: 3
-    Programming Language :: Python :: 3 :: Only
-    Programming Language :: Python :: 3.7
-    Programming Language :: Python :: 3.8
-    Programming Language :: Python :: 3.9
-    Programming Language :: Python :: 3.10
-    Programming Language :: Python :: Implementation :: CPython
-    Programming Language :: Python :: Implementation :: PyPy
-    Topic :: Software Development :: Libraries :: Python Modules
-    Topic :: Software Development :: Quality Assurance
-    Topic :: Software Development :: Testing
-keywords = static code analysis,python,abstract syntax tree
-project_urls =
-    Bug tracker = https://github.com/PyCQA/astroid/issues
-    Discord server = https://discord.gg/Egy6P8AMB5
-
-[options]
-packages = find:
-install_requires =
-    lazy_object_proxy>=1.4.0
-    wrapt>=1.11,<2
-    typed-ast>=1.4.0,<2.0;implementation_name=="cpython" and python_version<"3.8"
-    typing-extensions>=3.10;python_version<"3.10"
-python_requires = >=3.7.2
-
-[options.packages.find]
-include =
-    astroid*
 
 [aliases]
 test = pytest
@@ -63,6 +24,11 @@ known_first_party = astroid
 include_trailing_comma = True
 skip_glob = tests/testdata
 
+[flake8]
+# Required for flake8-typing-imports (v1.12.0)
+# The plugin doesn't yet read the value from pyproject.toml
+min_python_version = 3.7.2
+
 [mypy]
 scripts_are_modules = True
 no_implicit_optional = True
diff --git a/setup.py b/setup.py
index 606849326a..46bbfefdbc 100644
--- a/setup.py
+++ b/setup.py
@@ -1,3 +1,2 @@
-from setuptools import setup
-
-setup()
+# Keep until dependabot issue is resolved
+# https://github.com/dependabot/dependabot-core/issues/4483