diff --git a/Misc/NEWS.d/next/Windows/2021-03-09-11-15-41.bpo-43440.igy2Mn.rst b/Misc/NEWS.d/next/Windows/2021-03-09-11-15-41.bpo-43440.igy2Mn.rst
new file mode 100644
index 00000000000000..2116ef3a8718aa
--- /dev/null
+++ b/Misc/NEWS.d/next/Windows/2021-03-09-11-15-41.bpo-43440.igy2Mn.rst
@@ -0,0 +1,2 @@
+Build :mod:`sqlite3` with the ``R*Tree`` module enabled. Patch by Erlend E.
+Aasland.
diff --git a/PCbuild/sqlite3.vcxproj b/PCbuild/sqlite3.vcxproj
index 7351a6dda2c763..39f10c5abd69de 100644
--- a/PCbuild/sqlite3.vcxproj
+++ b/PCbuild/sqlite3.vcxproj
@@ -98,7 +98,7 @@
   <ItemDefinitionGroup>
     <ClCompile>
       <AdditionalIncludeDirectories>$(sqlite3Dir);%(AdditionalIncludeDirectories)</AdditionalIncludeDirectories>
-      <PreprocessorDefinitions>SQLITE_ENABLE_JSON1;SQLITE_ENABLE_FTS4;SQLITE_ENABLE_FTS5;SQLITE_API=__declspec(dllexport);%(PreprocessorDefinitions)</PreprocessorDefinitions>
+      <PreprocessorDefinitions>SQLITE_ENABLE_JSON1;SQLITE_ENABLE_FTS4;SQLITE_ENABLE_FTS5;SQLITE_ENABLE_RTREE;SQLITE_API=__declspec(dllexport);%(PreprocessorDefinitions)</PreprocessorDefinitions>
       <WarningLevel>Level1</WarningLevel>
     </ClCompile>
     <ResourceCompile>