diff --git a/Lib/shutil.py b/Lib/shutil.py
index a4aa0dfdd10b09..aaed61a6b932fd 100644
--- a/Lib/shutil.py
+++ b/Lib/shutil.py
@@ -5,6 +5,7 @@
 """
 
 import os
+import fcntl
 import sys
 import stat
 import fnmatch
@@ -211,6 +212,11 @@ def _samefile(src, dst):
     return (os.path.normcase(os.path.abspath(src)) ==
             os.path.normcase(os.path.abspath(dst)))
 
+def _samefilef(fsrc, fdst):
+    if os.path.abspath(fsrc.name) == os.path.abspath(fdst.name):
+        return True
+    return False
+
 def copyfile(src, dst, *, follow_symlinks=True):
     """Copy data from src to dst in the most efficient way possible.
 
@@ -218,50 +224,109 @@ def copyfile(src, dst, *, follow_symlinks=True):
     symlink will be created instead of copying the file it points to.
 
     """
+
     if _samefile(src, dst):
         raise SameFileError("{!r} and {!r} are the same file".format(src, dst))
 
-    file_size = 0
-    for i, fn in enumerate([src, dst]):
-        try:
-            st = os.stat(fn)
-        except OSError:
-            # File most likely does not exist
-            pass
-        else:
-            # XXX What about other special files? (sockets, devices...)
-            if stat.S_ISFIFO(st.st_mode):
-                raise SpecialFileError("`%s` is a named pipe" % fn)
-            if _WINDOWS and i == 0:
-                file_size = st.st_size
-
+    # XXX Is there a race issue here with os.path.islink() operating on a
+    # path rather than a file descriptor
     if not follow_symlinks and os.path.islink(src):
         os.symlink(os.readlink(src), dst)
+        return dst
+
+    # In Unix, we must open the files non-blocking initially as opening a
+    # FIFO without data present in it will block.
+    if os.name == 'posix':
+        src_flags = os.O_RDONLY | os.O_NONBLOCK
+        dst_flags = os.O_CREAT | os.O_WRONLY | os.O_NONBLOCK
     else:
-        with open(src, 'rb') as fsrc, open(dst, 'wb') as fdst:
-            # macOS
-            if _HAS_FCOPYFILE:
-                try:
-                    _fastcopy_fcopyfile(fsrc, fdst, posix._COPYFILE_DATA)
-                    return dst
-                except _GiveupOnFastCopy:
-                    pass
-            # Linux / Solaris
-            elif _HAS_SENDFILE:
-                try:
-                    _fastcopy_sendfile(fsrc, fdst)
-                    return dst
-                except _GiveupOnFastCopy:
-                    pass
-            # Windows, see:
-            # https://github.com/python/cpython/pull/7160#discussion_r195405230
-            elif _WINDOWS and file_size > 0:
-                _copyfileobj_readinto(fsrc, fdst, min(file_size, COPY_BUFSIZE))
+        src_flags = os.O_RDONLY
+        dst_flags = os.O_WRONLY
+
+    def _src_opener(path, flags):
+        return os.open(path, src_flags)
+
+    # dst's opener is more complex.  We need to atomically check and open the
+    # destination if it doesn't exist.  If it does exist, we need to detect so
+    # we don't destroy it later should we have to fail out for some reason.
+    dst_was_created = False
+    def _dst_opener(path, flags):
+        nonlocal dst_was_created
+        try:
+            dst_was_created = True
+            return os.open(path, dst_flags | os.O_EXCL)
+        except FileExistsError:
+            dst_was_created = False
+            try :
+                # Open the already existing file in as non-blocking
+                fd = os.open(path, dst_flags)
+            # If the destination is already a FIFO for some reason, we'll get an
+            # OSError here as we've opened a FIFO for a non-blocking write with
+            # no reader on the other end.
+            except OSError as e:
+                # Use errno to decide whether the OSError we caught is due to
+                # the above reason or some other reason.  For the above reason,
+                # raise the appropriate special file error.  Otherwise, we need
+                # to re-raise the OSError
+                if e.errno == errno.ENXIO:
+                    raise SpecialFileError("`%s` is a named pipe" % path)
+                else:
+                    raise e
+            # This check is required to catch the case where the destination
+            # file is a FIFO that's we successfully opened non-blocking because
+            # for some reason there was a reader listening preventing an ENXIO
+            # situation.
+            st = os.fstat(fd)
+            if stat.S_ISFIFO(st.st_mode):
+                raise SpecialFileError("`%s` is a named pipe" % path)
+            return fd
+
+    with open(src, 'r', opener=_src_opener) as fsrc, open(dst, 'w', opener=_dst_opener) as fdst:
+        file_size = 0
+        inodes_pre = []
+        # file.name is not populated when using os.fdopen()
+        st = os.fstat(fsrc.fileno())
+        if stat.S_ISFIFO(st.st_mode):
+            # Don't unlink dst unless we created it above
+            if dst_was_created:
+                os.unlink(dst)
+            raise SpecialFileError("`%s` is a named pipe" % src)
+        if _WINDOWS and i == 0:
+            file_size = st.st_size
+
+        # In Unix, we must set the file descriptors back to blocking as that's
+        # what the rest of this function expects.
+        # Additonally, fsrc, and fdst must be turned into file objects
+        if os.name == 'posix':
+            srcfl = fcntl.fcntl(fsrc.fileno(), fcntl.F_GETFL)
+            dstfl = fcntl.fcntl(fdst.fileno(), fcntl.F_GETFL)
+
+            # Unset the non-blocking flag
+            fcntl.fcntl(fsrc.fileno(), fcntl.F_SETFL, srcfl & ~os.O_NONBLOCK)
+            fcntl.fcntl(fdst.fileno(), fcntl.F_SETFL, dstfl & ~os.O_NONBLOCK)
+
+
+        # macOS
+        if _HAS_FCOPYFILE:
+            try:
+                _fastcopy_fcopyfile(fsrc, fdst, posix._COPYFILE_DATA)
                 return dst
-
-            copyfileobj(fsrc, fdst)
-
-    return dst
+            except _GiveupOnFastCopy:
+                pass
+        # Linux / Solaris
+        elif _HAS_SENDFILE:
+            try:
+                _fastcopy_sendfile(fsrc, fdst)
+                return dst
+            except _GiveupOnFastCopy:
+                pass
+        # Windows, see:
+        # https://github.com/python/cpython/pull/7160#discussion_r195405230
+        elif _WINDOWS and file_size > 0:
+            _copyfileobj_readinto(fsrc, fdst, min(file_size, COPY_BUFSIZE))
+            return dst
+        copyfileobj(fsrc, fdst)
+        return dst
 
 def copymode(src, dst, *, follow_symlinks=True):
     """Copy mode bits from src to dst.
diff --git a/Lib/test/test_shutil.py b/Lib/test/test_shutil.py
index 7e0a3292e0f8a4..ba3fa4f2977aca 100644
--- a/Lib/test/test_shutil.py
+++ b/Lib/test/test_shutil.py
@@ -1461,6 +1461,21 @@ def test_copyfile_same_file(self):
         # Make sure file is not corrupted.
         self.assertEqual(read_file(src_file), 'foo')
 
+    def test_copyfile_dst_exists_as_fifo(self):
+        src_dir = self.mkdtemp()
+        src_file = os.path.join(src_dir, 'foo')
+        write_file(src_file, 'foo')
+        dst_dir = src_dir
+        dst_file = os.path.join(dst_dir, 'bar_pipe')
+        try:
+            os.mkfifo(dst_file)
+        except PermissionError as e:
+            self.skipTest('os.mkfifo(): %s' % e)
+        self.assertRaises(shutil.SpecialFileError,
+                          shutil.copyfile,
+                          src_file,
+                          dst_file)
+
     def test_copytree_return_value(self):
         # copytree returns its destination path.
         src_dir = self.mkdtemp()
@@ -1799,7 +1814,7 @@ def _set_shutil_open(self, func):
         self._delete = True
 
     def test_w_source_open_fails(self):
-        def _open(filename, mode='r'):
+        def _open(filename, mode='r', opener=None):
             if filename == 'srcfile':
                 raise OSError('Cannot open "srcfile"')
             assert 0  # shouldn't reach here.
@@ -1813,7 +1828,7 @@ def test_w_dest_open_fails(self):
 
         srcfile = self.Faux()
 
-        def _open(filename, mode='r'):
+        def _open(filename, mode='r', opener=None):
             if filename == 'srcfile':
                 return srcfile
             if filename == 'destfile':
@@ -1834,7 +1849,7 @@ def test_w_dest_close_fails(self):
         srcfile = self.Faux()
         destfile = self.Faux(True)
 
-        def _open(filename, mode='r'):
+        def _open(filename, mode='r', opener=None):
             if filename == 'srcfile':
                 return srcfile
             if filename == 'destfile':
@@ -1857,7 +1872,7 @@ def test_w_source_close_fails(self):
         srcfile = self.Faux(True)
         destfile = self.Faux()
 
-        def _open(filename, mode='r'):
+        def _open(filename, mode='r', opener=None):
             if filename == 'srcfile':
                 return srcfile
             if filename == 'destfile':
diff --git a/Misc/NEWS.d/next/Library/2018-07-07.bpo-30400.Pjhd8.rst b/Misc/NEWS.d/next/Library/2018-07-07.bpo-30400.Pjhd8.rst
new file mode 100644
index 00000000000000..ae50b56fcb4211
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2018-07-07.bpo-30400.Pjhd8.rst
@@ -0,0 +1,2 @@
+Fix race condition in shutil.copyfile() by ensuring the inode of the source
+file does not change while it is being copied.  Patch by Preston Moore.