diff --git a/Lib/unittest/mock.py b/Lib/unittest/mock.py
index b06e29cf01c95b..cd5a2aeb6084d7 100644
--- a/Lib/unittest/mock.py
+++ b/Lib/unittest/mock.py
@@ -1601,6 +1601,10 @@ def _patch_object(
     When used as a class decorator `patch.object` honours `patch.TEST_PREFIX`
     for choosing which methods to wrap.
     """
+    if type(target) is str:
+        raise TypeError(
+            f"{target!r} must be the actual object to be patched, not a str"
+        )
     getter = lambda: target
     return _patch(
         getter, attribute, new, spec, create,
diff --git a/Lib/unittest/test/testmock/testpatch.py b/Lib/unittest/test/testmock/testpatch.py
index 0632d95e58fec0..e065a2c35fbeec 100644
--- a/Lib/unittest/test/testmock/testpatch.py
+++ b/Lib/unittest/test/testmock/testpatch.py
@@ -105,6 +105,10 @@ def test():
         self.assertEqual(Something.attribute, sentinel.Original,
                          "patch not restored")
 
+    def test_patchobject_with_string_as_target(self):
+        msg = "'Something' must be the actual object to be patched, not a str"
+        with self.assertRaisesRegex(TypeError, msg):
+            patch.object('Something', 'do_something')
 
     def test_patchobject_with_none(self):
         class Something(object):
diff --git a/Misc/NEWS.d/next/Tests/2019-11-04-02-54-16.bpo-38669.pazXZ8.rst b/Misc/NEWS.d/next/Tests/2019-11-04-02-54-16.bpo-38669.pazXZ8.rst
new file mode 100644
index 00000000000000..5060ecf2dc5a46
--- /dev/null
+++ b/Misc/NEWS.d/next/Tests/2019-11-04-02-54-16.bpo-38669.pazXZ8.rst
@@ -0,0 +1 @@
+Raise :exc:`TypeError` when passing target as a string with :meth:`unittest.mock.patch.object`.
\ No newline at end of file