diff --git a/Lib/pdb.py b/Lib/pdb.py
index 60bdb7675c8131..fb23ae3e6a275d 100755
--- a/Lib/pdb.py
+++ b/Lib/pdb.py
@@ -201,6 +201,7 @@ def forget(self):
         self.stack = []
         self.curindex = 0
         self.curframe = None
+        self.curframe_locals = None
         self.tb_lineno.clear()
 
     def setup(self, f, tb):
diff --git a/Lib/test/test_pdb.py b/Lib/test/test_pdb.py
index 9aa38e08dd6e6c..392f32c362005e 100644
--- a/Lib/test/test_pdb.py
+++ b/Lib/test/test_pdb.py
@@ -1140,6 +1140,39 @@ def test_pdb_issue_20766():
     pdb 2: <built-in function default_int_handler>
     """
 
+def test_pdb_issue_33446():
+    """Test that the destructor of a local variable is traced.
+
+    >>> def test_function():
+    ...     class C:
+    ...         def __del__(self):
+    ...             within_destructor = True
+    ...
+    ...     a = C()
+    ...     import pdb; pdb.Pdb(nosigint=True, readrc=False).set_trace()
+    ...     pass
+
+    >>> with PdbTestInput(['step',
+    ...                    'step',
+    ...                    'step',
+    ...                    'continue']):
+    ...     test_function()
+    > <doctest test.test_pdb.test_pdb_issue_33446[0]>(8)test_function()
+    -> pass
+    (Pdb) step
+    --Return--
+    > <doctest test.test_pdb.test_pdb_issue_33446[0]>(8)test_function()->None
+    -> pass
+    (Pdb) step
+    --Call--
+    > <doctest test.test_pdb.test_pdb_issue_33446[0]>(3)__del__()
+    -> def __del__(self):
+    (Pdb) step
+    > <doctest test.test_pdb.test_pdb_issue_33446[0]>(4)__del__()
+    -> within_destructor = True
+    (Pdb) continue
+    """
+
 
 class PdbTestCase(unittest.TestCase):
     def tearDown(self):
diff --git a/Lib/test/test_sys_settrace.py b/Lib/test/test_sys_settrace.py
index f5125a450511d2..67abef7ba94996 100644
--- a/Lib/test/test_sys_settrace.py
+++ b/Lib/test/test_sys_settrace.py
@@ -447,6 +447,32 @@ def func():
             [(0, 'call'),
              (1, 'line')])
 
+    def test_18_trace_locals_destructors(self):
+        # Issue bpo-33446: destructors of local variables are now traced.
+        def func():
+            class C:
+                def __del__(self):
+                    lineno = 3
+
+            a = C()
+            a = 1
+            lineno = 7
+
+        self.run_and_compare(func,
+           [(0, 'call'),
+            (1, 'line'),
+            (1, 'call'),
+            (1, 'line'),
+            (2, 'line'),
+            (2, 'return'),
+            (5, 'line'),
+            (6, 'line'),
+            (2, 'call'),
+            (3, 'line'),
+            (3, 'return'),
+            (7, 'line'),
+            (7, 'return')])
+
 
 class SkipLineEventsTraceTestCase(TraceTestCase):
     """Repeat the trace tests, but with per-line events skipped"""
diff --git a/Misc/NEWS.d/next/Core and Builtins/2018-05-08-20-37-16.bpo-33446.GQUaqN.rst b/Misc/NEWS.d/next/Core and Builtins/2018-05-08-20-37-16.bpo-33446.GQUaqN.rst
new file mode 100644
index 00000000000000..fd7d0486444bce
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2018-05-08-20-37-16.bpo-33446.GQUaqN.rst	
@@ -0,0 +1 @@
+Destructors of local variables are now traced.
diff --git a/Python/sysmodule.c b/Python/sysmodule.c
index 3fab81aa50536f..80b1467b725b63 100644
--- a/Python/sysmodule.c
+++ b/Python/sysmodule.c
@@ -464,8 +464,21 @@ call_trampoline(PyObject* callback,
 {
     PyObject *result;
     PyObject *stack[3];
-
-    if (PyFrame_FastToLocalsWithError(frame) < 0) {
+    int res;
+    PyThreadState *tstate = PyThreadState_GET();
+    int tracing = tstate->tracing;
+
+    /* frame->f_locals may still hold a reference to an object that was set in
+     * a previous invocation of PyFrame_FastToLocalsWithError() while the
+     * Python code being traced may not anymore hold any reference to this
+     * object. Re-enable temporarily tracing to allow the corresponding
+     * destructor to be traced/profiled (issue bpo-33446). */
+    tstate->tracing = 0;
+    tstate->use_tracing = 1;
+    res = PyFrame_FastToLocalsWithError(frame);
+    tstate->use_tracing = 0;
+    tstate->tracing = tracing;
+    if (res < 0) {
         return NULL;
     }