diff --git a/mypyc/irbuild/prepare.py b/mypyc/irbuild/prepare.py
index 61e3e5b95cf4..20f2aeef8e6e 100644
--- a/mypyc/irbuild/prepare.py
+++ b/mypyc/irbuild/prepare.py
@@ -159,7 +159,13 @@ def load_type_map(mapper: Mapper, modules: list[MypyFile], deser_ctx: DeserMaps)
     """Populate a Mapper with deserialized IR from a list of modules."""
     for module in modules:
         for node in module.names.values():
-            if isinstance(node.node, TypeInfo) and is_from_module(node.node, module):
+            if (
+                isinstance(node.node, TypeInfo)
+                and is_from_module(node.node, module)
+                and not node.node.is_newtype
+                and not node.node.is_named_tuple
+                and node.node.typeddict_type is None
+            ):
                 ir = deser_ctx.classes[node.node.fullname]
                 mapper.type_to_ir[node.node] = ir
                 mapper.symbol_fullnames.add(node.node.fullname)
diff --git a/mypyc/test-data/run-multimodule.test b/mypyc/test-data/run-multimodule.test
index 4208af0f04c8..9323612cb4fb 100644
--- a/mypyc/test-data/run-multimodule.test
+++ b/mypyc/test-data/run-multimodule.test
@@ -902,3 +902,51 @@ import native
 [out2]
 0
 None
+
+[case testIncrementalCompilationWithNonClassTypeDef]
+import other_a
+[file other_a.py]
+from other_b import MyInt
+[file other_a.py.2]
+from other_b import MyInt, NT, TD
+i = MyInt(42)
+
+def f(x: MyInt) -> int:
+    return x + 1
+
+def g(x: int) -> MyInt:
+    return MyInt(x + 2)
+
+print(i)
+print(f(i))
+print(g(13))
+
+def make_nt(x: int) -> NT:
+    return NT(x=MyInt(x))
+
+print(make_nt(4))
+
+def make_td(x: int) -> TD:
+    return {"x": MyInt(x)}
+
+print(make_td(5))
+
+[file other_b.py]
+from typing import NewType, NamedTuple, TypedDict
+from enum import Enum
+
+MyInt = NewType("MyInt", int)
+NT = NamedTuple("NT", [("x", MyInt)])
+TD = TypedDict("TD", {"x": MyInt})
+
+[file driver.py]
+import native
+
+[typing fixtures/typing-full.pyi]
+[out]
+[out2]
+42
+43
+15
+NT(x=4)
+{'x': 5}