diff --git a/doc/whatsnew/fragments/5327.false_positive b/doc/whatsnew/fragments/5327.false_positive
new file mode 100644
index 0000000000..6751a4619d
--- /dev/null
+++ b/doc/whatsnew/fragments/5327.false_positive
@@ -0,0 +1,3 @@
+Don't emit ``used-before-assignment`` in pattern matching with a guard.
+
+Closes #5327
diff --git a/pylint/checkers/variables.py b/pylint/checkers/variables.py
index 9efb9e1be6..5973b7db01 100644
--- a/pylint/checkers/variables.py
+++ b/pylint/checkers/variables.py
@@ -30,6 +30,7 @@
 )
 from pylint.constants import (
     PY39_PLUS,
+    PY310_PLUS,
     TYPING_NEVER,
     TYPING_NORETURN,
     TYPING_TYPE_CHECKS_GUARDS,
@@ -1694,6 +1695,10 @@ def _check_consumer(
                 if not (
                     self._postponed_evaluation_enabled
                     and isinstance(stmt, (nodes.AnnAssign, nodes.FunctionDef))
+                ) and not (
+                    PY310_PLUS
+                    and isinstance(stmt, nodes.Match)
+                    and isinstance(node.parent, nodes.Compare)
                 ):
                     self.add_message(
                         "used-before-assignment",
diff --git a/pylint/constants.py b/pylint/constants.py
index d9ff20c466..aca5dec4a4 100644
--- a/pylint/constants.py
+++ b/pylint/constants.py
@@ -18,6 +18,7 @@
 
 PY38_PLUS = sys.version_info[:2] >= (3, 8)
 PY39_PLUS = sys.version_info[:2] >= (3, 9)
+PY310_PLUS = sys.version_info[:2] >= (3, 10)
 
 IS_PYPY = platform.python_implementation() == "PyPy"