diff --git a/.gitignore b/.gitignore
index aa45f946fa7..242f50845a2 100644
--- a/.gitignore
+++ b/.gitignore
@@ -6,6 +6,7 @@ __pycache__/
 *.so
 
 # Distribution / packaging
+.eggs/
 .Python
 env/
 bin/
@@ -69,3 +70,11 @@ docs/_build/
 #OS
 .DS_Store
 
+# JetBrains
+.idea
+
+# Extra test images installed from pillow-depends/test_images
+Tests/images/README.md
+Tests/images/msp
+Tests/images/picins
+Tests/images/sunraster
diff --git a/.travis/install.sh b/.travis/install.sh
index 694a460e919..8d5e973fb46 100755
--- a/.travis/install.sh
+++ b/.travis/install.sh
@@ -8,11 +8,12 @@ sudo apt-get -qq install libfreetype6-dev liblcms2-dev python-tk\
              libharfbuzz-dev libfribidi-dev
 
 pip install cffi
-pip install nose
 pip install check-manifest
+pip install coverage
 pip install olefile
+pip install -U pytest
+pip install -U pytest-cov
 pip install pyroma
-pip install coverage
 
 # docs only on Python 2.7
 if [ "$TRAVIS_PYTHON_VERSION" == "2.7" ]; then pip install -r requirements.txt ; fi
diff --git a/.travis/script.sh b/.travis/script.sh
index e1d52212273..1473ab07925 100755
--- a/.travis/script.sh
+++ b/.travis/script.sh
@@ -6,8 +6,8 @@ coverage erase
 python setup.py clean
 CFLAGS="-coverage" python setup.py build_ext --inplace
 
-coverage run --append --include=PIL/* selftest.py
-coverage run --append --include=PIL/* -m nose -vx Tests/test_*.py
+python selftest.py
+python setup.py test
 pushd /tmp/check-manifest && check-manifest --ignore ".coveragerc,.editorconfig,*.yml,*.yaml,tox.ini" && popd
 
 # Docs
diff --git a/Makefile b/Makefile
index d27afaa0bb3..7d9d3447205 100644
--- a/Makefile
+++ b/Makefile
@@ -15,12 +15,9 @@ co:
     done
 
 coverage:
-	coverage erase
-	coverage run --parallel-mode --include=PIL/* selftest.py
-	nosetests --with-cov --cov='PIL/' --cov-report=html Tests/test_*.py
-# Doesn't combine properly before report, writing report instead of displaying invalid report.
+	python selftest.py
+	python setup.py test
 	rm -r htmlcov || true
-	coverage combine
 	coverage report
 
 doc:
@@ -81,7 +78,7 @@ release-test:
 	$(MAKE) install-req
 	python setup.py develop
 	python selftest.py
-	nosetests Tests/test_*.py
+	python -m pytest Tests
 	python setup.py install
 	python test-installed.py
 	check-manifest
@@ -92,7 +89,7 @@ sdist:
 	python setup.py sdist --format=gztar
 
 test:
-	python test-installed.py
+	pytest -qq
 
 # https://docs.python.org/2/distutils/packageindex.html#the-pypirc-file
 upload-test:
diff --git a/Tests/README.rst b/Tests/README.rst
index 0985e0f260c..f0118c62941 100644
--- a/Tests/README.rst
+++ b/Tests/README.rst
@@ -8,7 +8,7 @@ Dependencies
 
 Install::
 
-    pip install coverage nose
+    pip install pytest pytest-cov
 
 Execution
 ---------
@@ -21,12 +21,11 @@ To run an individual test::
 
 Run all the tests from the root of the Pillow source distribution::
 
-    nosetests -vx Tests/test_*.py
+    pytest -vx Tests
 
 Or with coverage::
 
-    coverage run --append --include=PIL/* -m nose -vx Tests/test_*.py
-    coverage report
+    pytest -vx --cov PIL --cov-report term Tests
     coverage html
     open htmlcov/index.html
 
@@ -39,6 +38,3 @@ To run an individual test::
 Run all the tests from the root of the Pillow source distribution::
 
     ./test-installed.py
-
-
-
diff --git a/Tests/helper.py b/Tests/helper.py
index 1375eb7e5dd..609db153623 100644
--- a/Tests/helper.py
+++ b/Tests/helper.py
@@ -42,8 +42,9 @@ def delete_tempfile(self, path):
         try:
             ok = self.currentResult.wasSuccessful()
         except AttributeError:  # for nosetests
-            proxy = self.currentResult
-            ok = (len(proxy.errors) + len(proxy.failures) == 0)
+            # proxy = self.currentResult
+            # ok = (len(proxy.errors) + len(proxy.failures) == 0)
+            ok = True  # TODO pytest
 
         if ok:
             # only clean out tempfiles if test passed
@@ -180,7 +181,7 @@ class PillowLeakTestCase(PillowTestCase):
     # requires unix/osx
     iterations = 100 # count
     mem_limit = 512 # k
-    
+
     def _get_mem_usage(self):
         """
         Gets the RUSAGE memory usage, returns in K. Encapsulates the difference
@@ -188,7 +189,7 @@ def _get_mem_usage(self):
 
         :returns; memory usage in kilobytes
         """
-        
+
         from resource import getpagesize, getrusage, RUSAGE_SELF
         mem = getrusage(RUSAGE_SELF).ru_maxrss
         if sys.platform == 'darwin':
@@ -199,7 +200,7 @@ def _get_mem_usage(self):
             # linux
             # man 2 getrusage
             #        ru_maxrss (since Linux 2.6.32)
-            #  This is the maximum resident set size used (in  kilobytes). 
+            #  This is the maximum resident set size used (in kilobytes).
             return mem # Kb
 
     def _test_leak(self, core):
diff --git a/appveyor.yml b/appveyor.yml
index d966c88ffef..94886c8b62e 100644
--- a/appveyor.yml
+++ b/appveyor.yml
@@ -74,8 +74,13 @@ build_script:
 
 test_script:
 - cd c:\pillow
-- '%PYTHON%\%PIP_DIR%\pip.exe install nose'
-- '%PYTHON%\%EXECUTABLE% test-installed.py -v -s %TEST_OPTIONS%'
+- '%PYTHON%\%PIP_DIR%\pip.exe install pytest pytest-cov'
+- '%PYTHON%\%EXECUTABLE% -m pytest -vx --cov PIL --cov-report term --cov-report xml Tests'
+#- '%PYTHON%\%EXECUTABLE% test-installed.py -v -s %TEST_OPTIONS%' TODO TEST_OPTIONS with pytest?
+
+after_test:
+- pip install codecov
+- codecov --file coverage.xml --name %PYTHON%
 
 matrix:
   fast_finish: true
diff --git a/profile-installed.py b/profile-installed.py
deleted file mode 100755
index e3a04c21cb8..00000000000
--- a/profile-installed.py
+++ /dev/null
@@ -1,25 +0,0 @@
-#!/usr/bin/env python
-import os
-import sys
-import glob
-
-import profile
-
-# monkey with the path, removing the local directory but adding the Tests/
-# directory for helper.py and the other local imports there.
-
-del(sys.path[0])
-sys.path.insert(0, os.path.abspath('./Tests'))
-
-# if there's no test selected (mostly) choose a working default.
-# Something is required, because if we import the tests from the local
-# directory, once again, we've got the non-installed PIL in the way
-if len(sys.argv) == 1:
-    sys.argv.extend(glob.glob('Tests/test*.py'))
-
-# Make sure that nose doesn't muck with our paths.
-if ('--no-path-adjustment' not in sys.argv) and ('-P' not in sys.argv):
-    sys.argv.insert(1, '--no-path-adjustment')
-
-if __name__ == '__main__':
-    profile.run("nose.main()", sort=2)
diff --git a/requirements.txt b/requirements.txt
index 213f145ab09..4cb3c090704 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -11,10 +11,10 @@ docutils
 jarn.viewdoc
 Jinja2
 MarkupSafe
-nose
-nose-cov
 olefile
 pycodestyle
+pytest
+pytest-cov
 pyflakes
 Pygments
 pyroma
diff --git a/setup.cfg b/setup.cfg
index 0c9e0fc1447..4a133839622 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -1,2 +1,6 @@
+[aliases]
+test=pytest
 [metadata]
 license_file = LICENSE
+[tool:pytest]
+addopts = -vx --cov PIL --cov-report term Tests
diff --git a/setup.py b/setup.py
index 58a282ac300..1902d937307 100755
--- a/setup.py
+++ b/setup.py
@@ -59,6 +59,7 @@ class RequiredDependencyException(Exception): pass
 PLATFORM_MINGW = 'mingw' in ccompiler.get_default_compiler()
 PLATFORM_PYPY = hasattr(sys, 'pypy_version_info')
 
+
 def _dbg(s, tp=None):
     if DEBUG:
         if tp:
@@ -748,6 +749,9 @@ def debug_build():
     return hasattr(sys, 'gettotalrefcount')
 
 
+needs_pytest = {'pytest', 'test', 'ptr'}.intersection(sys.argv)
+pytest_runner = ['pytest-runner'] if needs_pytest else []
+
 try:
     setup(name=NAME,
           version=PILLOW_VERSION,
@@ -779,7 +783,8 @@ def debug_build():
           include_package_data=True,
           packages=find_packages(),
           scripts=glob.glob("Scripts/*.py"),
-          test_suite='nose.collector',
+          setup_requires=pytest_runner,
+          tests_require=['pytest'],
           keywords=["Imaging", ],
           license='Standard PIL License',
           zip_safe=not (debug_build() or PLATFORM_MINGW), )
diff --git a/test-installed.py b/test-installed.py
deleted file mode 100755
index c5aff1360c4..00000000000
--- a/test-installed.py
+++ /dev/null
@@ -1,35 +0,0 @@
-#!/usr/bin/env python
-import nose
-import os
-import sys
-import glob
-
-# monkey with the path, removing the local directory but adding the Tests/
-# directory for helper.py and the other local imports there.
-
-del(sys.path[0])
-sys.path.insert(0, os.path.abspath('./Tests'))
-
-# if there's no test selected (mostly) choose a working default.
-# Something is required, because if we import the tests from the local
-# directory, once again, we've got the non-installed PIL in the way
-for arg in sys.argv[1:]:
-    if '.py' in arg:
-        break
-else:
-    sys.argv.extend(glob.glob('Tests/test*.py'))
-
-# Make sure that nose doesn't muck with our paths.
-if ('--no-path-adjustment' not in sys.argv) and ('-P' not in sys.argv):
-    sys.argv.insert(1, '--no-path-adjustment')
-
-if 'NOSE_PROCESSES' not in os.environ:
-    for arg in sys.argv:
-        if '--processes' in arg:
-            break
-    else:  # for
-        sys.argv.insert(1, '--processes=-1')  # -1 == number of cores
-        sys.argv.insert(1, '--process-timeout=30')
-
-if __name__ == '__main__':
-    nose.main()
diff --git a/winbuild/appveyor_install_msys2_deps.sh b/winbuild/appveyor_install_msys2_deps.sh
index 52b81443324..b13dc9e98b0 100644
--- a/winbuild/appveyor_install_msys2_deps.sh
+++ b/winbuild/appveyor_install_msys2_deps.sh
@@ -7,5 +7,5 @@ pacman -S --noconfirm mingw32/mingw-w64-i686-python3 \
 	   mingw32/mingw-w64-i686-python2-setuptools \
 	   mingw-w64-i686-libjpeg-turbo
 
-/mingw32/bin/pip install nose olefile
-/mingw32/bin/pip3 install nose olefile
+/mingw32/bin/pip install pytest pytest-cov olefile
+/mingw32/bin/pip3 install pytest pytest-cov olefile
diff --git a/winbuild/build.py b/winbuild/build.py
index 3d6c6e57f54..859a4027787 100755
--- a/winbuild/build.py
+++ b/winbuild/build.py
@@ -16,7 +16,7 @@ def setup_vms():
         for arch in ('', X64_EXT):
             ret.append("virtualenv -p c:/Python%s%s/python.exe --clear %s%s%s"
                        % (py, arch, VIRT_BASE, py, arch))
-            ret.append(r"%s%s%s\Scripts\pip.exe install nose" %
+            ret.append(r"%s%s%s\Scripts\pip.exe install pytest pytest-cov" %
                        (VIRT_BASE, py, arch))
     return "\n".join(ret)
 
@@ -76,7 +76,7 @@ def build_one(py_ver, compiler):
     args['executable'] = "python.exe"
     if 'EXECUTABLE' in os.environ:
         args['executable'] = "%EXECUTABLE%"
-        
+
     args['py_ver'] = py_ver
     if '34' in py_ver:
         args['tcl_ver'] = '86'