diff --git a/backends/xnnpack/quantizer/xnnpack_quantizer.py b/backends/xnnpack/quantizer/xnnpack_quantizer.py
index c07d27e4231..3c82a65ad71 100644
--- a/backends/xnnpack/quantizer/xnnpack_quantizer.py
+++ b/backends/xnnpack/quantizer/xnnpack_quantizer.py
@@ -251,6 +251,15 @@ class QuantPattern:
     torch.ops.aten.convolution.default,
 }
 
+CONV_TRANSPOSE_TARGETS = {
+    torch.ops.aten.conv_transpose1d,
+    torch.ops.aten.conv_transpose1d.default,
+    torch.ops.aten.conv_transpose2d,
+    torch.ops.aten.conv_transpose2d.input,
+    torch.ops.aten.conv_transpose3d,
+    torch.ops.aten.conv_transpose3d.input,
+}
+
 LINEAR_TARGETS = {
     torch.ops.aten.linear.default,
 }
@@ -269,14 +278,14 @@ class XNNPACKQuantizer(Quantizer):
     SUPPORTED_PATTERNS = [
         QuantPattern("conv_bn_relu", False, True, CONV_TARGETS),
         QuantPattern("conv_bn", False, True, CONV_TARGETS),
-        QuantPattern("conv_transpose_bn_relu", False, True, CONV_TARGETS),
-        QuantPattern("conv_transpose_bn", False, True, CONV_TARGETS),
+        QuantPattern("conv_transpose_bn_relu", False, True, CONV_TRANSPOSE_TARGETS),
+        QuantPattern("conv_transpose_bn", False, True, CONV_TRANSPOSE_TARGETS),
         QuantPattern("linear_relu", False, False, LINEAR_TARGETS),
         QuantPattern("linear", True, False, LINEAR_TARGETS),
         QuantPattern("conv", True, False, CONV_TARGETS),
-        QuantPattern("conv_transpose", True, False, CONV_TARGETS),
+        QuantPattern("conv_transpose", True, False, CONV_TRANSPOSE_TARGETS),
         QuantPattern("conv_relu", False, False, CONV_TARGETS),
-        QuantPattern("conv_transpose_relu", False, False, CONV_TARGETS),
+        QuantPattern("conv_transpose_relu", False, False, CONV_TRANSPOSE_TARGETS),
         QuantPattern("adaptive_avg_pool2d", False, False, ADAPTIVE_AVG_POOL2D_TARGETS),
         QuantPattern("add_relu", False, False, ADD_TARGETS),
         QuantPattern("add", False, False, ADD_TARGETS),
diff --git a/backends/xnnpack/test/quantizer/test_xnnpack_quantizer.py b/backends/xnnpack/test/quantizer/test_xnnpack_quantizer.py
index 0a317ad8822..84b1a932a5b 100644
--- a/backends/xnnpack/test/quantizer/test_xnnpack_quantizer.py
+++ b/backends/xnnpack/test/quantizer/test_xnnpack_quantizer.py
@@ -120,6 +120,116 @@ def test_conv1d_with_conv2d(self):
             node_list,
         )
 
+    def test_q_tconv_and_conv2d(self):
+        class TConv2dConv2d(torch.nn.Module):
+            def __init__(self):
+                super().__init__()
+                self.first = torch.nn.ConvTranspose2d(
+                    in_channels=1,
+                    out_channels=3,
+                    kernel_size=(3, 3),
+                    padding=1,
+                    bias=False,
+                )
+                self.second = torch.nn.Conv2d(
+                    in_channels=3,
+                    out_channels=2,
+                    kernel_size=(3, 3),
+                    padding=1,
+                    bias=False,
+                )
+
+            def forward(self, x):
+                y = self.first(x)
+                return self.second(y)
+
+            def example_inputs(self):
+                return (torch.randn(1, 1, 3, 3),)
+
+        quantizer = XNNPACKQuantizer()
+        quantization_config = get_symmetric_quantization_config(is_per_channel=True)
+        quantizer.set_operator_type(
+            torch.ops.aten.conv_transpose2d.input, quantization_config
+        )
+        node_occurrence = {
+            # input and output are using quantize_per_tensor and weight is using quantize_per_channel
+            torch.ops.quantized_decomposed.quantize_per_tensor.default: 2,
+            torch.ops.quantized_decomposed.dequantize_per_tensor.default: 2,
+            torch.ops.quantized_decomposed.quantize_per_channel.default: 0,
+            torch.ops.quantized_decomposed.dequantize_per_channel.default: 1,
+        }
+        node_list = [
+            torch.ops.quantized_decomposed.quantize_per_tensor.default,
+            torch.ops.quantized_decomposed.dequantize_per_tensor.default,
+            torch.ops.aten.conv_transpose2d.input,
+            torch.ops.quantized_decomposed.quantize_per_tensor.default,
+            torch.ops.quantized_decomposed.dequantize_per_tensor.default,
+            torch.ops.aten.conv2d.default,
+        ]
+        m = TConv2dConv2d()
+        self._test_quantizer(
+            m,
+            m.example_inputs(),
+            quantizer,
+            node_occurrence,
+            node_list,
+            is_debug_mode=True,
+        )
+
+    def test_q_conv2_and_tconv2d(self):
+        class TConv2dConv2d(torch.nn.Module):
+            def __init__(self):
+                super().__init__()
+                self.first = torch.nn.ConvTranspose2d(
+                    in_channels=1,
+                    out_channels=3,
+                    kernel_size=(3, 3),
+                    padding=1,
+                    bias=False,
+                )
+                self.second = torch.nn.Conv2d(
+                    in_channels=3,
+                    out_channels=2,
+                    kernel_size=(3, 3),
+                    padding=1,
+                    bias=False,
+                )
+
+            def forward(self, x):
+                y = self.first(x)
+                return self.second(y)
+
+            def example_inputs(self):
+                return (torch.randn(1, 1, 3, 3),)
+
+        quantizer = XNNPACKQuantizer()
+        quantization_config = get_symmetric_quantization_config(is_per_channel=True)
+        quantizer.set_operator_type(torch.ops.aten.conv2d.default, quantization_config)
+        node_occurrence = {
+            # input and output are using quantize_per_tensor and weight is using quantize_per_channel
+            torch.ops.quantized_decomposed.quantize_per_tensor.default: 2,
+            torch.ops.quantized_decomposed.dequantize_per_tensor.default: 2,
+            torch.ops.quantized_decomposed.quantize_per_channel.default: 0,
+            torch.ops.quantized_decomposed.dequantize_per_channel.default: 1,
+        }
+        node_list = [
+            torch.ops.aten.conv_transpose2d.input,
+            torch.ops.quantized_decomposed.quantize_per_tensor.default,
+            torch.ops.quantized_decomposed.dequantize_per_tensor.default,
+            torch.ops.aten.conv2d.default,
+            torch.ops.quantized_decomposed.quantize_per_tensor.default,
+            torch.ops.quantized_decomposed.dequantize_per_tensor.default,
+        ]
+        m = TConv2dConv2d()
+        self._test_quantizer(
+            m,
+            m.example_inputs(),
+            quantizer,
+            node_occurrence,
+            node_list,
+            is_debug_mode=True,
+        )
+
     def test_linear(self):
         quantizer = XNNPACKQuantizer()
         quantization_config = get_symmetric_quantization_config(is_per_channel=True)