diff --git a/cirq-core/cirq/__init__.py b/cirq-core/cirq/__init__.py
index a82f106526d..3aeace7669d 100644
--- a/cirq-core/cirq/__init__.py
+++ b/cirq-core/cirq/__init__.py
@@ -83,6 +83,7 @@
     ConstantQubitNoiseModel,
     Device,
     DeviceMetadata,
+    GateDurationTable,
     GridDeviceMetadata,
     GridQid,
     GridQubit,
diff --git a/cirq-core/cirq/devices/__init__.py b/cirq-core/cirq/devices/__init__.py
index 7ff622946a1..f16b22e4b3f 100644
--- a/cirq-core/cirq/devices/__init__.py
+++ b/cirq-core/cirq/devices/__init__.py
@@ -16,7 +16,7 @@
 
 from cirq.devices.device import Device, DeviceMetadata
 
-from cirq.devices.grid_device_metadata import GridDeviceMetadata
+from cirq.devices.grid_device_metadata import GateDurationTable, GridDeviceMetadata
 
 from cirq.devices.grid_qubit import GridQid, GridQubit
 
diff --git a/cirq-core/cirq/devices/grid_device_metadata.py b/cirq-core/cirq/devices/grid_device_metadata.py
index 00da05e27a9..7a64bd9f4c8 100644
--- a/cirq-core/cirq/devices/grid_device_metadata.py
+++ b/cirq-core/cirq/devices/grid_device_metadata.py
@@ -13,7 +13,7 @@
 # limitations under the License.
 """Metadata subtype for 2D Homogenous devices."""
 
-from typing import TYPE_CHECKING, Optional, FrozenSet, Iterable, Tuple, Dict
+from typing import TYPE_CHECKING, Optional, FrozenSet, Iterable, Tuple, Dict, Union, Type
 
 import networkx as nx
 from cirq import value
@@ -23,6 +23,48 @@
     import cirq
 
 
+class GateDurationTable:
+    """A lookup table for gate durations.
+
+    This class allows different instances of a `cirq.GateFamily` to be used as a key for duration
+    lookup, as opposed to using the GateFamily as the key in a simple dictionary format.
+
+    For example:
+        >>> gdt = cirq.GateDurationTable({
+                cirq.GateFamily(cirq.XPowGate): cirq.Duration(nanos=1),
+            })
+        >>> gdt[cirq.X]         # Prints `cirq.Duration(nanos=1)`
+        >>> gdt[cirq.X**0.25]   # Prints `cirq.Duration(nanos=1)`
+    """
+
+    def __init__(self, gate_durations: Dict['cirq.GateFamily', 'cirq.Duration']) -> None:
+        self.gate_durations = gate_durations
+
+    def __getitem__(
+        self, gate: Union['cirq.Gate', Type['cirq.Gate'], 'cirq.GateFamily']
+    ) -> 'cirq.Duration':
+
+        found_duration = None
+
+        for gf, duration in self.gate_durations.items():
+            if gate in gf or gate == gf:
+                if found_duration is not None:
+                    # TODO(verult) Include overlapping gatefamilies in error message
+                    raise RuntimeError(
+                        "The given gate matches multiple durations. This may be due to an overlap"
+                        " of GateFamilies provided by the device."
+                    )
+                found_duration = duration
+
+        if found_duration is None:
+            raise KeyError("Gate not found in gate duration table.")
+
+        return found_duration
+
+    def __str__(self):
+        return str(self.gate_durations)
+
+
 @value.value_equality
 class GridDeviceMetadata(device.DeviceMetadata):
     """Hardware metadata for homogenous 2d symmetric grid devices."""
@@ -110,8 +152,9 @@ def __init__(
                     f" gate_durations={gate_durations}"
                     f" gateset.gates={gateset.gates}"
                 )
-
-        self._gate_durations = gate_durations
+            self._gate_durations = GateDurationTable(gate_durations)
+        else:
+            self._gate_durations = None
 
     @property
     def qubit_pairs(self) -> FrozenSet[FrozenSet['cirq.Qid']]:
@@ -138,7 +181,7 @@ def compilation_target_gatesets(self) -> Tuple['cirq.CompilationTargetGateset',
         return self._compilation_target_gatesets
 
     @property
-    def gate_durations(self) -> Optional[Dict['cirq.GateFamily', 'cirq.Duration']]:
+    def gate_durations(self) -> Optional[GateDurationTable]:
         """Get a dictionary mapping from gateset to duration for gates."""
         return self._gate_durations