diff --git a/test/test_testing.py b/test/test_testing.py
index b87345186cb3..9285166cb15e 100644
--- a/test/test_testing.py
+++ b/test/test_testing.py
@@ -3,9 +3,9 @@
 import math
 
 from torch.testing._internal.common_utils import \
-    (TestCase, run_tests, make_tensor)
+    (TestCase, make_tensor, run_tests, slowTest)
 from torch.testing._internal.common_device_type import \
-    (instantiate_device_type_tests, onlyOnCPUAndCUDA, dtypes)
+    (instantiate_device_type_tests, onlyCUDA, onlyOnCPUAndCUDA, dtypes)
 
 # For testing TestCase methods and torch.testing functions
 class TestTesting(TestCase):
@@ -438,6 +438,54 @@ def test_assert_messages(self, device):
         self.assertEqual("no_user_msg", self._get_assert_msg(msg=None, debug_msg="no_user_msg"))
         self.assertEqual("debug_msg\nuser_msg", self._get_assert_msg(msg="user_msg", debug_msg="debug_msg"))
 
+    @onlyCUDA
+    @slowTest
+    def test_cuda_assert_should_stop_test_suite(self, device):
+        # This test is slow because it spawn another process to run another test suite.
+        import subprocess
+        import sys
+
+        problematic_test_script = """\
+#!/usr/bin/env python
+
+import torch
+
+from torch.testing._internal.common_utils import (TestCase, run_tests)
+from torch.testing._internal.common_device_type import instantiate_device_type_tests
+
+# This test is added to ensure that test suite terminates early when
+# CUDA assert was thrown since all subsequent test will fail.
+# See: https://github.com/pytorch/pytorch/issues/49019
+# This test file should be invoked from test_testing.py
+class TestThatContainsCUDAAssertFailure(TestCase):
+
+    def test_throw_unrecoverable_cuda_exception(self, device):
+        x = torch.rand(10, device=device)
+        # cause unrecoverable CUDA exception, recoverable on CPU
+        y = x[torch.tensor([25])].cpu()
+
+    def test_trivial_passing_test_case_on_cpu_cuda(self, device):
+        x1 = torch.tensor([0., 1.], device=device)
+        x2 = torch.tensor([0., 1.], device='cpu')
+        self.assertEqual(x1, x2)
+
+instantiate_device_type_tests(
+    TestThatContainsCUDAAssertFailure,
+    globals(),
+    except_for=None
+)
+
+if __name__ == '__main__':
+    run_tests()
+"""
+
+        # Test running of cuda assert test suite should early terminate.
+        p = subprocess.run([sys.executable, '-c', problematic_test_script], capture_output=True, timeout=120)
+        # should capture CUDA error
+        self.assertIn('CUDA error: device-side assert triggered', p.stderr.decode('ascii'))
+        # should run only 3 tests - 2 CPUs and 1 CUDA (remaining CUDA test should skip)
+        self.assertIn('Ran 3 tests', p.stderr.decode('ascii'))
+
 instantiate_device_type_tests(TestTesting, globals())
 
 if __name__ == '__main__':
diff --git a/torch/testing/_internal/common_device_type.py b/torch/testing/_internal/common_device_type.py
index 36f02eff0c0f..73185116a4f5 100644
--- a/torch/testing/_internal/common_device_type.py
+++ b/torch/testing/_internal/common_device_type.py
@@ -187,6 +187,9 @@ def _construct_test_name(test_name, op, device_type, dtype):
 class DeviceTypeTestBase(TestCase):
     device_type: str = 'generic_device_type'
 
+    # Flag to disable test suite early due to unrecoverable error such as CUDA error.
+    _stop_test_suite = False
+
     # Precision is a thread-local setting since it may be overridden per test
     _tls = threading.local()
     _tls.precision = TestCase._precision
@@ -271,6 +274,11 @@ def instantiated_test(self, name=name, test=test_fn, dtype=dtype, op=op):
                     self.precision = self._get_precision_override(test_fn, dtype)
                     args = (arg for arg in (device_arg, dtype, op) if arg is not None)
                     result = test_fn(self, *args)
+                except RuntimeError as rte:
+                    if 'CUDA error: device-side assert triggered' in rte.__repr__():
+                        self._stop_test_suite = True
+                    # raise the runtime error as is.
+                    raise rte
                 finally:
                     self.precision = guard_precision
 
@@ -313,6 +321,12 @@ def instantiated_test(self, name=name, test=test_fn, dtype=dtype, op=op):
             for dtype in dtypes:
                 instantiate_test_helper(cls, name, test=test, dtype=dtype, op=None)
 
+    def run(self, result=None):
+        super().run(result=result)
+        # Early terminate test if _stop_test_suite is set.
+        if self._stop_test_suite:
+            result.stop()
+
 
 class CPUTestBase(DeviceTypeTestBase):
     device_type = 'cpu'