diff --git a/Lib/test/test_uuid.py b/Lib/test/test_uuid.py
index 33045a78721aac..88a9d693ed6c6e 100755
--- a/Lib/test/test_uuid.py
+++ b/Lib/test/test_uuid.py
@@ -277,9 +277,17 @@ def test_exceptions(self):
         # Badly formed hex strings.
         badvalue(lambda: self.uuid.UUID(''))
         badvalue(lambda: self.uuid.UUID('abc'))
+        badvalue(lambda: self.uuid.UUID('123_4567812345678123456781234567'))
+        badvalue(lambda: self.uuid.UUID('123_4567812345678123456781_23456'))
         badvalue(lambda: self.uuid.UUID('1234567812345678123456781234567'))
         badvalue(lambda: self.uuid.UUID('123456781234567812345678123456789'))
         badvalue(lambda: self.uuid.UUID('123456781234567812345678z2345678'))
+        badvalue(lambda: self.uuid.UUID('0x123456781234567812345678z23456'))
+        badvalue(lambda: self.uuid.UUID('0X123456781234567812345678z23456'))
+        badvalue(lambda: self.uuid.UUID('+123456781234567812345678z234567'))
+        badvalue(lambda: self.uuid.UUID(' 123456781234567812345678z23456 '))
+        badvalue(lambda: self.uuid.UUID('  123456781234567812345678z2345  '))
+        badvalue(lambda: self.uuid.UUID('\uff10123456781234567812345678z234567'))
 
         # Badly formed bytes.
         badvalue(lambda: self.uuid.UUID(bytes='abc'))
diff --git a/Lib/uuid.py b/Lib/uuid.py
index c0150a59d7cb9a..b5641112d65a56 100644
--- a/Lib/uuid.py
+++ b/Lib/uuid.py
@@ -83,6 +83,7 @@
     _MAC_DELIM = b'.'
     _MAC_OMITS_LEADING_ZEROES = True
 
+_HEX_TT = str.maketrans('', '', 'abcdefABCDEF0123456789')
 RESERVED_NCS, RFC_4122, RESERVED_MICROSOFT, RESERVED_FUTURE = [
     'reserved for NCS compatibility', 'specified in RFC 4122',
     'reserved for Microsoft compatibility', 'reserved for future definition']
@@ -215,7 +216,8 @@ def __init__(self, hex=None, bytes=None, bytes_le=None, fields=None,
         elif hex is not None:
             hex = hex.replace('urn:', '').replace('uuid:', '')
             hex = hex.strip('{}').replace('-', '')
-            if len(hex) != 32:
+            # ensure that only 32 hex characters pass through
+            if len(hex) != 32 or hex.translate(_HEX_TT):
                 raise ValueError('badly formed hexadecimal UUID string')
             int = int_(hex, 16)
         elif bytes_le is not None:
diff --git a/Misc/NEWS.d/next/Library/2024-10-18-09-45-34.gh-issue-125651.M0wSAS.rst b/Misc/NEWS.d/next/Library/2024-10-18-09-45-34.gh-issue-125651.M0wSAS.rst
new file mode 100644
index 00000000000000..00c79d2dd87366
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2024-10-18-09-45-34.gh-issue-125651.M0wSAS.rst
@@ -0,0 +1 @@
+Fix HEX parsing of :class:`uuid.UUID`.