diff --git a/test/distributed/_pipeline/sync/test_pipe.py b/test/distributed/_pipeline/sync/test_pipe.py
index f45281f5796d..5bc62399114b 100644
--- a/test/distributed/_pipeline/sync/test_pipe.py
+++ b/test/distributed/_pipeline/sync/test_pipe.py
@@ -258,6 +258,31 @@ def forward(self, x):
     assert counter == 2
 
 
+def test_nested_input(setup_rpc):
+    class NestedInput(nn.Module):
+        def __init__(self):
+            super().__init__()
+            self.fc_a = nn.Linear(1, 1)
+            self.fc_b = nn.Linear(1, 1)
+
+        def forward(self, inp):
+            return inp
+
+    model = nn.Sequential(NestedInput())
+    model = Pipe(model, chunks=2)
+
+    a = torch.rand(10, 1, requires_grad=True)
+    b = torch.rand(10, 1, requires_grad=True)
+
+    # TypeError: expected Tensor, but got tuple
+    with pytest.raises(TypeError):
+        model((a, (a, b))).local_value()
+
+    # TypeError: expected Tensor, but got list
+    with pytest.raises(TypeError):
+        model((a, [a, b])).local_value()
+
+
 def test_input_pair(setup_rpc):
     class Two(nn.Module):
         def __init__(self):
@@ -282,6 +307,17 @@ def forward(self, a_and_b):
     assert a.grad is not None
     assert b.grad is not None
 
+    # Test with list.
+    a.grad = None
+    b.grad = None
+    a_out, b_out = model([a, b]).local_value()
+    loss = (a_out + b_out).mean()
+    loss.backward()
+
+    assert a.grad is not None
+    assert b.grad is not None
+
+
 
 def test_input_singleton(setup_rpc):
     class One(nn.Module):
@@ -305,6 +341,18 @@ def forward(self, only_a):
     assert all(p.grad is not None for p in model.parameters())
     assert a.grad is not None
 
+    # Test with list
+    a.grad = None
+    for p in model.parameters():
+        p.grad = None
+
+    (a_out,) = model([a]).local_value()
+    loss = a_out.mean()
+    loss.backward()
+
+    assert all(p.grad is not None for p in model.parameters())
+    assert a.grad is not None
+
 
 def test_input_varargs(setup_rpc):
     model = nn.Sequential(nn.Linear(1, 1))
@@ -336,7 +384,7 @@ def forward(self, _):
         model("hello")
 
 
-def test_non_tensor_tuple(setup_rpc):
+def test_non_tensor_sequence(setup_rpc):
     class NonTensorTuple(nn.Module):
         def forward(self, x):
             return (x, "hello")
@@ -353,6 +401,10 @@ def forward(self, x):
     with pytest.raises(TypeError):
         model((x, "hello"))
 
+    # TypeError: expected Tensor to scatter, but got str
+    with pytest.raises(TypeError):
+        model([x, "hello"])
+
 
 @pytest.mark.parametrize("checkpoint", ["never", "always", "except_last"])
 def test_deferred_batch_norm(checkpoint, setup_rpc):
diff --git a/torch/distributed/_pipeline/sync/balance/__init__.py b/torch/distributed/_pipeline/sync/balance/__init__.py
index 15aa53bc1a2c..8c6da586657f 100644
--- a/torch/distributed/_pipeline/sync/balance/__init__.py
+++ b/torch/distributed/_pipeline/sync/balance/__init__.py
@@ -18,7 +18,7 @@
     pipe = Pipe(model, balance, chunks=8)
 
 """
-from typing import List, Tuple, Union
+from typing import List, Union, Sequence
 
 import torch
 from torch import Tensor
@@ -32,7 +32,7 @@
 
 Device = Union[torch.device, int, str]
 
-Tensors = Tuple[Tensor, ...]
+Tensors = Sequence[Tensor]
 TensorOrTensors = Union[Tensor, Tensors]
 
 
diff --git a/torch/distributed/_pipeline/sync/balance/profile.py b/torch/distributed/_pipeline/sync/balance/profile.py
index 737dda60f6fa..382da988e808 100644
--- a/torch/distributed/_pipeline/sync/balance/profile.py
+++ b/torch/distributed/_pipeline/sync/balance/profile.py
@@ -7,7 +7,7 @@
 """Per-layer profilers."""
 import copy
 import time
-from typing import Generator, List, Tuple, Union
+from typing import Generator, List, Union, Sequence
 
 import torch
 from torch import Tensor
@@ -20,7 +20,7 @@
 
 Device = Union[torch.device, int, str]
 
-Tensors = Tuple[Tensor, ...]
+Tensors = Sequence[Tensor]
 TensorOrTensors = Union[Tensor, Tensors]
 
 
diff --git a/torch/distributed/_pipeline/sync/checkpoint.py b/torch/distributed/_pipeline/sync/checkpoint.py
index bad5eec19469..3f9240793183 100644
--- a/torch/distributed/_pipeline/sync/checkpoint.py
+++ b/torch/distributed/_pipeline/sync/checkpoint.py
@@ -27,7 +27,16 @@
 from collections import deque
 from contextlib import contextmanager
 import threading
-from typing import TYPE_CHECKING, Deque, Generator, List, Optional, Tuple, Union
+from typing import (
+    TYPE_CHECKING,
+    Deque,
+    Generator,
+    List,
+    Optional,
+    Union,
+    Sequence,
+    Tuple
+)
 
 import torch
 from torch import Tensor
@@ -40,7 +49,7 @@
 __all__ = ["is_checkpointing", "is_recomputing"]
 
 
-Tensors = Tuple[Tensor, ...]
+Tensors = Sequence[Tensor]
 TensorOrTensors = Union[Tensor, Tensors]
 
 # Types for shared memory between Checkpoint and Recompute.
diff --git a/torch/distributed/_pipeline/sync/copy.py b/torch/distributed/_pipeline/sync/copy.py
index 3d330f59eeee..07e71a87ce08 100644
--- a/torch/distributed/_pipeline/sync/copy.py
+++ b/torch/distributed/_pipeline/sync/copy.py
@@ -8,7 +8,7 @@
 and computation on the same GPU.
 """
 from collections import deque
-from typing import Deque, List, Optional, Tuple
+from typing import Deque, List, Optional, Tuple, Sequence
 
 import torch
 from torch import Tensor
@@ -18,7 +18,7 @@
 __all__: List[str] = []
 
 
-Tensors = Tuple[Tensor, ...]
+Tensors = Sequence[Tensor]
 
 
 # Common interface between :class:`Copy` and :class:`Wait`.
diff --git a/torch/distributed/_pipeline/sync/microbatch.py b/torch/distributed/_pipeline/sync/microbatch.py
index d38cb6d3b85c..190e1e1f987b 100644
--- a/torch/distributed/_pipeline/sync/microbatch.py
+++ b/torch/distributed/_pipeline/sync/microbatch.py
@@ -6,7 +6,7 @@
 # LICENSE file in the root directory of this source tree.
 """Manipulation of micro-batches."""
 import typing
-from typing import Callable, Iterable, Iterator, List, Tuple, Union, cast
+from typing import Callable, Iterable, Iterator, List, Union, cast, Sequence
 
 import torch
 from torch import Tensor
@@ -15,7 +15,7 @@
 __all__: List[str] = []
 
 
-Tensors = Tuple[Tensor, ...]
+Tensors = Sequence[Tensor]
 TensorOrTensors = Union[Tensor, Tensors]
 Function = Callable[[TensorOrTensors], TensorOrTensors]
 
@@ -139,9 +139,10 @@ def check(input: TensorOrTensors) -> None:
         TypeError: input is not a tensor or tensors.
 
     """
-    if isinstance(input, tuple):
+    if isinstance(input, Sequence):
         for x in input:
-            check(x)
+            if not isinstance(x, Tensor):
+                raise TypeError(f"expected Tensor, but got {input.__class__.__name__}")
         return
 
     if not isinstance(input, Tensor):
diff --git a/torch/distributed/_pipeline/sync/pipe.py b/torch/distributed/_pipeline/sync/pipe.py
index a097e8aa1a9e..82db93060d91 100644
--- a/torch/distributed/_pipeline/sync/pipe.py
+++ b/torch/distributed/_pipeline/sync/pipe.py
@@ -6,7 +6,7 @@
 # LICENSE file in the root directory of this source tree.
 """The Pipe interface."""
 from collections import OrderedDict
-from typing import TYPE_CHECKING, Any, Iterable, List, Optional, Tuple, Union, cast
+from typing import TYPE_CHECKING, Any, Iterable, List, Optional, Tuple, Union, cast, Sequence
 
 import torch
 from torch import Tensor, nn
@@ -27,7 +27,7 @@
 Device = Union[torch.device, int, str]
 Devices = Union[Iterable[Device], List[Device]]
 
-Tensors = Tuple[Tensor, ...]
+Tensors = Sequence[Tensor]
 TensorOrTensors = Union[Tensor, Tensors]
 
 if TYPE_CHECKING:
@@ -310,11 +310,11 @@ def forward(self, input: TensorOrTensors) -> RRef[TensorOrTensors]:  # type: ign
         """:class:`Pipe` is a fairly transparent module wrapper. It doesn't
         modify the input and output signature of the underlying module. But
         there's type restriction. Input and output have to be a
-        :class:`~torch.Tensor` or a tuple of tensors. This restriction is
+        :class:`~torch.Tensor` or a sequence of tensors. This restriction is
         applied at partition boundaries too.
 
         Args:
-            input (torch.Tensor or Tuple[torch.Tensor, ...]): input mini-batch
+            input (torch.Tensor or Sequence[torch.Tensor]): input mini-batch
 
         Returns:
             :class:`~torch.distributed.rpc.RRef` to the output of the mini-batch
diff --git a/torch/distributed/_pipeline/sync/pipeline.py b/torch/distributed/_pipeline/sync/pipeline.py
index 86c8dfddebeb..72c04c6f28d0 100644
--- a/torch/distributed/_pipeline/sync/pipeline.py
+++ b/torch/distributed/_pipeline/sync/pipeline.py
@@ -7,7 +7,7 @@
 """The pipeline parallelism of Pipe."""
 from queue import Queue
 from types import TracebackType
-from typing import TYPE_CHECKING, Iterable, List, Optional, Tuple, Type, Union, cast
+from typing import TYPE_CHECKING, Iterable, List, Optional, Tuple, Type, Union, cast, Sequence
 
 import torch
 from torch import Tensor, nn
@@ -25,7 +25,7 @@
 __all__: List[str] = []
 
 
-Tensors = Tuple[Tensor, ...]
+Tensors = Sequence[Tensor]
 TensorOrTensors = Union[Tensor, Tensors]
 
 ExcInfo = Tuple[Type[BaseException], BaseException, TracebackType]
diff --git a/torch/distributed/_pipeline/sync/skip/skippable.py b/torch/distributed/_pipeline/sync/skip/skippable.py
index 9bb258382b9b..e0b0dae584a2 100644
--- a/torch/distributed/_pipeline/sync/skip/skippable.py
+++ b/torch/distributed/_pipeline/sync/skip/skippable.py
@@ -17,6 +17,7 @@
     List,
     Optional,
     Set,
+    Sequence,
     Tuple,
     Type,
     TypeVar,
@@ -33,7 +34,7 @@
 __all__ = ["skippable", "stash", "pop", "verify_skippables"]
 
 
-Tensors = Tuple[Tensor, ...]
+Tensors = Sequence[Tensor]
 TensorOrTensors = Union[Tensor, Tensors]
 
 StashPop = Union["stash", "pop"]