diff --git a/.appveyor.yml b/.appveyor.yml
index af7236b6a4..80900c9a4f 100644
--- a/.appveyor.yml
+++ b/.appveyor.yml
@@ -77,27 +77,28 @@ install:
   - sed -i "s/pandas==.*/pandas==%PANDAS_VERSION%/" etc/requirements.txt
   - sed -i "s/scipy==.*/scipy==%SCIPY_VERSION%/" etc/requirements.txt
   - IF NOT "%PANDAS_DATAREADER_VERSION%"=="" sed -i "s/pandas-datareader==.*/pandas-datareader==%PANDAS_DATAREADER_VERSION%/" etc/requirements.txt
-  - IF NOT "%DASK_VERSION%"=="" sed -i "s/dask\[dataframe\]==.*/dask\[dataframe\]==%DASK_VERSION%/" etc/requirements_blaze.txt
+  - IF NOT "%DASK_VERSION%"=="" sed -i "s/dask\[dataframe\]==.*/dask\[dataframe\]==%DASK_VERSION%/" etc/requirements.txt
   - cat etc/requirements.txt
   - conda info -a
   - conda install conda=4.3.30 conda-build=3.0.28 anaconda-client=1.6.3 --yes -q
   - conda list
   # https://blog.ionelmc.ro/2014/12/21/compiling-python-extensions-on-windows/ for 64bit C compilation
   - ps: copy .\ci\appveyor\vcvars64.bat "C:\Program Files (x86)\Microsoft Visual Studio 10.0\VC\bin\amd64"
+  - "ECHO APPVEYOR_PULL_REQUEST_NUMBER is: %APPVEYOR_PULL_REQUEST_NUMBER%"
   - "%CMD_IN_ENV% python .\\ci\\make_conda_packages.py"
 
   # test that we can conda install zipline in a new env
   - conda create -n installenv --yes -q --use-local python=%PYTHON_VERSION% numpy=%NUMPY_VERSION% zipline -c quantopian -c https://conda.anaconda.org/quantopian/label/ci
 
-  - ps: $env:BCOLZ_VERSION=(sls "bcolz==(.*)" .\etc\requirements.txt -ca).matches.groups[1].value
-  - ps: $env:NUMEXPR_VERSION=(sls "numexpr==(.*)" .\etc\requirements.txt -ca).matches.groups[1].value
-  - ps: $env:PYTABLES_VERSION=(sls "tables==(.*)" .\etc\requirements.txt -ca).matches.groups[1].value
-  - ps: $env:H5PY_VERSION=(sls "h5py==(.*)" .\etc\requirements.txt -ca).matches.groups[1].value
-  - ps: $env:TALIB_VERSION=(sls "TA-Lib==(.*)" .\etc\requirements_talib.txt -ca).matches.groups[1].value
-  # We conda install certifi at the pinned exact version because it is a transitive dependency of zipline via requests and uses distutils for packaging. 
+  - ps: $env:BCOLZ_VERSION=(sls "bcolz==([^ ]*)" .\etc\requirements.txt -ca).matches.groups[1].value
+  - ps: $env:NUMEXPR_VERSION=(sls "numexpr==([^ ]*)" .\etc\requirements.txt -ca).matches.groups[1].value
+  - ps: $env:PYTABLES_VERSION=(sls "tables==([^ ]*)" .\etc\requirements.txt -ca).matches.groups[1].value
+  - ps: $env:H5PY_VERSION=(sls "h5py==([^ ]*)" .\etc\requirements.txt -ca).matches.groups[1].value
+  - ps: $env:TALIB_VERSION=(sls "ta-lib==([^ ]*)" .\etc\requirements.txt -ca).matches.groups[1].value
+  # We conda install certifi at the pinned exact version because it is a transitive dependency of zipline via requests and uses distutils for packaging.
   # Since conda installs latest certifi by default, we would fail to uninstall that new version when trying to install the pinned version using pip later in the build:
   # "Cannot uninstall 'certifi'. It is a distutils installed project and thus we cannot accurately determine which files belong to it which would lead to only a partial uninstall."
-  - ps: $env:CERTIFI_VERSION=(sls "certifi==(.*)" .\etc\requirements.txt -ca).matches.groups[1].value
+  - ps: $env:CERTIFI_VERSION=(sls "certifi==([^ ]*)" .\etc\requirements.txt -ca).matches.groups[1].value
   - conda create -n testenv --yes -q --use-local "pip<19" python=%PYTHON_VERSION% numpy=%NUMPY_VERSION% pandas=%PANDAS_VERSION% scipy=%SCIPY_VERSION% ta-lib=%TALIB_VERSION% bcolz=%BCOLZ_VERSION% numexpr=%NUMEXPR_VERSION% pytables=%PYTABLES_VERSION% h5py=%H5PY_VERSION% certifi=%CERTIFI_VERSION% -c quantopian -c https://conda.anaconda.org/quantopian/label/ci
   - activate testenv
   - bash etc/dev-install --cache-dir=%LOCALAPPDATA%\pip\Cache\pip_np%CONDA_NPY%py%CONDA_PY%
diff --git a/.github/workflows/ci.yaml b/.github/workflows/ci.yaml
new file mode 100644
index 0000000000..01da88d698
--- /dev/null
+++ b/.github/workflows/ci.yaml
@@ -0,0 +1,108 @@
+name: Zipline CI
+on:
+  push:
+    branches:
+      - master
+  pull_request:
+    branches:
+      - master
+
+jobs:
+  build-and-test:
+    name: build (${{ matrix.os }}, ${{ matrix.python-version }}, ${{ matrix.pandas-version }})
+    runs-on: ${{ matrix.os }}
+    strategy:
+      fail-fast: false
+      matrix:
+        os: [ubuntu-latest]  # TODO: Add windows-latest, macos-latest
+        python-version: [2.7, 3.5]
+        pandas-version: [0.18.1, 0.22.0]
+        include:  # TODO: Add 3.7, 3.8
+          - python-version: 2.7  # py2.7, old pandas
+            pandas-version: 0.18.1
+            numpy-version: 1.11.3
+            scipy-version: 0.17.1
+          - python-version: 3.5  # py3.5, new pandas
+            pandas-version: 0.18.1
+            numpy-version: 1.11.3
+            scipy-version: 0.17.1
+          - python-version: 3.5  # py3.5, new pandas
+            pandas-version: 0.22.0
+            numpy-version: 1.14.1
+            scipy-version: 1.0.0
+        exclude:
+          - python-version: 2.7
+            pandas-version: 0.22.0
+    env:
+      PYTHON_VERSION: ${{ matrix.python-version }}
+      PANDAS_VERSION: ${{ matrix.pandas-version }}
+      NUMPY_VERSION: ${{ matrix.numpy-version }}
+      SCIPY_VERSION: ${{ matrix.scipy-version }}
+    steps:
+      - name: Checkout repository
+        uses: actions/checkout@v2
+      - name: Pip cache
+        uses: actions/cache@v1
+        with:
+          path: ~/.cache/.pip
+          key: ${{ matrix.os }}-${{ matrix.python-version }}-${{ matrix.pandas-version }}-${{ hashFiles('**/requirements.txt') }}-pip-cache
+      - name: Install dependencies
+        run: |
+          if [ "$PANDAS_VERSION" = "0.22.0" ]; then
+            PANDAS_DATAREADER_VERSION=0.4.0 DASK_VERSION=0.17.1
+          fi
+          source ./ci/actions/overwrite_requirements.sh
+          cat etc/requirements.txt
+
+          etc/dev-install --user --cache-dir="$HOME/.cache/.pip/pip_np$CONDA_NPY"
+          pip freeze | sort
+
+          echo "::set-env name=PATH::$PATH"
+      - name: Lint
+        run: |
+          source ./testenv/bin/activate
+          flake8 zipline tests
+      - name: Tests
+        run: |
+          source ./testenv/bin/activate
+          nosetests --with-coverage
+
+  conda-build:
+    name: conda build (${{ matrix.os }}, ${{ matrix.python-version }}, ${{ matrix.pandas-version }})
+    runs-on: ${{ matrix.os }}
+    strategy:
+      fail-fast: false
+      matrix:
+        os: [ubuntu-latest]
+        python-version: [2.7, 3.5]  # TODO: Add 3.7, 3.8
+        include:
+          - python-version: 2.7  # py2.7, old pandas
+            pandas-version: 0.18.1
+            numpy-version: 1.11.3
+            scipy-version: 0.17.1
+          - python-version: 3.5  # py3.5, new pandas
+            pandas-version: 0.18.1
+            numpy-version: 1.11.3
+            scipy-version: 0.17.1
+          - python-version: 3.5  # py3.5, new pandas
+            pandas-version: 0.22.0
+            numpy-version: 1.14.1
+            scipy-version: 1.0.0
+            dask-version: 0.17.1
+            pandas-datareader-version: 0.4.0
+    env:
+      # https://help.github.com/en/actions/automating-your-workflow-with-github-actions/creating-and-using-encrypted-secrets#creating-encrypted-secrets
+      ANACONDA_TOKEN: ${{ secrets.AnacondaToken }}
+      CONDA_ROOT_PYTHON_VERSION: "2.7"
+    steps:
+          - name: Checkout repository
+            uses: actions/checkout@v2
+          - name: Unshallow clone  # Unshallow the clone so the conda build can clone it.
+            run: git fetch --unshallow --tags
+          - name: Install miniconda
+            run: |
+              source ./ci/actions/install_miniconda.sh
+
+              conda info -a
+              conda install conda=4.3.30 conda-build=3.0.28 anaconda-client=1.6.3 --yes -q
+              conda list
\ No newline at end of file
diff --git a/.travis.yml b/.travis.yml
index 5bf2c69c72..97f06d836f 100644
--- a/.travis.yml
+++ b/.travis.yml
@@ -55,8 +55,8 @@ install:
   - conda install conda=4.3.30 conda-build=3.0.28 anaconda-client=1.6.3 --yes -q
   - conda list
 
-  - TALIB_VERSION=$(cat ./etc/requirements_talib.txt | sed "s/TA-Lib==\(.*\)/\1/")
-  - CERTIFI_VERSION=$(cat ./etc/requirements.txt | grep "certifi" | sed "s/certifi==\(.*\)/\1/")
+  - TALIB_VERSION=$(cat ./etc/requirements.txt | grep "ta-lib" | sed "s/ta-lib==\([^ ]*\) *.*/\1/")
+  - CERTIFI_VERSION=$(cat ./etc/requirements.txt | grep "certifi" | sed "s/certifi==\([^ ]*\) *.*/\1/")
   - IFS='.' read -r -a NPY_VERSION_ARR <<< "$NUMPY_VERSION"
   - CONDA_NPY=${NPY_VERSION_ARR[0]}${NPY_VERSION_ARR[1]}
   - CONDA_PY=$TRAVIS_PYTHON_VERSION
@@ -73,7 +73,7 @@ install:
   # Make sure stdout is in blocking mode. If we don't, then conda create will barf during downloads.
   # See https://github.com/travis-ci/travis-ci/issues/4704#issuecomment-348435959 for details.
   - python -c 'import os,sys,fcntl; flags = fcntl.fcntl(sys.stdout, fcntl.F_GETFL); fcntl.fcntl(sys.stdout, fcntl.F_SETFL, flags&~os.O_NONBLOCK);'
-  # We conda install certifi at the pinned exact version because it is a transitive dependency of zipline via requests and uses distutils for packaging. 
+  # We conda install certifi at the pinned exact version because it is a transitive dependency of zipline via requests and uses distutils for packaging.
   # Since conda installs latest certifi by default, we would fail to uninstall that new version when trying to install the pinned version using pip later in the build:
   # "Cannot uninstall 'certifi'. It is a distutils installed project and thus we cannot accurately determine which files belong to it which would lead to only a partial uninstall."
   - conda create -n testenv --use-local --yes -c quantopian -c quantopian/label/ci pip python=$TRAVIS_PYTHON_VERSION numpy=$NUMPY_VERSION pandas=$PANDAS_VERSION scipy=$SCIPY_VERSION ta-lib=$TALIB_VERSION libgfortran=3.0 certifi=$CERTIFI_VERSION
diff --git a/ci/actions/install_miniconda.sh b/ci/actions/install_miniconda.sh
new file mode 100644
index 0000000000..5a4ff201cf
--- /dev/null
+++ b/ci/actions/install_miniconda.sh
@@ -0,0 +1,12 @@
+#!/bin/bash
+
+if [[ "$RUNNER_OS" == "macOS" ]]; then
+    MINICONDA_OS=MacOSX
+else
+    MINICONDA_OS=Linux
+fi
+
+wget "https://repo.continuum.io/miniconda/Miniconda${CONDA_ROOT_PYTHON_VERSION:0:1}-4.3.30-$MINICONDA_OS-x86_64.sh" -O miniconda.sh
+chmod +x miniconda.sh
+./miniconda.sh -b -p $HOME/miniconda
+export PATH="$HOME/miniconda/bin:$PATH"
diff --git a/ci/actions/overwrite_requirements.sh b/ci/actions/overwrite_requirements.sh
new file mode 100644
index 0000000000..7b83063c44
--- /dev/null
+++ b/ci/actions/overwrite_requirements.sh
@@ -0,0 +1,22 @@
+#!/bin/bash
+
+if [[ "$RUNNER_OS" == "macOS" ]]; then
+    # On OSX, sed refuses to edit in place, so give it an empty extension for the rename.
+    function sed_inplace() {
+        sed -i '' "$@"
+    }
+else
+    function sed_inplace() {
+        sed -i "$@"
+    }
+fi
+
+sed_inplace "s/numpy==.*/numpy==$NUMPY_VERSION/" etc/requirements.txt
+sed_inplace "s/pandas==.*/pandas==$PANDAS_VERSION/" etc/requirements.txt
+sed_inplace "s/scipy==.*/scipy==$SCIPY_VERSION/" etc/requirements.txt
+if [ -n matrix.pandas-datareader-version ]; then
+    sed_inplace "s/pandas-datareader==.*/pandas-datareader==$PANDAS_DATAREADER_VERSION/" etc/requirements.txt
+fi
+if [ -n matrix.dask-version ]; then
+    sed_inplace "s/dask\[dataframe\]==.*/dask\[dataframe\]==$DASK_VERSION/" etc/requirements.txt
+fi
diff --git a/ci/make_conda_packages.py b/ci/make_conda_packages.py
index e18f4024a8..eddf06a243 100644
--- a/ci/make_conda_packages.py
+++ b/ci/make_conda_packages.py
@@ -64,6 +64,6 @@ def main(env, do_upload):
 if __name__ == '__main__':
     env = os.environ.copy()
     main(env,
-         do_upload=((env.get('ANACONDA_TOKEN')
-                     and env.get('APPVEYOR_REPO_BRANCH') == 'master')
-                    and 'APPVEYOR_PULL_REQUEST_NUMBER' not in env))
+         do_upload=(env.get('ANACONDA_TOKEN')
+                    and env.get('APPVEYOR_REPO_BRANCH') == 'master'
+                    and not env.get('APPVEYOR_PULL_REQUEST_NUMBER')))
diff --git a/ci/travis/overwrite_requirements.sh b/ci/travis/overwrite_requirements.sh
index fc2a1fdd51..cb2d3f5797 100644
--- a/ci/travis/overwrite_requirements.sh
+++ b/ci/travis/overwrite_requirements.sh
@@ -18,5 +18,5 @@ if [ -n "$PANDAS_DATAREADER_VERSION" ]; then
     sed_inplace "s/pandas-datareader==.*/pandas-datareader==$PANDAS_DATAREADER_VERSION/" etc/requirements.txt
 fi
 if [ -n "$DASK_VERSION" ]; then
-    sed_inplace "s/dask\[dataframe\]==.*/dask\[dataframe\]==$DASK_VERSION/" etc/requirements_blaze.txt
+    sed_inplace "s/dask\[dataframe\]==.*/dask\[dataframe\]==$DASK_VERSION/" etc/requirements.txt
 fi
diff --git a/conda/README.md b/conda/README.md
index 80340491a3..9d88094a0f 100644
--- a/conda/README.md
+++ b/conda/README.md
@@ -12,7 +12,6 @@ conda-build you should be able to:
 ```bash
 conda build ta-lib
 conda build logbook
-conda build cyordereddict
 conda build zipline
 ```
 
diff --git a/conda/cyordereddict/meta.yaml b/conda/cyordereddict/meta.yaml
deleted file mode 100644
index 775d7ca214..0000000000
--- a/conda/cyordereddict/meta.yaml
+++ /dev/null
@@ -1,63 +0,0 @@
-{% set name = "cyordereddict" %}
-{% set version = "0.2.2" %}
-{% set file_ext = "tar.gz" %}
-{% set hash_type = "sha256" %}
-{% set hash_value = "f8387caaffba695d704311842291ede696080a5ed306f07f1825de126fb7f1ec" %}
-
-package:
-  name: '{{ name|lower }}'
-  version: '{{ version }}'
-
-source:
-  fn: '{{ name }}-{{ version }}.{{ file_ext }}'
-  url: https://pypi.io/packages/source/{{ name[0] }}/{{ name }}/{{ name }}-{{ version }}.{{ file_ext }}
-  '{{ hash_type }}': '{{ hash_value }}'
-
-build:
-  number: 0
-  script: 'python setup.py install '
-
-requirements:
-  build:
-    - python
-  run:
-    - python
-
-test:
-  imports:
-    - cyordereddict
-    - cyordereddict.benchmark
-
-about:
-  home: https://github.com/shoyer/cyordereddict
-  license: BSD License
-  license_family: BSD
-  license_file: ''
-  summary: Cython implementation of Python's collections.OrderedDict
-  description: "**This library is obsolete!** Python 3.5's ``collections.OrderedDict`` was `rewritten in C`_, and is now significantly faster than ``cyordereddict.OrderedDict`` for almost all operations.\n\
-    \n.. _rewritten in C: https://bugs.python.org/issue16991\n\n=============\ncyordereddict\n=============\n\n.. image:: https://travis-ci.org/shoyer/cyordereddict.svg?branch=master\n    :target: https://travis-ci.org/shoyer/cyordereddict\n\
-    \n.. image:: https://badge.fury.io/py/cyordereddict.svg\n    :target: https://pypi.python.org/pypi/cyordereddict\n\nThe Python standard library's ``OrderedDict`` ported to Cython. A drop-in\nreplacement\
-    \ that is 2-6x faster.\n\nInstall:\n    ``pip install cyordereddict``\n\nDependencies:\n    CPython (2.6, 2.7, 3.3 or 3.4) and a C compiler. Cython is only required\n    for the dev version.\n\nUse:\n\
-    \    .. code-block:: python\n\n        from cyordereddict import OrderedDict\n\nBenchmarks:\n    Python 2.7:\n\n    ==================  =================================  =========================\n\
-    \    Test                Code                                 Ratio (stdlib / cython)\n    ==================  =================================  =========================\n    ``__init__`` empty  ``OrderedDict()``\
-    \                                        1.8\n    ``__init__`` list   ``OrderedDict(list_data)``                               4.8\n    ``__init__`` dict   ``OrderedDict(dict_data)``               \
-    \                4.6\n    ``__setitem__``     ``ordereddict[0] = 0``                                   8.6\n    ``__getitem__``     ``ordereddict[0]``                                       3\n    ``update``\
-    \          ``ordereddict.update(dict_data)``                        5.5\n    ``__iter__``        ``list(ordereddict)``                                    5.6\n    ``items``           ``ordereddict.items()``\
-    \                                  5.9\n    ``__contains__``    ``0 in ordereddict``                                     2.3\n    ==================  =================================  =========================\n\
-    \n    Python 3.4:\n\n    ==================  =================================  =========================\n    Test                Code                                 Ratio (stdlib / cython)\n    ==================\
-    \  =================================  =========================\n    ``__init__`` empty  ``OrderedDict()``                                        1.5\n    ``__init__`` list   ``OrderedDict(list_data)``\
-    \                               3.9\n    ``__init__`` dict   ``OrderedDict(dict_data)``                               4.2\n    ``__setitem__``     ``ordereddict[0] = 0``                            \
-    \       8.4\n    ``__getitem__``     ``ordereddict[0]``                                       2.9\n    ``update``          ``ordereddict.update(dict_data)``                        6.5\n    ``__iter__``\
-    \        ``list(ordereddict)``                                    2.3\n    ``items``           ``list(ordereddict.items())``                            2.1\n    ``__contains__``    ``0 in ordereddict``\
-    \                                     2.3\n    ==================  =================================  =========================\n    To run these yourself, use ``cyordereddict.benchmark()``\n\nCavaets:\n\
-    \    ``cyorderedddict.OrderedDict`` is an extension type (similar to the\n    built-in ``dict``) instead of a Python class. This is necessary for speed,\n    but means that in a few pathological cases\
-    \ its behavior will differ from\n    ``collections.OrderedDict``:\n\n    * The ``inspect`` module does not work on ``cyorderedddict.OrderedDict``\n      methods.\n    * Extension types use slots instead\
-    \ of dictionaries, so you cannot add\n      custom attributes without making a subclass (e.g.,\n      ``OrderedDict.foo = 'bar'`` will fail).\n\n    You can do anything else you might do with an OrderedDict,\
-    \ including\n    subclassing: everything else passes the ``collections.OrderedDict`` test\n    suite. We based the Cython code directly on the Python standard library,\n    and thus use separate code\
-    \ bases for Python 2 and 3, specifically to\n    reduce the potential for introducing new bugs or performance regressions.\n\nLicense:\n    MIT. Based on the Python standard library, which is under\
-    \ the Python\n    Software Foundation License."
-  doc_url: ''
-  dev_url: ''
-
-extra:
-  recipe-maintainers: ''
diff --git a/docs/source/development-guidelines.rst b/docs/source/development-guidelines.rst
index f1f3535ff0..2491835194 100644
--- a/docs/source/development-guidelines.rst
+++ b/docs/source/development-guidelines.rst
@@ -20,7 +20,7 @@ First, you'll need to clone Zipline by running:
 Then check out to a new branch where you can make your changes:
 
 .. code-block:: bash
-		
+
    $ git checkout -b some-short-descriptive-name
 
 If you don't already have them, you'll need some C library dependencies. You can follow the `install guide`__ to get the appropriate dependencies.
@@ -117,12 +117,12 @@ Then run ``pip install`` TA-lib:
 
 .. code-block:: bash
 
-   $ pip install -r ./etc/requirements_talib.txt
+   $ pip install -r ./etc/requirements_talib.in -c ./etc/requirements.txt
 
 You should now be free to run tests:
 
 .. code-block:: bash
-		
+
    $ nosetests
 
 
@@ -141,10 +141,45 @@ __ https://ci.appveyor.com/project/quantopian/zipline
 
 Packaging
 ---------
+
 To learn about how we build Zipline conda packages, you can read `this`__ section in our release process notes.
 
 __ release-process.html#uploading-conda-packages
-   
+
+
+Updating dependencies
+---------------------
+
+If you update the zipline codebase so that it now depends on a new version of a library,
+then you should update the lower bound on that dependency in ``etc/requirements.in``
+(or ``etc/requirements_dev.in`` as appropriate).
+We use `pip-compile`__ to find mutually compatible versions of dependencies for the
+``etc/requirements.txt`` lockfile used in our CI environments.
+
+__ https://github.com/jazzband/pip-tools/
+
+When you update a dependency in an ``.in`` file,
+you need to re-run the ``pip-compile`` command included in the header of `the lockfile`__;
+otherwise the lockfile will not meet the constraints specified to pip by zipline
+at install time (via ``etc/requirements.in`` via ``setup.py``).
+
+__ https://github.com/quantopian/zipline/tree/master/etc/requirements.txt
+
+If the zipline codebase can still support an old version of a dependency, but you want
+to update to a newer version of that library in our CI environments, then only the
+lockfile needs updating. To update the lockfile without bumping the lower bound,
+re-run the ``pip-compile`` command included in the header of the lockfile with the
+addition of the ``--upgrade-package`` or ``-P`` `flag`__, e.g.
+
+__ https://github.com/jazzband/pip-tools/#updating-requirements
+
+.. code-block:: bash
+
+   $ pip-compile --output-file=etc/reqs.txt etc/reqs.in ... -P six==1.13.0 -P "click>4.0.0"
+
+As you can see above, you can include multiple such constraints in a single invocation of ``pip-compile``.
+
+
 Contributing to the Docs
 ------------------------
 
@@ -209,7 +244,7 @@ __ https://git-scm.com/book/en/v2/Distributed-Git-Contributing-to-a-Project
 
    At least one of those calculations, max_leverage, was causing a
    divide by zero error.
-   
+
    Instead of papering over that error, the entire calculation was
    a bit suspect so removing, with possibility of adding it back in
    later with handling the case (or raising appropriate errors) when
diff --git a/etc/dev-install b/etc/dev-install
index 3f56f62c49..410ff1b9df 100755
--- a/etc/dev-install
+++ b/etc/dev-install
@@ -34,22 +34,16 @@ fi
 
 # These have to be installed first so that the other requirements can be
 # compiled against the specific versions we use.
-python -m pip install numpy Cython -c etc/requirements.txt $@
+python -m pip install -r etc/requirements_build.in -c etc/requirements.txt $@
 
 # XXX: bcolz has to be compiled against our specific version of numpy:
 # by default, it uses an incompatible pre-compiled binary.
-python -m pip install --no-binary=bcolz -r etc/requirements.txt -c etc/requirements.txt $@
+python -m pip install --no-binary=bcolz -e .[all] -r etc/requirements_blaze.in -c etc/requirements.txt $@
 
 # TODO: resolve these error messages:
 # flake8 3.6.0 has requirement setuptools>=30, but you'll have setuptools 28.8.0 which is incompatible.
 # blaze keepalive-30.g31060532 has requirement odo>=0.5.0, but you'll have odo 0.3.2+729.gda7f26d which is incompatible.
 
-python -m pip install -r etc/requirements_dev.txt -c etc/requirements.txt $@
-python -m pip install -r etc/requirements_blaze.txt -c etc/requirements.txt $@
-
-# All requirements should already be satisfied by this point.
-python -m pip install -e .[all] -c etc/requirements.txt $@
-
 echo
 echo "Installation complete! Try running 'zipline --help'."
 echo
diff --git a/etc/goodies.txt b/etc/goodies.txt
deleted file mode 100644
index f472c3ae71..0000000000
--- a/etc/goodies.txt
+++ /dev/null
@@ -1,7 +0,0 @@
-# Extra modules, goodies for algorithms.
-
-matplotlib==1.5.3
-scipy==0.12.0
-scikit-learn==0.13.1
-statsmodels==0.5.0
-patsy==0.1.0
diff --git a/etc/requirements.in b/etc/requirements.in
new file mode 100644
index 0000000000..a4e6eba9b3
--- /dev/null
+++ b/etc/requirements.in
@@ -0,0 +1,63 @@
+# Incompatible with earlier PIP versions
+pip>=7.1.0
+# bcolz fails to install if this is not in the build_requires.
+setuptools>18.0
+
+Logbook>=0.12.5
+
+# Command line interface helper
+click>=4.0.0
+
+# Language utilities
+six>=1.10.0
+contextlib2>=0.4.0
+python-interface>=1.5.3
+multipledispatch>=0.6.0
+# FUNctional programming utilities
+toolz>=0.8.2
+
+# Scientific Libraries
+numpy>=1.11.3
+pandas>=0.18.1,<=0.22
+pandas-datareader>=0.2.1
+scipy>=0.17.1
+# Needed for parts of pandas.stats
+patsy>=0.4.0
+statsmodels>=0.6.1
+
+# For financial risk calculations
+empyrical>=0.5.0
+
+# Dates/times/calendars
+pytz>=2018.5
+# Country Codes
+iso3166>=0.9
+trading-calendars>=1.6.1
+
+# For fetching remote data
+requests>=2.9.1
+
+# Asset writer and finder
+sqlalchemy>=1.0.8
+# For asset db management
+alembic>=0.7.7
+
+# On disk storage format for pipeline data.
+bcolz>=0.12.1,<1
+# On disk storage format for pricing data.
+h5py>=2.7.1
+tables>=3.4.3
+
+# Performance
+lru-dict>=1.1.4
+intervaltree>=2.1.0
+# faster array ops.
+bottleneck>=1.0.0
+
+# Graph algorithms used by zipline.pipeline
+networkx>=1.9.1,<2.0
+# NumericalExpression pipeline terms.
+numexpr>=2.6.1
+
+# Currency Codes
+iso4217>=1.6.20180829
diff --git a/etc/requirements.txt b/etc/requirements.txt
index 641bad6263..f8524ca371 100644
--- a/etc/requirements.txt
+++ b/etc/requirements.txt
@@ -1,102 +1,107 @@
-# Incompatible with earlier PIP versions
-pip>=7.1.0
-# XXX: bcolz fails to install if this is not in the build_requires.
-setuptools>18.0
-
-# Logging
-Logbook==0.12.5
-
-# Scientific Libraries
-
-pytz==2018.5
-numpy==1.11.3
-
-# for pandas-datareader
-requests-file==1.4.1
-
-# for requests
-certifi==2018.8.24
-chardet==3.0.4
-idna==2.7
-urllib3==1.23
-
-# scipy and pandas are required for statsmodels,
-# statsmodels in turn is required for some pandas packages
-scipy==0.17.1
-pandas==0.18.1
-pandas-datareader==0.2.1
-# Needed for parts of pandas.stats
-patsy==0.4.0
-statsmodels==0.6.1
-
-python-dateutil==2.4.2
-six==1.11.0
-
-# For fetching remote data
-requests==2.20.1
-
-Cython==0.25.2
-
-# faster OrderedDict
-cyordereddict==0.2.2
-
-# faster array ops.
+#
+# This file is autogenerated by pip-compile
+# To update, run:
+#
+#    pip-compile --no-index --output-file=etc/requirements.txt etc/requirements.in etc/requirements_blaze.in etc/requirements_build.in etc/requirements_dev.in etc/requirements_docs.in etc/requirements_talib.in
+#
+-e git+git://github.com/quantopian/blaze.git@f26375a6708eab85b7acc7869d6c518df2f974eb#egg=blaze
+-e git+git://github.com/quantopian/datashape.git@cae16a85406ca4302ff1f985b74a3809be0a83a1#egg=datashape
+-e git+git://github.com/quantopian/odo.git@ba84238eb8dbcac4784ae7ebf62988d7e163c283#egg=odo
+alabaster==0.7.12         # via sphinx
+alembic==0.7.7
+argh==0.26.2              # via sphinx-autobuild, watchdog
+babel==2.6.0              # via sphinx
+backports-abc==0.5        # via tornado
+bcolz==0.12.1
 bottleneck==1.0.0
-
+certifi==2018.8.24        # via requests
+chardet==3.0.4            # via requests
+click==7.0.0
+cloudpickle==0.2.1        # via dask
+configparser==3.5.0       # via flake8
 contextlib2==0.4.0
-
-# networkx requires decorator
-decorator==4.0.0
-
-# Graph algorithms used by zipline.pipeline
-networkx==1.9.1
-
-# NumericalExpression pipeline terms.
-numexpr==2.6.1
-
-# On disk storage format for pipeline data.
-bcolz==0.12.1
-
-# On disk storage format for pricing data.
+cookies==2.2.1            # via responses
+coverage==4.0.3
+cycler==0.10.0            # via matplotlib
+cython==0.25.2
+cytoolz==0.8.2
+dask[dataframe]==0.13.0
+decorator==4.0.0          # via networkx
+docutils==0.14            # via sphinx
+empyrical==0.5.0
+enum34==1.1.6             # via flake8
+flake8==3.6.0
+flask-cors==2.1.3
+flask==1.1.1              # via flask-cors
+funcsigs==1.0.2           # via mock, python-interface
+futures==3.2.0            # via tornado
 h5py==2.7.1
-
-# Command line interface helper
-click==4.0.0
-
-# FUNctional programming utilities
-toolz==0.8.2
-multipledispatch==0.6.0
-
-# for alembic
-MarkupSafe==0.23
-Mako==1.0.1
-# Asset writer and finder
-sqlalchemy==1.1.18
-# For asset db management
-alembic==0.7.7
-
-sortedcontainers==1.4.4
-# for intervaltree
+idna==2.7                 # via requests
 intervaltree==2.1.0
-
-# for caching
+iso3166==0.9
+iso4217==1.6.20180829
+itsdangerous==0.24        # via flask
+jinja2==2.10.1            # via flask, sphinx
+livereload==2.6.0         # via sphinx-autobuild
+locket==0.2.0             # via partd
+logbook==0.12.5
 lru-dict==1.1.4
-
-# For financial risk calculations
-empyrical==0.5.0
-
+mako==1.0.1               # via alembic
+markupsafe==0.23          # via jinja2, mako
+matplotlib==1.5.3
+mccabe==0.6.0             # via flake8
+mock==2.0.0
+multipledispatch==0.6.0
+networkx==1.9.1
+nose-ignore-docstring==0.2
+nose-parameterized==0.5.0
+nose-timer==0.5.0
+nose==1.3.7
+numexpr==2.6.1
+numpy==1.11.3
+numpydoc==0.5.0
+pandas-datareader==0.2.1
+pandas==0.18.1
+partd==0.3.7              # via dask
+pathtools==0.1.2          # via sphinx-autobuild, watchdog
+patsy==0.4.0
+pbr==4.3.0                # via mock
+pip-tools==4.3.0
+port-for==0.3.1           # via sphinx-autobuild
+psutil==4.3.0
+pycodestyle==2.4.0        # via flake8
+pyflakes==2.0.0           # via flake8
+pygments==2.2.0           # via sphinx
+pyparsing==2.0.3          # via matplotlib
+python-dateutil==2.4.2    # via matplotlib, pandas
+python-interface==1.5.3
+pytz==2018.5
+pyyaml==3.13              # via sphinx-autobuild, watchdog
+requests-file==1.4.1      # via pandas-datareader
+requests==2.20.1
+responses==0.9.0
+scipy==0.17.1
+singledispatch==3.4.0.3   # via tornado
+six==1.11.0
+snowballstemmer==1.2.1    # via sphinx
+sortedcontainers==1.4.4   # via intervaltree
+sphinx-autobuild==0.6.0
+sphinx-rtd-theme==0.4.2   # via sphinx
+sphinx==1.3.2
+sqlalchemy==1.3.11
+statsmodels==0.6.1
+ta-lib==0.4.9
 tables==3.4.3
-
-# For trading calendars
+termcolor==1.1.0          # via nose-timer
+testfixtures==6.10.1
+toolz==0.8.2
+tornado==5.1.1            # via livereload, sphinx-autobuild
 trading-calendars==1.11.2
-
-# Interface definitions.
-python-interface==1.5.3
-funcsigs==1.0.2
-typing==3.6.2
-
-# Country Codes
-iso3166==0.9
-
-# Currency Codes
-iso4217==1.6.20180829
+typing==3.6.2             # via python-interface
+urllib3==1.24.3           # via requests
+watchdog==0.9.0           # via sphinx-autobuild
+werkzeug==0.16.0          # via flask
+
+# The following packages are considered to be unsafe in a requirements file:
+# pip
+# setuptools
diff --git a/etc/requirements_blaze.txt b/etc/requirements_blaze.in
similarity index 59%
rename from etc/requirements_blaze.txt
rename to etc/requirements_blaze.in
index a03a5c9457..83ba3d141c 100644
--- a/etc/requirements_blaze.txt
+++ b/etc/requirements_blaze.in
@@ -1,20 +1,7 @@
+-e git://github.com/quantopian/blaze.git@f26375a6708eab85b7acc7869d6c518df2f974eb#egg=blaze
+dask[dataframe]>=0.13.0
 -e git://github.com/quantopian/datashape.git@cae16a85406ca4302ff1f985b74a3809be0a83a1#egg=datashape
 -e git://github.com/quantopian/odo.git@ba84238eb8dbcac4784ae7ebf62988d7e163c283#egg=odo
 
 # Keep cytoolz version in sync with toolz version in requirements.txt
-cytoolz==0.8.2
-
-# Transitive dependencies of blaze:
-dask[dataframe]==0.13.0
-partd==0.3.7
-locket==0.2.0
-cloudpickle==0.2.1
-itsdangerous==0.24
-flask==0.12.4
-flask-cors==2.1.3
-Jinja2==2.10.1
-MarkupSafe==0.23
-Werkzeug==0.12.2
-psutil==4.3.0
-
--e git://github.com/quantopian/blaze.git@f26375a6708eab85b7acc7869d6c518df2f974eb#egg=blaze
+cytoolz>=0.8.2
diff --git a/etc/requirements_build.in b/etc/requirements_build.in
new file mode 100644
index 0000000000..3e59e8f41b
--- /dev/null
+++ b/etc/requirements_build.in
@@ -0,0 +1,2 @@
+Cython>=0.25.2
+numpy>=1.11.3
diff --git a/etc/requirements_dev.in b/etc/requirements_dev.in
new file mode 100644
index 0000000000..3950c0ac67
--- /dev/null
+++ b/etc/requirements_dev.in
@@ -0,0 +1,23 @@
+# Testing
+coverage>=4.0.3
+nose>=1.3.7
+nose-parameterized>=0.5.0
+nose-ignore-docstring>=0.2
+nose-timer>=0.5.0
+
+mock>=2.0.0
+
+# Temp Directories for testing
+testfixtures>=4.1.2
+
+# Linting
+flake8>=3.3.0
+
+# Algo examples
+matplotlib>=1.5.3
+
+# For mocking out requests fetches
+responses>=0.9.0
+
+# Compilation of pinned requirements
+pip-tools>=4.3.0
diff --git a/etc/requirements_dev.txt b/etc/requirements_dev.txt
deleted file mode 100644
index 48a2ca1554..0000000000
--- a/etc/requirements_dev.txt
+++ /dev/null
@@ -1,62 +0,0 @@
-# Testing
-coverage==4.0.3
-nose==1.3.7
-nose-parameterized==0.5.0
-nose-ignore-docstring==0.2
-termcolor==1.1.0
-nose-timer==0.5.0
-xlrd==0.9.4
-
-# These are required by mock or its dependencies
-Jinja2==2.10.1
-funcsigs==1.0.2
-Pygments==2.2.0
-alabaster==0.7.6
-babel==1.3
-docutils==0.12
-snowballstemmer==1.2.0
-sphinx-rtd-theme==0.1.8
-sphinx==1.3.4
-pbr==1.10.0
-
-mock==2.0.0
-
-# Temp Directories for testing
-testfixtures==6.10.1
-
-# Linting
-
-flake8==3.6.0
-mccabe==0.6.0
-pycodestyle==2.4.0
-pyflakes==2.0.0
-configparser==3.5.0;python_version<"3.2"
-
-# Documentation Conversion
-
-pyandoc==0.0.1
-docopt==0.6.2
-numpydoc==0.5
-mistune==0.8.4
-
-# Example scripts that are run during unit tests use the following:
-
-# matplotlib dependencies:
-pyparsing==2.0.3
-cycler==0.10.0
-matplotlib==1.5.3
-
-Markdown==2.6.2
-
-# Checking for old PIP packages
-futures==3.0.5;python_version<'3.0'
-requests-futures==0.9.7
-piprot==0.9.6
-
-# For mocking out requests fetches
-responses==0.9.0
-
-# Note: pdbpp is frequently very useful for development and debugging;
-# but not everyone likes it, and it applies nightmare-inducing sys.path
-# hacks during the site-packages discovery process, so it is no longer
-# included as a requirement. Install and use at your own risk.
diff --git a/etc/requirements_docs.txt b/etc/requirements_docs.in
similarity index 55%
rename from etc/requirements_docs.txt
rename to etc/requirements_docs.in
index 362d47254a..40a2573c95 100644
--- a/etc/requirements_docs.txt
+++ b/etc/requirements_docs.in
@@ -1,3 +1,3 @@
 Sphinx>=1.3.2
 numpydoc>=0.5.0
-sphinx-autobuild==0.6.0
+sphinx-autobuild>=0.6.0
diff --git a/etc/requirements_talib.in b/etc/requirements_talib.in
new file mode 100644
index 0000000000..9bd5ec819a
--- /dev/null
+++ b/etc/requirements_talib.in
@@ -0,0 +1 @@
+TA-Lib>=0.4.9
diff --git a/etc/requirements_talib.txt b/etc/requirements_talib.txt
deleted file mode 100644
index 478a392bb2..0000000000
--- a/etc/requirements_talib.txt
+++ /dev/null
@@ -1 +0,0 @@
-TA-Lib==0.4.9
diff --git a/setup.py b/setup.py
index c21b0855bb..a0ef29551c 100644
--- a/setup.py
+++ b/setup.py
@@ -165,25 +165,6 @@ def _filter_requirements(lines_iter, filter_names=None,
         yield line
 
 
-REQ_UPPER_BOUNDS = {
-    'bcolz': '<1',
-    'pandas': '<=0.22',
-    'networkx': '<2.0',
-}
-
-
-def _with_bounds(req):
-    try:
-        req, lower = req.split('==')
-    except ValueError:
-        return req
-    else:
-        with_bounds = [req, '>=', lower]
-        upper = REQ_UPPER_BOUNDS.get(req)
-        if upper:
-            with_bounds.extend([',', upper])
-        return ''.join(with_bounds)
-
 
 REQ_PATTERN = re.compile(
     r"(?P<name>[^=<>]+)(?P<comp>[<=>]{1,2})(?P<spec>[^;]+)"
@@ -215,39 +196,29 @@ def _sub(m):
 
 
 def read_requirements(path,
-                      strict_bounds,
                       conda_format=False,
                       filter_names=None):
     """
     Read a requirements.txt file, expressed as a path relative to Zipline root.
-
-    Returns requirements with the pinned versions as lower bounds
-    if `strict_bounds` is falsey.
     """
     real_path = join(dirname(abspath(__file__)), path)
     with open(real_path) as f:
         reqs = _filter_requirements(f.readlines(), filter_names=filter_names,
                                     filter_sys_version=not conda_format)
 
-        if not strict_bounds:
-            reqs = map(_with_bounds, reqs)
-
         if conda_format:
             reqs = map(_conda_format, reqs)
 
         return list(reqs)
 
 
-def install_requires(strict_bounds=False, conda_format=False):
-    return read_requirements('etc/requirements.txt',
-                             strict_bounds=strict_bounds,
-                             conda_format=conda_format)
+def install_requires(conda_format=False):
+    return read_requirements('etc/requirements.in', conda_format=conda_format)
 
 
 def extras_requires(conda_format=False):
     extras = {
-        extra: read_requirements('etc/requirements_{0}.txt'.format(extra),
-                                 strict_bounds=True,
+        extra: read_requirements('etc/requirements_{0}.in'.format(extra),
                                  conda_format=conda_format)
         for extra in ('dev', 'talib')
     }
@@ -256,11 +227,10 @@ def extras_requires(conda_format=False):
     return extras
 
 
-def setup_requirements(requirements_path, module_names, strict_bounds,
+def setup_requirements(requirements_path, module_names,
                        conda_format=False):
     module_names = set(module_names)
     module_lines = read_requirements(requirements_path,
-                                     strict_bounds=strict_bounds,
                                      conda_format=conda_format,
                                      filter_names=module_names)
 
@@ -276,9 +246,8 @@ def setup_requirements(requirements_path, module_names, strict_bounds,
                                                 'conda-build-script.py')  # win
 
 setup_requires = setup_requirements(
-    'etc/requirements.txt',
+    'etc/requirements_build.in',
     ('Cython', 'numpy'),
-    strict_bounds=conda_build,
     conda_format=conda_build,
 )