diff --git a/pytestqt/_tests/test_wait_signal.py b/pytestqt/_tests/test_wait_signal.py
index addfbfbd..99cba4ea 100644
--- a/pytestqt/_tests/test_wait_signal.py
+++ b/pytestqt/_tests/test_wait_signal.py
@@ -217,9 +217,8 @@ def check(self, timeout, *delays):
     return StopWatch()
 
 
-@pytest.mark.parametrize('multiple, raising',
-                         [(True, True), (True, False), (False, True),
-                          (False, False)])
+@pytest.mark.parametrize('multiple', [True, False])
+@pytest.mark.parametrize('raising', [True, False])
 def test_wait_signals_handles_exceptions(qtbot, multiple, raising):
     """
     Make sure waitSignal handles exceptions correctly.
@@ -239,3 +238,30 @@ class TestException(Exception):
     with pytest.raises(TestException):
         with func(arg, timeout=10, raising=raising):
             raise TestException
+
+
+@pytest.mark.parametrize('multiple', [True, False])
+@pytest.mark.parametrize('do_timeout', [True, False])
+def test_wait_twice(qtbot, single_shot, multiple, do_timeout):
+    """
+    https://github.com/pytest-dev/pytest-qt/issues/69
+    """
+    signaller = Signaller()
+
+    if multiple:
+        func = qtbot.waitSignals
+        arg = [signaller.signal]
+    else:
+        func = qtbot.waitSignal
+        arg = signaller.signal
+
+    if do_timeout:
+        with func(arg, timeout=100):
+            single_shot(signaller.signal, 200)
+        with func(arg, timeout=100):
+            single_shot(signaller.signal, 200)
+    else:
+        with func(arg):
+            signaller.signal.emit()
+        with func(arg):
+            signaller.signal.emit()
diff --git a/pytestqt/plugin.py b/pytestqt/plugin.py
index 7ca92883..377b0e99 100644
--- a/pytestqt/plugin.py
+++ b/pytestqt/plugin.py
@@ -355,6 +355,12 @@ def __init__(self, timeout=1000, raising=False):
         self.timeout = timeout
         self.signal_triggered = False
         self.raising = raising
+        if timeout is None:
+            self._timer = None
+        else:
+            self._timer = QtCore.QTimer()
+            self._timer.setSingleShot(True)
+            self._timer.setInterval(timeout)
 
     def wait(self):
         """
@@ -367,13 +373,26 @@ def wait(self):
             return
         if self.timeout is None and not self._signals:
             raise ValueError("No signals or timeout specified.")
-        if self.timeout is not None:
-            QtCore.QTimer.singleShot(self.timeout, self._loop.quit)
+        if self._timer is not None:
+            self._timer.timeout.connect(self._quit_loop_by_timeout)
+            self._timer.start()
         self._loop.exec_()
         if not self.signal_triggered and self.raising:
             raise SignalTimeoutError("Didn't get signal after %sms." %
                                       self.timeout)
 
+    def _quit_loop_by_timeout(self):
+        self._loop.quit()
+        self._cleanup()
+
+    def _cleanup(self):
+        if self._timer is not None:
+            try:
+                self._timer.timeout.disconnect(self._quit_loop_by_timeout)
+            except (TypeError, RuntimeError):
+                # already disconnected by Qt?
+                pass
+
     def __enter__(self):
         return self
 
@@ -426,6 +445,16 @@ def _quit_loop_by_signal(self):
         """
         self.signal_triggered = True
         self._loop.quit()
+        self._cleanup()
+
+    def _cleanup(self):
+        super(SignalBlocker, self)._cleanup()
+        for signal in self._signals:
+            try:
+                signal.disconnect(self._quit_loop_by_signal)
+            except (TypeError, RuntimeError):
+                # already disconnected by Qt?
+                pass
 
 
 class MultiSignalBlocker(_AbstractSignalBlocker):