diff --git a/Misc/NEWS.d/next/Build/2025-10-25-08-07-06.gh-issue-140513.6OhLTs.rst b/Misc/NEWS.d/next/Build/2025-10-25-08-07-06.gh-issue-140513.6OhLTs.rst
new file mode 100644
index 00000000000000..1035ebf8d781cf
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2025-10-25-08-07-06.gh-issue-140513.6OhLTs.rst
@@ -0,0 +1,2 @@
+Generate a clear compilation error when ``_Py_TAIL_CALL_INTERP`` is enabled but
+either ``preserve_none`` or ``musttail`` is not supported.
diff --git a/Python/ceval_macros.h b/Python/ceval_macros.h
index 187ec8fdd26584..37c4b00f86df25 100644
--- a/Python/ceval_macros.h
+++ b/Python/ceval_macros.h
@@ -79,6 +79,14 @@
 #endif
 
 #if Py_TAIL_CALL_INTERP
+#   if defined(__clang__) || defined(__GNUC__)
+#       if !_Py__has_attribute(preserve_none) || !_Py__has_attribute(musttail)
+#           error "This compiler does not have support for efficient tail calling."
+#       endif
+#   elif defined(_MSC_VER)
+#       error "Tail calling not supported for MSVC."
+#   endif
+
     // Note: [[clang::musttail]] works for GCC 15, but not __attribute__((musttail)) at the moment.
 #   define Py_MUSTTAIL [[clang::musttail]]
 #   define Py_PRESERVE_NONE_CC __attribute__((preserve_none))