diff --git a/Lib/importlib/_bootstrap_external.py b/Lib/importlib/_bootstrap_external.py
index c5e641773e6c5e..ad9a1a391a4b40 100644
--- a/Lib/importlib/_bootstrap_external.py
+++ b/Lib/importlib/_bootstrap_external.py
@@ -1762,7 +1762,13 @@ def create_module(self, spec):
         )
 
         # Ensure that the __file__ points at the .fwork location
-        module.__file__ = path
+        try:
+            module.__file__ = path
+        except AttributeError:
+            # Not important enough to report.
+            # (The error is also ignored in _bootstrap._init_module_attrs or
+            # import_run_extension in import.c)
+            pass
 
         return module
 
diff --git a/Misc/NEWS.d/next/Library/2025-10-26-16-24-12.gh-issue-140633.ioayC1.rst b/Misc/NEWS.d/next/Library/2025-10-26-16-24-12.gh-issue-140633.ioayC1.rst
new file mode 100644
index 00000000000000..9675a5d427a0d9
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2025-10-26-16-24-12.gh-issue-140633.ioayC1.rst
@@ -0,0 +1,2 @@
+Ignore :exc:`AttributeError` when setting a module's ``__file__`` attribute
+when loading an extension module packaged as Apple Framework.