diff --git a/Lib/re/_compiler.py b/Lib/re/_compiler.py
index 20dd561d1c1520..c2ca8e25abe34d 100644
--- a/Lib/re/_compiler.py
+++ b/Lib/re/_compiler.py
@@ -375,7 +375,7 @@ def _optimize_charset(charset, iscased=None, fixup=None, fixes=None):
     # less significant byte is a bit index in the chunk (just like the
     # CHARSET matching).
 
-    charmap = bytes(charmap) # should be hashable
+    charmap = charmap.take_bytes() # should be hashable
     comps = {}
     mapping = bytearray(256)
     block = 0
diff --git a/Misc/NEWS.d/next/Library/2025-11-26-14-20-10.gh-issue-141968.W139Pv.rst b/Misc/NEWS.d/next/Library/2025-11-26-14-20-10.gh-issue-141968.W139Pv.rst
new file mode 100644
index 00000000000000..c5375707814ff5
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2025-11-26-14-20-10.gh-issue-141968.W139Pv.rst
@@ -0,0 +1,2 @@
+Remove data copy from :mod:`re` compilation of regexes with large charsets
+by using :meth:`bytearray.take_bytes`.