diff --git a/Misc/NEWS.d/next/Build/2022-10-25-14-43-00.gh-issue-98671.a42a6d.rst b/Misc/NEWS.d/next/Build/2022-10-25-14-43-00.gh-issue-98671.a42a6d.rst
new file mode 100644
index 00000000000000..54b78ed9f2e6f8
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2022-10-25-14-43-00.gh-issue-98671.a42a6d.rst
@@ -0,0 +1,3 @@
+Fix ``NO_MISALIGNED_ACCESSES`` being not defined for the SHA3 extension 
+when ``HAVE_ALIGNED_REQUIRED`` is set. Allowing builds on hardware that 
+unaligned memory accesses are not allowed.
diff --git a/Modules/_sha3/sha3module.c b/Modules/_sha3/sha3module.c
index 3974e0b6b47faa..a2f9d8c75467ae 100644
--- a/Modules/_sha3/sha3module.c
+++ b/Modules/_sha3/sha3module.c
@@ -65,7 +65,7 @@
 #endif
 
 /* Prevent bus errors on platforms requiring aligned accesses such ARM. */
-#if HAVE_ALIGNED_REQUIRED && !defined(NO_MISALIGNED_ACCESSES)
+#if defined(HAVE_ALIGNED_REQUIRED) && !defined(NO_MISALIGNED_ACCESSES)
 #define NO_MISALIGNED_ACCESSES
 #endif