diff --git a/Lib/test/test_typing.py b/Lib/test/test_typing.py
index 82c517a4e600248..1ab3bd248e25cc8 100644
--- a/Lib/test/test_typing.py
+++ b/Lib/test/test_typing.py
@@ -2267,6 +2267,12 @@ def test_no_isinstance(self):
         with self.assertRaises(TypeError):
             issubclass(int, ClassVar)
 
+    def test_bad_module(self):
+        # bpo-41515
+        class BadModule:
+            pass
+        BadModule.__module__ = 'bad' # Something not in sys.modules
+        assert(get_type_hints(BadModule), {})
 
 class FinalTests(BaseTestCase):
 
diff --git a/Lib/typing.py b/Lib/typing.py
index a24c01f0e3b9e36..d9a76d2bb465258 100644
--- a/Lib/typing.py
+++ b/Lib/typing.py
@@ -1628,7 +1628,10 @@ def get_type_hints(obj, globalns=None, localns=None, include_extras=False):
         hints = {}
         for base in reversed(obj.__mro__):
             if globalns is None:
-                base_globals = sys.modules[base.__module__].__dict__
+                try:
+                    base_globals = sys.modules[base.__module__].__dict__
+                except KeyError:
+                    continue
             else:
                 base_globals = globalns
             ann = base.__dict__.get('__annotations__', {})
diff --git a/Misc/NEWS.d/next/Library/2021-04-12-06-01-10.bpo-41515.YaVReb.rst b/Misc/NEWS.d/next/Library/2021-04-12-06-01-10.bpo-41515.YaVReb.rst
new file mode 100644
index 000000000000000..aef5c1791dfeac4
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2021-04-12-06-01-10.bpo-41515.YaVReb.rst
@@ -0,0 +1,2 @@
+Fix :exc:`KeyError` raised in :func:`typing.get_type_hints` due to
+synthetic modules that don't appear in ``sys.modules``.