diff --git a/Doc/library/subprocess.rst b/Doc/library/subprocess.rst
index 43da804b62beb1..95014e2b66d92f 100644
--- a/Doc/library/subprocess.rst
+++ b/Doc/library/subprocess.rst
@@ -264,6 +264,182 @@ underlying :class:`Popen` interface can be used directly.
         *stdout* and *stderr* attributes added
 
 
+.. function:: run_pipeline(*commands, stdin=None, input=None, \
+                           stdout=None, stderr=None, capture_output=False, \
+                           timeout=None, check=False, encoding=None, \
+                           errors=None, text=None, env=None, \
+                           **other_popen_kwargs)
+
+   Run a pipeline of commands connected via pipes, similar to shell pipelines.
+   Wait for all commands to complete, then return a :class:`PipelineResult`
+   instance.
+
+   Each positional argument should be a command (a list of strings, or a string
+   if ``shell=True``) to execute. The standard output of each command is
+   connected to the standard input of the next command in the pipeline.
+
+   This function requires at least two commands. For a single command, use
+   :func:`run` instead.
+
+   If *capture_output* is true, the standard output of the final command and
+   the standard error of all commands will be captured. All processes in the
+   pipeline share a single stderr pipe, so their error output will be
+   interleaved. The *stdout* and *stderr* arguments may not be supplied at
+   the same time as *capture_output*.
+
+   A *timeout* may be specified in seconds. If the timeout expires, all
+   child processes will be killed and waited for, and then a
+   :exc:`TimeoutExpired` exception will be raised.
+
+   The *input* argument is passed to the first command's stdin. If used, it
+   must be a byte sequence, or a string if *encoding* or *errors* is specified
+   or *text* is true.
+
+   If *check* is true, and any process in the pipeline exits with a non-zero
+   exit code, a :exc:`PipelineError` exception will be raised. This behavior
+   is similar to the shell's ``pipefail`` option.
+
+   If *encoding* or *errors* are specified, or *text* is true, file objects
+   are opened in text mode using the specified encoding and errors.
+
+   .. note::
+
+      When using ``text=True`` with ``capture_output=True`` or ``stderr=PIPE``,
+      be aware that stderr output from multiple processes may be interleaved
+      in ways that produce incomplete multi-byte character sequences. For
+      reliable text decoding of stderr, consider capturing in binary mode
+      and decoding manually with appropriate error handling, or use
+      ``errors='replace'`` or ``errors='backslashreplace'``.
+
+   If *stdin* is specified, it is connected to the first command's standard
+   input. If *stdout* is specified, it is connected to the last command's
+   standard output. When *stdout* is :data:`PIPE`, the output is available
+   in the returned :class:`PipelineResult`'s :attr:`~PipelineResult.stdout`
+   attribute. Other keyword arguments are passed to each :class:`Popen` call.
+
+   Examples::
+
+      >>> import subprocess
+      >>> # Equivalent to: echo "hello world" | tr a-z A-Z
+      >>> result = subprocess.run_pipeline(
+      ...     ['echo', 'hello world'],
+      ...     ['tr', 'a-z', 'A-Z'],
+      ...     capture_output=True, text=True
+      ... )
+      >>> result.stdout
+      'HELLO WORLD\n'
+      >>> result.returncodes
+      [0, 0]
+
+      >>> # Pipeline with three commands
+      >>> result = subprocess.run_pipeline(
+      ...     ['echo', 'one\ntwo\nthree'],
+      ...     ['sort'],
+      ...     ['head', '-n', '2'],
+      ...     capture_output=True, text=True
+      ... )
+      >>> result.stdout
+      'one\nthree\n'
+
+      >>> # Using input parameter
+      >>> result = subprocess.run_pipeline(
+      ...     ['cat'],
+      ...     ['wc', '-l'],
+      ...     input='line1\nline2\nline3\n',
+      ...     capture_output=True, text=True
+      ... )
+      >>> result.stdout.strip()
+      '3'
+
+      >>> # Error handling with check=True
+      >>> subprocess.run_pipeline(
+      ...     ['echo', 'hello'],
+      ...     ['false'],  # exits with status 1
+      ...     check=True
+      ... )
+      Traceback (most recent call last):
+        ...
+      subprocess.PipelineError: Pipeline failed: command 1 ['false'] returned 1
+
+   .. versionadded:: next
+
+
+.. class:: PipelineResult
+
+   The return value from :func:`run_pipeline`, representing a pipeline of
+   processes that have finished.
+
+   .. attribute:: commands
+
+      The list of commands used to launch the pipeline. Each command is a list
+      of strings (or a string if ``shell=True`` was used).
+
+   .. attribute:: returncodes
+
+      List of exit status codes for each command in the pipeline. Typically,
+      an exit status of 0 indicates that the command ran successfully.
+
+      A negative value ``-N`` indicates that the command was terminated by
+      signal ``N`` (POSIX only).
+
+   .. attribute:: returncode
+
+      Exit status of the final command in the pipeline. This is a convenience
+      property equivalent to ``returncodes[-1]``.
+
+   .. attribute:: stdout
+
+      Captured stdout from the final command in the pipeline. A bytes sequence,
+      or a string if :func:`run_pipeline` was called with an encoding, errors,
+      or ``text=True``. ``None`` if stdout was not captured.
+
+   .. attribute:: stderr
+
+      Captured stderr from all commands in the pipeline, combined. A bytes
+      sequence, or a string if :func:`run_pipeline` was called with an
+      encoding, errors, or ``text=True``. ``None`` if stderr was not captured.
+
+   .. method:: check_returncodes()
+
+      If any command's :attr:`returncode` is non-zero, raise a
+      :exc:`PipelineError`.
+
+   .. versionadded:: next
+
+
+.. exception:: PipelineError
+
+   Subclass of :exc:`SubprocessError`, raised when a pipeline run by
+   :func:`run_pipeline` (with ``check=True``) contains one or more commands
+   that returned a non-zero exit status. This is similar to the shell's
+   ``pipefail`` behavior.
+
+   .. attribute:: commands
+
+      List of commands that were used in the pipeline.
+
+   .. attribute:: returncodes
+
+      List of exit status codes for each command in the pipeline.
+
+   .. attribute:: stdout
+
+      Output of the final command if it was captured. Otherwise, ``None``.
+
+   .. attribute:: stderr
+
+      Combined stderr output of all commands if it was captured.
+      Otherwise, ``None``.
+
+   .. attribute:: failed
+
+      List of ``(index, command, returncode)`` tuples for each command
+      that returned a non-zero exit status. The *index* is the position
+      of the command in the pipeline (0-based).
+
+   .. versionadded:: next
+
+
 .. _frequently-used-arguments:
 
 Frequently Used Arguments
diff --git a/Lib/subprocess.py b/Lib/subprocess.py
index 4d5ab6fbff0a46..702918b8c38f84 100644
--- a/Lib/subprocess.py
+++ b/Lib/subprocess.py
@@ -62,7 +62,8 @@
 
 __all__ = ["Popen", "PIPE", "STDOUT", "call", "check_call", "getstatusoutput",
            "getoutput", "check_output", "run", "CalledProcessError", "DEVNULL",
-           "SubprocessError", "TimeoutExpired", "CompletedProcess"]
+           "SubprocessError", "TimeoutExpired", "CompletedProcess",
+           "run_pipeline", "PipelineResult", "PipelineError"]
            # NOTE: We intentionally exclude list2cmdline as it is
            # considered an internal implementation detail.  issue10838.
 
@@ -194,6 +195,36 @@ def stdout(self, value):
         self.output = value
 
 
+class PipelineError(SubprocessError):
+    """Raised when run_pipeline() is called with check=True and one or more
+    commands in the pipeline return a non-zero exit status.
+
+    Attributes:
+        commands: List of commands in the pipeline (each a list of strings).
+        returncodes: List of return codes corresponding to each command.
+        stdout: Standard output from the final command (if captured).
+        stderr: Standard error output (if captured).
+        failed: List of (index, command, returncode) tuples for failed commands.
+    """
+    def __init__(self, commands, returncodes, stdout=None, stderr=None):
+        self.commands = commands
+        self.returncodes = returncodes
+        self.stdout = stdout
+        self.stderr = stderr
+        self.failed = [
+            (i, cmd, rc)
+            for i, (cmd, rc) in enumerate(zip(commands, returncodes))
+            if rc != 0
+        ]
+
+    def __str__(self):
+        failed_info = ", ".join(
+            f"command {i} {cmd!r} returned {rc}"
+            for i, cmd, rc in self.failed
+        )
+        return f"Pipeline failed: {failed_info}"
+
+
 if _mswindows:
     class STARTUPINFO:
         def __init__(self, *, dwFlags=0, hStdInput=None, hStdOutput=None,
@@ -289,6 +320,295 @@ def _cleanup():
 DEVNULL = -3
 
 
+# Helper function for multiplexed I/O
+def _remaining_time_helper(endtime):
+    """Calculate remaining time until deadline."""
+    if endtime is None:
+        return None
+    return endtime - _time()
+
+
+def _flush_stdin(stdin):
+    """Flush stdin, ignoring BrokenPipeError and closed file ValueError."""
+    try:
+        stdin.flush()
+    except BrokenPipeError:
+        pass
+    except ValueError:
+        # Ignore ValueError: I/O operation on closed file.
+        if not stdin.closed:
+            raise
+
+
+def _make_input_view(input_data):
+    """Convert input data to a byte memoryview for writing.
+
+    Handles the case where input_data is already a memoryview with
+    non-byte elements (e.g., int32 array) by casting to a byte view.
+    This ensures len(view) returns the byte count, not element count.
+    """
+    if not input_data:
+        return None
+    if isinstance(input_data, memoryview):
+        return input_data.cast("b")  # ensure byte view for correct len()
+    return memoryview(input_data)
+
+
+def _translate_newlines(data, encoding, errors):
+    """Decode bytes to str and translate newlines to \n."""
+    data = data.decode(encoding, errors)
+    return data.replace("\r\n", "\n").replace("\r", "\n")
+
+
+def _communicate_io_posix(selector, stdin, input_view, input_offset,
+                          output_buffers, endtime):
+    """
+    Low-level POSIX I/O multiplexing loop.
+
+    This is the common core used by both _communicate_streams() and
+    Popen._communicate(). It handles the select loop for reading/writing
+    but does not manage stream lifecycle or raise timeout exceptions.
+
+    Args:
+        selector: A _PopenSelector with streams already registered
+        stdin: Writable file object for input, or None
+        input_view: memoryview of input bytes, or None
+        input_offset: Starting offset into input_view (for resume support)
+        output_buffers: Dict {file_object: list} to append read chunks to
+        endtime: Deadline timestamp, or None for no timeout
+
+    Returns:
+        (new_input_offset, completed)
+        - new_input_offset: How many bytes of input were written
+        - completed: True if all I/O finished, False if timed out
+
+    Note:
+        - Does NOT close any streams (caller decides)
+        - Does NOT raise TimeoutExpired (caller handles)
+        - Appends to output_buffers lists in place
+    """
+    stdin_fd = stdin.fileno() if stdin else None
+
+    while selector.get_map():
+        remaining = _remaining_time_helper(endtime)
+        if remaining is not None and remaining < 0:
+            return (input_offset, False)  # Timed out
+
+        ready = selector.select(remaining)
+
+        # Check timeout after select (may have woken spuriously)
+        if endtime is not None and _time() > endtime:
+            return (input_offset, False)  # Timed out
+
+        for key, events in ready:
+            if key.fd == stdin_fd:
+                # Write chunk to stdin
+                chunk = input_view[input_offset:input_offset + _PIPE_BUF]
+                try:
+                    input_offset += os.write(key.fd, chunk)
+                except BrokenPipeError:
+                    selector.unregister(key.fd)
+                    try:
+                        stdin.close()
+                    except BrokenPipeError:
+                        pass
+                else:
+                    if input_offset >= len(input_view):
+                        selector.unregister(key.fd)
+                        try:
+                            stdin.close()
+                        except BrokenPipeError:
+                            pass
+            elif key.fileobj in output_buffers:
+                # Read chunk from output stream
+                data = os.read(key.fd, 32768)
+                if not data:
+                    selector.unregister(key.fileobj)
+                else:
+                    output_buffers[key.fileobj].append(data)
+
+    return (input_offset, True)  # Completed
+
+
+def _communicate_streams(stdin=None, input_data=None, read_streams=None,
+                         timeout=None, cmd_for_timeout=None):
+    """
+    Multiplex I/O: write input_data to stdin, read from read_streams.
+
+    All streams must be file objects (not raw file descriptors).
+    All I/O is done in binary mode; caller handles text encoding.
+
+    Args:
+        stdin: Writable binary file object for input, or None
+        input_data: Bytes to write to stdin, or None
+        read_streams: List of readable binary file objects to read from
+        timeout: Timeout in seconds, or None for no timeout
+        cmd_for_timeout: Value to use for TimeoutExpired.cmd
+
+    Returns:
+        Dict mapping each file object in read_streams to its bytes data.
+        All file objects in read_streams will be closed.
+
+    Raises:
+        TimeoutExpired: If timeout expires (with partial data)
+    """
+    if timeout is not None:
+        endtime = _time() + timeout
+    else:
+        endtime = None
+
+    read_streams = read_streams or []
+
+    if _mswindows:
+        return _communicate_streams_windows(
+            stdin, input_data, read_streams, endtime, timeout, cmd_for_timeout)
+    else:
+        return _communicate_streams_posix(
+            stdin, input_data, read_streams, endtime, timeout, cmd_for_timeout)
+
+
+if _mswindows:
+    def _reader_thread_func(fh, buffer):
+        """Thread function to read from a file handle into a buffer list."""
+        try:
+            buffer.append(fh.read())
+        except OSError:
+            buffer.append(b'')
+
+    def _writer_thread_func(fh, data, result):
+        """Thread function to write data to a file handle and close it."""
+        try:
+            if data:
+                fh.write(data)
+        except BrokenPipeError:
+            pass
+        except OSError as exc:
+            if exc.errno != errno.EINVAL:
+                result.append(exc)
+        try:
+            fh.close()
+        except BrokenPipeError:
+            pass
+        except OSError as exc:
+            if exc.errno != errno.EINVAL and not result:
+                result.append(exc)
+
+    def _communicate_streams_windows(stdin, input_data, read_streams,
+                                     endtime, orig_timeout, cmd_for_timeout):
+        """Windows implementation using threads."""
+        threads = []
+        buffers = {}
+        writer_thread = None
+        writer_result = []
+
+        # Start writer thread to send input to stdin
+        if stdin and input_data:
+            writer_thread = threading.Thread(
+                target=_writer_thread_func,
+                args=(stdin, input_data, writer_result))
+            writer_thread.daemon = True
+            writer_thread.start()
+        elif stdin:
+            # No input data, just close stdin
+            try:
+                stdin.close()
+            except BrokenPipeError:
+                pass
+            except OSError as exc:
+                if exc.errno != errno.EINVAL:
+                    raise
+
+        # Start reader threads for each stream
+        for stream in read_streams:
+            buf = []
+            buffers[stream] = buf
+            t = threading.Thread(target=_reader_thread_func, args=(stream, buf))
+            t.daemon = True
+            t.start()
+            threads.append((stream, t))
+
+        # Join writer thread with timeout first
+        if writer_thread is not None:
+            remaining = _remaining_time_helper(endtime)
+            if remaining is not None and remaining < 0:
+                remaining = 0
+            writer_thread.join(remaining)
+            if writer_thread.is_alive():
+                # Timed out during write - collect partial results
+                results = {s: (b[0] if b else b'') for s, b in buffers.items()}
+                raise TimeoutExpired(
+                    cmd_for_timeout, orig_timeout,
+                    output=results.get(read_streams[0]) if read_streams else None)
+            # Check for write errors
+            if writer_result:
+                raise writer_result[0]
+
+        # Join reader threads with timeout
+        for stream, t in threads:
+            remaining = _remaining_time_helper(endtime)
+            if remaining is not None and remaining < 0:
+                remaining = 0
+            t.join(remaining)
+            if t.is_alive():
+                # Collect partial results
+                results = {s: (b[0] if b else b'') for s, b in buffers.items()}
+                raise TimeoutExpired(
+                    cmd_for_timeout, orig_timeout,
+                    output=results.get(read_streams[0]) if read_streams else None)
+
+        # Collect results
+        return {stream: (buf[0] if buf else b'') for stream, buf in buffers.items()}
+
+else:
+    def _communicate_streams_posix(stdin, input_data, read_streams,
+                                   endtime, orig_timeout, cmd_for_timeout):
+        """POSIX implementation using selectors."""
+        # Build output buffers for each stream
+        output_buffers = {stream: [] for stream in read_streams}
+
+        # Prepare stdin
+        if stdin:
+            _flush_stdin(stdin)
+            if not input_data:
+                try:
+                    stdin.close()
+                except BrokenPipeError:
+                    pass
+                stdin = None  # Don't register with selector
+
+        # Prepare input data
+        input_view = _make_input_view(input_data)
+
+        with _PopenSelector() as selector:
+            if stdin and input_data:
+                selector.register(stdin, selectors.EVENT_WRITE)
+            for stream in read_streams:
+                selector.register(stream, selectors.EVENT_READ)
+
+            # Run the common I/O loop
+            _, completed = _communicate_io_posix(
+                selector, stdin, input_view, 0, output_buffers, endtime)
+
+        if not completed:
+            # Timed out - collect partial results
+            results = {stream: b''.join(chunks)
+                       for stream, chunks in output_buffers.items()}
+            raise TimeoutExpired(
+                cmd_for_timeout, orig_timeout,
+                output=results.get(read_streams[0]) if read_streams else None)
+
+        # Build results and close all file objects
+        results = {}
+        for stream, chunks in output_buffers.items():
+            results[stream] = b''.join(chunks)
+            try:
+                stream.close()
+            except OSError:
+                pass
+
+        return results
+
+
 # XXX This function is only used by multiprocessing and the test suite,
 # but it's here so that it can be imported when Python is compiled without
 # threads.
@@ -508,6 +828,47 @@ def check_returncode(self):
                                      self.stderr)
 
 
+class PipelineResult:
+    """A pipeline of processes that have finished running.
+
+    This is returned by run_pipeline().
+
+    Attributes:
+        commands: List of commands in the pipeline (each command is a list).
+        returncodes: List of return codes for each command in the pipeline.
+        returncode: The return code of the final command (for convenience).
+        stdout: The standard output of the final command (None if not captured).
+        stderr: The standard error output (None if not captured).
+    """
+    def __init__(self, commands, returncodes, stdout=None, stderr=None):
+        self.commands = list(commands)
+        self.returncodes = list(returncodes)
+        self.stdout = stdout
+        self.stderr = stderr
+
+    @property
+    def returncode(self):
+        """Return the exit code of the final command in the pipeline."""
+        return self.returncodes[-1] if self.returncodes else None
+
+    def __repr__(self):
+        args = [f'commands={self.commands!r}',
+                f'returncodes={self.returncodes!r}']
+        if self.stdout is not None:
+            args.append(f'stdout={self.stdout!r}')
+        if self.stderr is not None:
+            args.append(f'stderr={self.stderr!r}')
+        return f"{type(self).__name__}({', '.join(args)})"
+
+    __class_getitem__ = classmethod(types.GenericAlias)
+
+    def check_returncodes(self):
+        """Raise PipelineError if any command's exit code is non-zero."""
+        if any(rc != 0 for rc in self.returncodes):
+            raise PipelineError(self.commands, self.returncodes,
+                                self.stdout, self.stderr)
+
+
 def run(*popenargs,
         input=None, capture_output=False, timeout=None, check=False, **kwargs):
     """Run command with arguments and return a CompletedProcess instance.
@@ -578,6 +939,235 @@ def run(*popenargs,
     return CompletedProcess(process.args, retcode, stdout, stderr)
 
 
+def run_pipeline(*commands, input=None, capture_output=False, timeout=None,
+                 check=False, **kwargs):
+    """Run a pipeline of commands connected via pipes.
+
+    Each positional argument should be a command (list of strings or a string
+    if shell=True) to execute. The stdout of each command is connected to the
+    stdin of the next command in the pipeline, similar to shell pipelines.
+
+    Returns a PipelineResult instance with attributes commands, returncodes,
+    stdout, and stderr. By default, stdout and stderr are not captured, and
+    those attributes will be None. Pass capture_output=True to capture both
+    the final command's stdout and stderr from all commands.
+
+    If check is True and any command's exit code is non-zero, it raises a
+    PipelineError. This is similar to shell "pipefail" behavior.
+
+    If timeout (seconds) is given and the pipeline takes too long, a
+    TimeoutExpired exception will be raised and all processes will be killed.
+
+    The optional "input" argument allows passing bytes or a string to the
+    first command's stdin. If you use this argument, you may not also specify
+    stdin in kwargs.
+
+    By default, all communication is in bytes. Use text=True, encoding, or
+    errors to enable text mode, which affects the input argument and stdout/
+    stderr outputs.
+
+    .. note::
+       When using text=True with capture_output=True or stderr=PIPE, be aware
+       that stderr output from multiple processes may be interleaved in ways
+       that produce invalid character sequences when decoded. For reliable
+       text decoding, avoid text=True when capturing stderr from pipelines,
+       or handle decoding errors appropriately.
+
+    Other keyword arguments are passed to each Popen call, except for stdin,
+    stdout which are managed by the pipeline.
+
+    Example:
+        # Equivalent to: cat file.txt | grep pattern | wc -l
+        result = run_pipeline(
+            ['cat', 'file.txt'],
+            ['grep', 'pattern'],
+            ['wc', '-l'],
+            capture_output=True, text=True
+        )
+        print(result.stdout)  # "42\\n"
+        print(result.returncodes)  # [0, 0, 0]
+    """
+    if len(commands) < 2:
+        raise ValueError('run_pipeline requires at least 2 commands')
+
+    # Validate no conflicting arguments
+    if input is not None:
+        if kwargs.get('stdin') is not None:
+            raise ValueError('stdin and input arguments may not both be used.')
+
+    if capture_output:
+        if kwargs.get('stdout') is not None or kwargs.get('stderr') is not None:
+            raise ValueError('stdout and stderr arguments may not be used '
+                             'with capture_output.')
+
+    # Determine stderr handling - all processes share the same stderr pipe
+    # When capturing, we create one pipe and all processes write to it
+    stderr_arg = kwargs.pop('stderr', None)
+    capture_stderr = capture_output or stderr_arg == PIPE
+
+    # stdin is for the first process, stdout is for the last process
+    stdin_arg = kwargs.pop('stdin', None)
+    stdout_arg = kwargs.pop('stdout', None)
+
+    processes = []
+    stderr_reader = None    # File object for reading shared stderr (for parent)
+    stderr_write_fd = None  # Write end of shared stderr pipe (for children)
+
+    try:
+        # Create a single stderr pipe that all processes will share
+        if capture_stderr:
+            stderr_read_fd, stderr_write_fd = os.pipe()
+            stderr_reader = os.fdopen(stderr_read_fd, 'rb')
+
+        for i, cmd in enumerate(commands):
+            is_first = (i == 0)
+            is_last = (i == len(commands) - 1)
+
+            # Determine stdin for this process
+            if is_first:
+                if input is not None:
+                    proc_stdin = PIPE
+                else:
+                    proc_stdin = stdin_arg  # Could be None, PIPE, fd, or file
+            else:
+                proc_stdin = processes[-1].stdout
+
+            # Determine stdout for this process
+            if is_last:
+                if capture_output:
+                    proc_stdout = PIPE
+                else:
+                    proc_stdout = stdout_arg  # Could be None, PIPE, fd, or file
+            else:
+                proc_stdout = PIPE
+
+            # All processes share the same stderr pipe (write end)
+            if capture_stderr:
+                proc_stderr = stderr_write_fd
+            else:
+                proc_stderr = stderr_arg
+
+            proc = Popen(cmd, stdin=proc_stdin, stdout=proc_stdout,
+                         stderr=proc_stderr, **kwargs)
+            processes.append(proc)
+
+            # Close the parent's copy of the previous process's stdout
+            # to allow the pipe to signal EOF when the previous process exits
+            if not is_first and processes[-2].stdout is not None:
+                processes[-2].stdout.close()
+
+        # Close the write end of stderr pipe in parent - children have it
+        if stderr_write_fd is not None:
+            os.close(stderr_write_fd)
+            stderr_write_fd = None
+
+        first_proc = processes[0]
+        last_proc = processes[-1]
+
+        # Calculate deadline for timeout (used throughout)
+        if timeout is not None:
+            endtime = _time() + timeout
+        else:
+            endtime = None
+
+        # Determine if we're in text mode (text= or universal_newlines=)
+        text_mode = (kwargs.get('text') or kwargs.get('universal_newlines')
+                     or kwargs.get('encoding') or kwargs.get('errors'))
+        encoding = kwargs.get('encoding')
+        errors_param = kwargs.get('errors', 'strict')
+        if text_mode and encoding is None:
+            encoding = locale.getencoding()
+
+        # Encode input if in text mode
+        input_data = input
+        if input_data is not None and text_mode:
+            input_data = input_data.encode(encoding, errors_param)
+
+        # Build list of streams to read from
+        read_streams = []
+        if last_proc.stdout is not None:
+            read_streams.append(last_proc.stdout)
+        if stderr_reader is not None:
+            read_streams.append(stderr_reader)
+
+        # Use multiplexed I/O to handle stdin/stdout/stderr concurrently
+        # This avoids deadlocks from pipe buffer limits
+        stdin_stream = first_proc.stdin if input is not None else None
+
+        try:
+            results = _communicate_streams(
+                stdin=stdin_stream,
+                input_data=input_data,
+                read_streams=read_streams,
+                timeout=_remaining_time_helper(endtime),
+                cmd_for_timeout=commands,
+            )
+        except TimeoutExpired:
+            # Kill all processes on timeout
+            for p in processes:
+                if p.poll() is None:
+                    p.kill()
+            for p in processes:
+                p.wait()
+            raise
+
+        # Extract results
+        stdout = results.get(last_proc.stdout)
+        stderr = results.get(stderr_reader)
+
+        # Translate newlines if in text mode (decode and convert \r\n to \n)
+        if text_mode and stdout is not None:
+            stdout = _translate_newlines(stdout, encoding, errors_param)
+        if text_mode and stderr is not None:
+            stderr = _translate_newlines(stderr, encoding, errors_param)
+
+        # Wait for all processes to complete (use remaining time from deadline)
+        returncodes = []
+        for proc in processes:
+            try:
+                remaining = _remaining_time_helper(endtime)
+                proc.wait(timeout=remaining)
+            except TimeoutExpired:
+                # Kill all processes on timeout
+                for p in processes:
+                    if p.poll() is None:
+                        p.kill()
+                for p in processes:
+                    p.wait()
+                raise TimeoutExpired(commands, timeout, stdout, stderr)
+            returncodes.append(proc.returncode)
+
+        result = PipelineResult(commands, returncodes, stdout, stderr)
+
+        if check and any(rc != 0 for rc in returncodes):
+            raise PipelineError(commands, returncodes, stdout, stderr)
+
+        return result
+
+    finally:
+        # Ensure all processes are cleaned up
+        for proc in processes:
+            if proc.poll() is None:
+                proc.kill()
+                proc.wait()
+            # Close any open file handles
+            if proc.stdin and not proc.stdin.closed:
+                proc.stdin.close()
+            if proc.stdout and not proc.stdout.closed:
+                proc.stdout.close()
+        # Close stderr pipe (reader is a file object, writer is a raw fd)
+        if stderr_reader is not None and not stderr_reader.closed:
+            try:
+                stderr_reader.close()
+            except OSError:
+                pass
+        if stderr_write_fd is not None:
+            try:
+                os.close(stderr_write_fd)
+            except OSError:
+                pass
+
+
 def list2cmdline(seq):
     """
     Translate a sequence of arguments into a command line
@@ -1094,8 +1684,7 @@ def universal_newlines(self, universal_newlines):
         self.text_mode = bool(universal_newlines)
 
     def _translate_newlines(self, data, encoding, errors):
-        data = data.decode(encoding, errors)
-        return data.replace("\r\n", "\n").replace("\r", "\n")
+        return _translate_newlines(data, encoding, errors)
 
     def __enter__(self):
         return self
@@ -2092,14 +2681,7 @@ def _communicate(self, input, endtime, orig_timeout):
             if self.stdin and not self._communication_started:
                 # Flush stdio buffer.  This might block, if the user has
                 # been writing to .stdin in an uncontrolled fashion.
-                try:
-                    self.stdin.flush()
-                except BrokenPipeError:
-                    pass  # communicate() must ignore BrokenPipeError.
-                except ValueError:
-                    # ignore ValueError: I/O operation on closed file.
-                    if not self.stdin.closed:
-                        raise
+                _flush_stdin(self.stdin)
                 if not input:
                     try:
                         self.stdin.close()
@@ -2124,11 +2706,8 @@ def _communicate(self, input, endtime, orig_timeout):
 
             self._save_input(input)
 
-            if self._input:
-                if not isinstance(self._input, memoryview):
-                    input_view = memoryview(self._input)
-                else:
-                    input_view = self._input.cast("b")  # byte input required
+            input_view = _make_input_view(self._input)
+            input_offset = self._input_offset if self._input else 0
 
             with _PopenSelector() as selector:
                 if self.stdin and not self.stdin.closed and self._input:
@@ -2138,41 +2717,32 @@ def _communicate(self, input, endtime, orig_timeout):
                 if self.stderr and not self.stderr.closed:
                     selector.register(self.stderr, selectors.EVENT_READ)
 
-                while selector.get_map():
-                    timeout = self._remaining_time(endtime)
-                    if timeout is not None and timeout < 0:
-                        self._check_timeout(endtime, orig_timeout,
-                                            stdout, stderr,
-                                            skip_check_and_raise=True)
-                        raise RuntimeError(  # Impossible :)
-                            '_check_timeout(..., skip_check_and_raise=True) '
-                            'failed to raise TimeoutExpired.')
-
-                    ready = selector.select(timeout)
-                    self._check_timeout(endtime, orig_timeout, stdout, stderr)
-
-                    # XXX Rewrite these to use non-blocking I/O on the file
-                    # objects; they are no longer using C stdio!
-
-                    for key, events in ready:
-                        if key.fileobj is self.stdin:
-                            chunk = input_view[self._input_offset :
-                                               self._input_offset + _PIPE_BUF]
-                            try:
-                                self._input_offset += os.write(key.fd, chunk)
-                            except BrokenPipeError:
-                                selector.unregister(key.fileobj)
-                                key.fileobj.close()
-                            else:
-                                if self._input_offset >= len(input_view):
-                                    selector.unregister(key.fileobj)
-                                    key.fileobj.close()
-                        elif key.fileobj in (self.stdout, self.stderr):
-                            data = os.read(key.fd, 32768)
-                            if not data:
-                                selector.unregister(key.fileobj)
-                                key.fileobj.close()
-                            self._fileobj2output[key.fileobj].append(data)
+                # Use the common I/O loop (supports resume via _input_offset)
+                stdin_to_write = (self.stdin if self.stdin and self._input
+                                  and not self.stdin.closed else None)
+                new_offset, completed = _communicate_io_posix(
+                    selector,
+                    stdin_to_write,
+                    input_view,
+                    input_offset,
+                    self._fileobj2output,
+                    endtime)
+                if self._input:
+                    self._input_offset = new_offset
+
+            if not completed:
+                self._check_timeout(endtime, orig_timeout, stdout, stderr,
+                                    skip_check_and_raise=True)
+                raise RuntimeError(  # Impossible :)
+                    '_check_timeout(..., skip_check_and_raise=True) '
+                    'failed to raise TimeoutExpired.')
+
+            # Close streams now that we're done reading
+            if self.stdout:
+                self.stdout.close()
+            if self.stderr:
+                self.stderr.close()
+
             try:
                 self.wait(timeout=self._remaining_time(endtime))
             except TimeoutExpired as exc:
diff --git a/Lib/test/test_subprocess.py b/Lib/test/test_subprocess.py
index 806a1e3fa303eb..4e43ea7bbfda90 100644
--- a/Lib/test/test_subprocess.py
+++ b/Lib/test/test_subprocess.py
@@ -1984,6 +1984,396 @@ def test_encoding_warning(self):
         self.assertStartsWith(lines[1], b"<string>:3: EncodingWarning: ")
 
 
+class PipelineTestCase(BaseTestCase):
+    """Tests for subprocess.run_pipeline()"""
+
+    def test_pipeline_basic(self):
+        """Test basic two-command pipeline"""
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c', 'print("hello world")'],
+            [sys.executable, '-c', 'import sys; print(sys.stdin.read().upper())'],
+            capture_output=True, text=True
+        )
+        self.assertEqual(result.stdout.strip(), 'HELLO WORLD')
+        self.assertEqual(result.returncodes, [0, 0])
+        self.assertEqual(result.returncode, 0)
+
+    def test_pipeline_three_commands(self):
+        """Test pipeline with three commands"""
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c', 'print("one\\ntwo\\nthree")'],
+            [sys.executable, '-c', 'import sys; print("".join(sorted(sys.stdin.readlines())))'],
+            [sys.executable, '-c', 'import sys; print(sys.stdin.read().strip().upper())'],
+            capture_output=True, text=True
+        )
+        self.assertEqual(result.stdout.strip(), 'ONE\nTHREE\nTWO')
+        self.assertEqual(result.returncodes, [0, 0, 0])
+
+    def test_pipeline_with_input(self):
+        """Test pipeline with input data"""
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c', 'import sys; print(sys.stdin.read().upper())'],
+            [sys.executable, '-c', 'import sys; print(len(sys.stdin.read().strip()))'],
+            input='hello', capture_output=True, text=True
+        )
+        self.assertEqual(result.stdout.strip(), '5')
+        self.assertEqual(result.returncodes, [0, 0])
+
+    def test_pipeline_memoryview_input(self):
+        """Test pipeline with memoryview input (byte elements)"""
+        test_data = b"Hello, memoryview pipeline!"
+        mv = memoryview(test_data)
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c',
+             'import sys; sys.stdout.buffer.write(sys.stdin.buffer.read())'],
+            [sys.executable, '-c',
+             'import sys; sys.stdout.buffer.write(sys.stdin.buffer.read().upper())'],
+            input=mv, capture_output=True
+        )
+        self.assertEqual(result.stdout, test_data.upper())
+        self.assertEqual(result.returncodes, [0, 0])
+
+    def test_pipeline_memoryview_input_nonbyte(self):
+        """Test pipeline with non-byte memoryview input (e.g., int32).
+
+        This tests the fix for gh-134453 where non-byte memoryviews
+        had incorrect length tracking on POSIX, causing data truncation.
+        """
+        import array
+        # Create an array of 32-bit integers large enough to trigger
+        # chunked writing behavior (> PIPE_BUF)
+        pipe_buf = getattr(select, 'PIPE_BUF', 512)
+        # Each 'i' element is 4 bytes, need more than pipe_buf bytes total
+        num_elements = (pipe_buf // 4) + 100
+        test_array = array.array('i', [0x41424344 for _ in range(num_elements)])
+        expected_bytes = test_array.tobytes()
+        mv = memoryview(test_array)
+
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c',
+             'import sys; sys.stdout.buffer.write(sys.stdin.buffer.read())'],
+            [sys.executable, '-c',
+             'import sys; data = sys.stdin.buffer.read(); '
+             'sys.stdout.buffer.write(data)'],
+            input=mv, capture_output=True
+        )
+        self.assertEqual(result.stdout, expected_bytes,
+                         msg=f"{len(result.stdout)=} != {len(expected_bytes)=}")
+        self.assertEqual(result.returncodes, [0, 0])
+
+    def test_pipeline_bytes_mode(self):
+        """Test pipeline in binary mode"""
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c', 'import sys; sys.stdout.buffer.write(b"hello")'],
+            [sys.executable, '-c', 'import sys; sys.stdout.buffer.write(sys.stdin.buffer.read().upper())'],
+            capture_output=True
+        )
+        self.assertEqual(result.stdout, b'HELLO')
+        self.assertEqual(result.returncodes, [0, 0])
+
+    def test_pipeline_error_check(self):
+        """Test that check=True raises PipelineError on failure"""
+        with self.assertRaises(subprocess.PipelineError) as cm:
+            subprocess.run_pipeline(
+                [sys.executable, '-c', 'print("hello")'],
+                [sys.executable, '-c', 'import sys; sys.exit(1)'],
+                capture_output=True, check=True
+            )
+        exc = cm.exception
+        self.assertEqual(len(exc.failed), 1)
+        self.assertEqual(exc.failed[0][0], 1)  # Second command failed
+        self.assertEqual(exc.returncodes, [0, 1])
+
+    def test_pipeline_first_command_fails(self):
+        """Test pipeline where first command fails"""
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c', 'import sys; sys.exit(42)'],
+            [sys.executable, '-c', 'import sys; print(sys.stdin.read())'],
+            capture_output=True
+        )
+        self.assertEqual(result.returncodes[0], 42)
+
+    def test_pipeline_requires_two_commands(self):
+        """Test that pipeline requires at least 2 commands"""
+        with self.assertRaises(ValueError) as cm:
+            subprocess.run_pipeline(
+                [sys.executable, '-c', 'print("hello")'],
+                capture_output=True
+            )
+        self.assertIn('at least 2 commands', str(cm.exception))
+
+    def test_pipeline_stdin_and_input_conflict(self):
+        """Test that stdin and input cannot both be specified"""
+        with self.assertRaises(ValueError) as cm:
+            subprocess.run_pipeline(
+                [sys.executable, '-c', 'pass'],
+                [sys.executable, '-c', 'pass'],
+                input='data', stdin=subprocess.PIPE
+            )
+        self.assertIn('stdin', str(cm.exception))
+        self.assertIn('input', str(cm.exception))
+
+    def test_pipeline_capture_output_conflict(self):
+        """Test that capture_output conflicts with stdout/stderr"""
+        with self.assertRaises(ValueError) as cm:
+            subprocess.run_pipeline(
+                [sys.executable, '-c', 'pass'],
+                [sys.executable, '-c', 'pass'],
+                capture_output=True, stdout=subprocess.PIPE
+            )
+        self.assertIn('capture_output', str(cm.exception))
+
+    def test_pipeline_universal_newlines(self):
+        """Test that universal_newlines=True works like text=True"""
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c', 'print("hello")'],
+            [sys.executable, '-c', 'import sys; print(sys.stdin.read().upper())'],
+            capture_output=True, universal_newlines=True
+        )
+        self.assertIsInstance(result.stdout, str)
+        self.assertIn('HELLO', result.stdout)
+        self.assertEqual(result.returncodes, [0, 0])
+
+    def test_pipeline_result_repr(self):
+        """Test PipelineResult string representation"""
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c', 'print("test")'],
+            [sys.executable, '-c', 'import sys; print(sys.stdin.read())'],
+            capture_output=True, text=True
+        )
+        repr_str = repr(result)
+        self.assertIn('PipelineResult', repr_str)
+        self.assertIn('commands=', repr_str)
+        self.assertIn('returncodes=', repr_str)
+
+    def test_pipeline_check_returncodes_method(self):
+        """Test PipelineResult.check_returncodes() method"""
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c', 'print("hello")'],
+            [sys.executable, '-c', 'import sys; sys.exit(5)'],
+            capture_output=True
+        )
+        with self.assertRaises(subprocess.PipelineError) as cm:
+            result.check_returncodes()
+        self.assertEqual(cm.exception.returncodes[1], 5)
+
+    def test_pipeline_no_capture(self):
+        """Test pipeline without capturing output"""
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c', 'pass'],
+            [sys.executable, '-c', 'pass'],
+        )
+        self.assertEqual(result.stdout, None)
+        self.assertEqual(result.stderr, None)
+        self.assertEqual(result.returncodes, [0, 0])
+
+    def test_pipeline_stderr_capture(self):
+        """Test that stderr is captured from all processes"""
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c', 'import sys; print("err1", file=sys.stderr); print("out1")'],
+            [sys.executable, '-c', 'import sys; print("err2", file=sys.stderr); print(sys.stdin.read())'],
+            capture_output=True, text=True
+        )
+        self.assertIn('err1', result.stderr)
+        self.assertIn('err2', result.stderr)
+
+    @unittest.skipIf(mswindows, "POSIX specific test")
+    def test_pipeline_timeout(self):
+        """Test pipeline with timeout"""
+        with self.assertRaises(subprocess.TimeoutExpired):
+            subprocess.run_pipeline(
+                [sys.executable, '-c', 'import time; time.sleep(10); print("done")'],
+                [sys.executable, '-c', 'import sys; print(sys.stdin.read())'],
+                capture_output=True, timeout=0.1
+            )
+
+    def test_pipeline_error_str(self):
+        """Test PipelineError string representation"""
+        try:
+            subprocess.run_pipeline(
+                [sys.executable, '-c', 'import sys; sys.exit(1)'],
+                [sys.executable, '-c', 'import sys; sys.exit(2)'],
+                capture_output=True, check=True
+            )
+        except subprocess.PipelineError as e:
+            error_str = str(e)
+            self.assertIn('Pipeline failed', error_str)
+
+    def test_pipeline_explicit_stdout_pipe(self):
+        """Test pipeline with explicit stdout=PIPE"""
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c', 'print("hello")'],
+            [sys.executable, '-c', 'import sys; print(sys.stdin.read().upper())'],
+            stdout=subprocess.PIPE
+        )
+        self.assertEqual(result.stdout.strip(), b'HELLO')
+        self.assertIsNone(result.stderr)
+
+    def test_pipeline_stdin_from_file(self):
+        """Test pipeline with stdin from file"""
+        with tempfile.NamedTemporaryFile(mode='w', delete=False) as f:
+            f.write('file content\n')
+            f.flush()
+            fname = f.name
+        try:
+            with open(fname, 'r') as f:
+                result = subprocess.run_pipeline(
+                    [sys.executable, '-c', 'import sys; print(sys.stdin.read().upper())'],
+                    [sys.executable, '-c', 'import sys; print(len(sys.stdin.read().strip()))'],
+                    stdin=f, capture_output=True, text=True
+                )
+            self.assertEqual(result.stdout.strip(), '12')  # "FILE CONTENT"
+        finally:
+            os.unlink(fname)
+
+    def test_pipeline_stdout_to_devnull(self):
+        """Test pipeline with stdout to DEVNULL"""
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c', 'print("hello")'],
+            [sys.executable, '-c', 'import sys; print(sys.stdin.read())'],
+            stdout=subprocess.DEVNULL
+        )
+        self.assertIsNone(result.stdout)
+        self.assertEqual(result.returncodes, [0, 0])
+
+    def test_pipeline_large_data_no_deadlock(self):
+        """Test that large data doesn't cause pipe buffer deadlock.
+
+        This test verifies that the multiplexed I/O implementation properly
+        handles cases where pipe buffers would fill up. Without proper
+        multiplexing, this would deadlock because:
+        1. First process outputs large data filling stdout pipe buffer
+        2. Middle process reads some, processes, writes to its stdout
+        3. If stdout pipe buffer fills, middle process blocks on write
+        4. But first process is blocked waiting for middle to read more
+        5. Classic deadlock
+
+        The test uses data larger than typical pipe buffer size (64KB on Linux)
+        to ensure the multiplexed I/O is working correctly.
+        """
+        # Generate data larger than typical pipe buffer (64KB)
+        # Use 256KB to ensure we exceed buffer on most systems
+        large_data = 'x' * (256 * 1024)
+
+        # Pipeline: input -> double the data -> count chars
+        # The middle process outputs twice as much, increasing buffer pressure
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c',
+             'import sys; data = sys.stdin.read(); print(data + data)'],
+            [sys.executable, '-c',
+             'import sys; print(len(sys.stdin.read().strip()))'],
+            input=large_data, capture_output=True, text=True, timeout=30
+        )
+
+        # Original data doubled = 512KB = 524288 chars
+        # Second process strips whitespace (removes trailing newline) then counts
+        expected_len = 256 * 1024 * 2  # doubled data, newline stripped
+        self.assertEqual(result.stdout.strip(), str(expected_len))
+        self.assertEqual(result.returncodes, [0, 0])
+
+    def test_pipeline_large_data_three_stages(self):
+        """Test large data through a three-stage pipeline.
+
+        This is a more complex deadlock scenario with three processes,
+        where buffer pressure can occur at multiple points.
+        """
+        # Use 128KB of data
+        large_data = 'y' * (128 * 1024)
+
+        # Pipeline: input -> uppercase -> add prefix to each line -> count
+        # We use line-based processing to create more buffer churn
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c',
+             'import sys; print(sys.stdin.read().upper())'],
+            [sys.executable, '-c',
+             'import sys; print("".join("PREFIX:" + line for line in sys.stdin))'],
+            [sys.executable, '-c',
+             'import sys; print(len(sys.stdin.read()))'],
+            input=large_data, capture_output=True, text=True, timeout=30
+        )
+
+        self.assertEqual(result.returncodes, [0, 0, 0])
+        # Just verify we got a reasonable numeric output without deadlock
+        output_len = int(result.stdout.strip())
+        self.assertGreater(output_len, len(large_data))
+
+    def test_pipeline_large_data_with_stderr(self):
+        """Test large data with large stderr output from multiple processes.
+
+        Ensures stderr collection doesn't interfere with the main data flow
+        and doesn't cause deadlocks when multiple processes write large
+        amounts to stderr concurrently with stdin/stdout data flow.
+        """
+        # 64KB of data through the pipeline
+        data_size = 64 * 1024
+        large_data = 'z' * data_size
+        # Each process writes 64KB to stderr as well
+        stderr_size = 64 * 1024
+
+        result = subprocess.run_pipeline(
+            [sys.executable, '-c', f'''
+import sys
+# Write large stderr output
+sys.stderr.write("E" * {stderr_size})
+sys.stderr.write("\\nstage1 done\\n")
+# Pass through stdin to stdout
+data = sys.stdin.read()
+print(data)
+'''],
+            [sys.executable, '-c', f'''
+import sys
+# Write large stderr output
+sys.stderr.write("F" * {stderr_size})
+sys.stderr.write("\\nstage2 done\\n")
+# Count input size
+data = sys.stdin.read()
+print(len(data.strip()))
+'''],
+            input=large_data, capture_output=True, text=True, timeout=30
+        )
+
+        self.assertEqual(result.stdout.strip(), str(data_size))
+        # Verify both processes wrote to stderr
+        self.assertIn('stage1 done', result.stderr)
+        self.assertIn('stage2 done', result.stderr)
+        # Verify large stderr was captured (at least most of it)
+        self.assertGreater(len(result.stderr), stderr_size)
+        self.assertEqual(result.returncodes, [0, 0])
+
+    def test_pipeline_timeout_large_input(self):
+        """Test that timeout is enforced with large input to a slow pipeline.
+
+        This verifies that run_pipeline() doesn't block indefinitely when
+        writing large input to a pipeline where the first process is slow
+        to consume stdin. The timeout should be enforced promptly.
+
+        This is particularly important on Windows where stdin writing could
+        block without proper threading.
+        """
+        # Input larger than typical pipe buffer (64KB)
+        input_data = 'x' * (128 * 1024)
+
+        start = time.monotonic()
+        with self.assertRaises(subprocess.TimeoutExpired):
+            subprocess.run_pipeline(
+                # First process sleeps before reading - simulates slow consumer
+                [sys.executable, '-c',
+                 'import sys, time; time.sleep(30); print(sys.stdin.read())'],
+                [sys.executable, '-c',
+                 'import sys; print(len(sys.stdin.read()))'],
+                input=input_data, capture_output=True, text=True, timeout=0.5
+            )
+        elapsed = time.monotonic() - start
+
+        # Timeout should occur close to the specified timeout value,
+        # not after waiting for the subprocess to finish sleeping.
+        # Allow generous margin for slow CI, but must be well under
+        # the subprocess sleep time.
+        self.assertLess(elapsed, 5.0,
+            f"TimeoutExpired raised after {elapsed:.2f}s; expected ~0.5s. "
+            "Input writing may have blocked without checking timeout.")
+
+
 def _get_test_grp_name():
     for name_group in ('staff', 'nogroup', 'grp', 'nobody', 'nfsnobody'):
         if grp: