diff --git a/news/12580.feature.rst b/news/12580.feature.rst
new file mode 100644
index 00000000000..a96279f6794
--- /dev/null
+++ b/news/12580.feature.rst
@@ -0,0 +1 @@
+Add packse scenarios as pip tests
diff --git a/tests/functional/test_resolve_packse.py b/tests/functional/test_resolve_packse.py
new file mode 100644
index 00000000000..f2bde263688
--- /dev/null
+++ b/tests/functional/test_resolve_packse.py
@@ -0,0 +1,166 @@
+import json
+import subprocess
+import sys
+import time
+from typing import Any, Dict, Generator, List
+
+import pytest
+
+from tests.lib import PipTestEnvironment
+
+ambigious_prerelease_resolution = (
+    "Spec is ambigious, and uv and pip do not agree: "
+    "https://github.com/astral-sh/packse/issues/160"
+)
+requires_different_python_version = (
+    "Don't support this test yet with the way pip tests work. Probably "
+    "need some kind of support from packse, written up a couple of "
+    "issues that would allow it to be supported: "
+    "https://github.com/astral-sh/packse/issues/164 "
+    "https://github.com/astral-sh/packse/issues/163"
+)
+not_served_as_yanked = (
+    "There seems to be an issue with packse serve right now where "
+    "yanked packages are not showing as yanked in the simple api: "
+    "https://github.com/astral-sh/packse/issues/165"
+)
+
+EXPECTED_TO_FAIL = {
+    "example": (
+        "Expected solution looks wrong: "
+        "https://github.com/astral-sh/packse/issues/157"
+    ),
+    "local-not-used-with-sdist": (
+        "Tests that sdist versions are preferred over local versions. "
+        "Discussed: https://github.com/astral-sh/packse/issues/158. "
+        "TODO: Find if this is a known issue on pip and/or packaging"
+    ),
+    "local-transitive-confounding": (
+        "Expected solution looks wrong: "
+        "https://github.com/astral-sh/packse/issues/159"
+    ),
+    "transitive-prerelease-and-stable-dependency": (ambigious_prerelease_resolution),
+    "transitive-prerelease-and-stable-dependency-many-versions": (
+        ambigious_prerelease_resolution
+    ),
+    "transitive-package-only-prereleases-in-range-opt-in": (
+        ambigious_prerelease_resolution
+    ),
+    "package-only-prereleases-boundary": (
+        "Expected solution is probably wrong: "
+        "https://github.com/astral-sh/packse/issues/161"
+    ),
+    "package-prereleases-specifier-boundary": (requires_different_python_version),
+    "python-greater-than-current": (requires_different_python_version),
+    "python-greater-than-current-patch": (requires_different_python_version),
+    "python-greater-than-current-backtrack": (requires_different_python_version),
+    "python-greater-than-current-excluded": (requires_different_python_version),
+    "compatible-python-incompatible-override": (requires_different_python_version),
+    "incompatible-python-compatible-override-unavailable-no-wheels": (
+        requires_different_python_version
+    ),
+    "incompatible-python-compatible-override-no-compatible-wheels": (
+        requires_different_python_version
+    ),
+    "incompatible-python-compatible-override-other-wheel": (
+        requires_different_python_version
+    ),
+    "python-patch-override-no-patch": (requires_different_python_version),
+    "package-only-yanked": (not_served_as_yanked),
+    "package-only-yanked-in-range": (not_served_as_yanked),
+    "requires-package-yanked-and-unyanked-any": (not_served_as_yanked),
+    "package-yanked-specified-mixed-available": (not_served_as_yanked),
+    "transitive-package-only-yanked": (not_served_as_yanked),
+    "transitive-package-only-yanked-in-range": (not_served_as_yanked),
+    "transitive-yanked-and-unyanked-dependency": (not_served_as_yanked),
+}
+
+
+def run_command(command: List[str], cwd: None = None) -> str:
+    result = subprocess.run(command, cwd=cwd, capture_output=True, text=True)
+    result.check_returncode()
+    return result.stdout.strip()
+
+
+@pytest.fixture(scope="session", autouse=True)
+def start_packse_server() -> Generator[None, None, None]:
+    """Starts the packse server before tests run and ensures it's terminated after."""
+    proc = subprocess.Popen(
+        ["packse", "serve", "--host", "127.0.0.1", "--port", "3141"]
+    )
+    time.sleep(1)
+    yield
+    proc.terminate()
+
+
+def pytest_generate_tests(metafunc: pytest.Metafunc) -> None:
+    """Dynamically parameterize tests based on scenarios fetched from packse."""
+
+    if sys.version_info < (3, 12):
+        return
+
+    if "scenario" in metafunc.fixturenames:
+        # Fetch scenarios using packse
+        run_command(["packse", "fetch", "--force"])
+
+        # Inspect scenarios using packse
+        scenarios_json: str = run_command(["packse", "inspect", "scenarios"])
+        scenarios = json.loads(scenarios_json)
+
+        # Prepare scenarios for parameterization, marking some as XFAIL
+        scenarios_for_param = []
+        ids_for_param = []
+        for scenario in scenarios["scenarios"]:
+            if scenario["name"] in EXPECTED_TO_FAIL:
+                mark = pytest.mark.xfail(reason=EXPECTED_TO_FAIL[scenario["name"]])
+                scenario_data = pytest.param(scenario, marks=mark)
+            else:
+                scenario_data = scenario
+            scenarios_for_param.append(scenario_data)
+            ids_for_param.append(scenario["name"])
+
+        # Parameterize the test function with the prepared scenarios and IDs
+        metafunc.parametrize("scenario", scenarios_for_param, ids=ids_for_param)
+
+
+@pytest.mark.network
+@pytest.mark.skipif(sys.version_info < (3, 12), reason="requires Python 3.12 or higher")
+def test_packse_scenario(script: PipTestEnvironment, scenario: Dict[str, Any]) -> None:
+    """Dynamically generated test for each packse scenario."""
+    expected_satisfiable: bool = scenario["expected"]["satisfiable"]
+    requirements: list[str] = [r["requirement"] for r in scenario["root"]["requires"]]
+
+    resolver_options = []
+    if scenario["resolver_options"]["prereleases"]:
+        resolver_options.append("--pre")
+    if scenario["resolver_options"]["no_build"]:
+        resolver_options.append("--only-binary")
+        resolver_options.append(",".join(scenario["resolver_options"]["no_build"]))
+    if scenario["resolver_options"]["no_binary"]:
+        resolver_options.append("--no-binary")
+        resolver_options.append(",".join(scenario["resolver_options"]["no_binary"]))
+
+    # Install the package as per the scenario setup
+    result = script.pip(
+        "install",
+        "--index-url=http://127.0.0.1:3141/simple",
+        *resolver_options,
+        *requirements,
+        allow_error=True,
+    )
+
+    resolution_failure_message = (
+        "ERROR: Could not find a version that satisfies the requirement",
+        "ERROR: ResolutionImpossible",
+        "ERROR: Cannot install",
+        "requires a different Python:",
+    )
+
+    if expected_satisfiable:
+        assert "ERROR" not in result.stderr
+        expected_installed = {
+            p["name"]: p["version"] for p in scenario["expected"]["packages"]
+        }
+        script.assert_installed(**expected_installed)
+    else:
+        assert any(error in result.stderr for error in resolution_failure_message)
diff --git a/tests/requirements.txt b/tests/requirements.txt
index 84b7c14d4b4..b86f810c009 100644
--- a/tests/requirements.txt
+++ b/tests/requirements.txt
@@ -1,6 +1,7 @@
 cryptography
 freezegun
 installer
+packse[serve] ; python_version >= '3.12'
 pytest
 pytest-cov
 pytest-rerunfailures