diff --git a/Misc/NEWS.d/next/Build/2025-11-20-17-01-05.gh-issue-141784.LkYI2n.rst b/Misc/NEWS.d/next/Build/2025-11-20-17-01-05.gh-issue-141784.LkYI2n.rst
new file mode 100644
index 00000000000000..f20d84094162ac
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2025-11-20-17-01-05.gh-issue-141784.LkYI2n.rst
@@ -0,0 +1,4 @@
+Fix ``_remote_debugging_module.c`` compilation on 32-bit Linux. Include
+Python.h before system headers to make sure that
+``_remote_debugging_module.c`` uses the same types (ABI) than Python. Patch
+by Victor Stinner.
diff --git a/Modules/_remote_debugging_module.c b/Modules/_remote_debugging_module.c
index 6544e3a0ce6876..928bc9ff47a378 100644
--- a/Modules/_remote_debugging_module.c
+++ b/Modules/_remote_debugging_module.c
@@ -11,15 +11,6 @@
  * HEADERS AND INCLUDES
  * ============================================================================ */
 
-#include <assert.h>
-#include <errno.h>
-#include <fcntl.h>
-#include <stddef.h>
-#include <stdint.h>
-#include <stdio.h>
-#include <stdlib.h>
-#include <string.h>
-
 #ifndef Py_BUILD_CORE_BUILTIN
 #    define Py_BUILD_CORE_MODULE 1
 #endif
@@ -32,6 +23,18 @@
 #include <internal/pycore_stackref.h>       // Py_TAG_BITS
 #include "../Python/remote_debug.h"
 
+// gh-141784: Python.h header must be included first, before system headers.
+// Otherwise, some types such as ino_t can be defined differently, causing ABI
+// issues.
+#include <assert.h>
+#include <errno.h>
+#include <fcntl.h>
+#include <stddef.h>
+#include <stdint.h>
+#include <stdio.h>
+#include <stdlib.h>
+#include <string.h>
+
 #ifndef HAVE_PROCESS_VM_READV
 #    define HAVE_PROCESS_VM_READV 0
 #endif