diff --git a/extensions/quartz/deployment/src/test/java/io/quarkus/quartz/test/DependentBeanJobTest.java b/extensions/quartz/deployment/src/test/java/io/quarkus/quartz/test/DependentBeanJobTest.java
new file mode 100644
index 0000000000000..cd6d828a1a1c9
--- /dev/null
+++ b/extensions/quartz/deployment/src/test/java/io/quarkus/quartz/test/DependentBeanJobTest.java
@@ -0,0 +1,126 @@
+package io.quarkus.quartz.test;
+
+import static org.junit.jupiter.api.Assertions.assertEquals;
+import static org.junit.jupiter.api.Assertions.assertTrue;
+
+import java.util.concurrent.CountDownLatch;
+import java.util.concurrent.TimeUnit;
+
+import jakarta.annotation.PostConstruct;
+import jakarta.annotation.PreDestroy;
+import jakarta.enterprise.context.ApplicationScoped;
+import jakarta.enterprise.context.Dependent;
+import jakarta.inject.Inject;
+
+import org.jboss.shrinkwrap.api.asset.StringAsset;
+import org.junit.jupiter.api.Test;
+import org.junit.jupiter.api.extension.RegisterExtension;
+import org.quartz.Job;
+import org.quartz.JobBuilder;
+import org.quartz.JobDetail;
+import org.quartz.JobExecutionContext;
+import org.quartz.JobExecutionException;
+import org.quartz.Scheduler;
+import org.quartz.SchedulerException;
+import org.quartz.SimpleScheduleBuilder;
+import org.quartz.Trigger;
+import org.quartz.TriggerBuilder;
+
+import io.quarkus.test.QuarkusUnitTest;
+
+public class DependentBeanJobTest {
+
+    @RegisterExtension
+    static final QuarkusUnitTest test = new QuarkusUnitTest()
+            .withApplicationRoot((jar) -> jar
+                    .addClasses(Service.class, MyJob.class)
+                    .addAsResource(new StringAsset("quarkus.quartz.start-mode=forced"),
+                            "application.properties"));
+
+    @Inject
+    Scheduler quartz;
+
+    @Inject
+    Service service;
+
+    @Test
+    public void testDependentBeanJobDestroyed() throws SchedulerException, InterruptedException {
+        assertEquals(0, MyJob.timesConstructed);
+        assertEquals(0, MyJob.timesDestroyed);
+        // prepare latch, schedule 10 one-off jobs, assert
+        CountDownLatch latch = service.initializeLatch(10);
+        for (int i = 0; i < 10; i++) {
+            Trigger trigger = TriggerBuilder.newTrigger()
+                    .withIdentity("myTrigger" + i, "myGroup")
+                    .startNow()
+                    .build();
+            JobDetail job = JobBuilder.newJob(MyJob.class)
+                    .withIdentity("myJob" + i, "myGroup")
+                    .build();
+            quartz.scheduleJob(job, trigger);
+        }
+        assertTrue(latch.await(5, TimeUnit.SECONDS), "Latch count: " + latch.getCount());
+        assertEquals(10, MyJob.timesConstructed);
+        assertEquals(10, MyJob.timesDestroyed);
+
+        // now try the same with repeating job triggering three times
+        latch = service.initializeLatch(3);
+        JobDetail job = JobBuilder.newJob(MyJob.class)
+                .withIdentity("myRepeatingJob", "myGroup")
+                .build();
+        Trigger trigger = TriggerBuilder.newTrigger()
+                .withIdentity("myRepeatingTrigger", "myGroup")
+                .startNow()
+                .withSchedule(
+                        SimpleScheduleBuilder.simpleSchedule()
+                                .withIntervalInMilliseconds(333)
+                                .withRepeatCount(3))
+                .build();
+        quartz.scheduleJob(job, trigger);
+
+        assertTrue(latch.await(2, TimeUnit.SECONDS), "Latch count: " + latch.getCount());
+        assertEquals(13, MyJob.timesConstructed);
+        assertEquals(13, MyJob.timesDestroyed);
+    }
+
+    @ApplicationScoped
+    public static class Service {
+
+        volatile CountDownLatch latch;
+
+        public CountDownLatch initializeLatch(int latchCountdown) {
+            this.latch = new CountDownLatch(latchCountdown);
+            return latch;
+        }
+
+        public void execute() {
+            latch.countDown();
+        }
+
+    }
+
+    @Dependent
+    static class MyJob implements Job {
+
+        public static volatile int timesConstructed = 0;
+        public static volatile int timesDestroyed = 0;
+
+        @Inject
+        Service service;
+
+        @PostConstruct
+        void postConstruct() {
+            timesConstructed++;
+        }
+
+        @PreDestroy
+        void preDestroy() {
+            timesDestroyed++;
+        }
+
+        @Override
+        public void execute(JobExecutionContext context) throws JobExecutionException {
+            service.execute();
+        }
+    }
+}
diff --git a/extensions/quartz/runtime/src/main/java/io/quarkus/quartz/runtime/CdiAwareJob.java b/extensions/quartz/runtime/src/main/java/io/quarkus/quartz/runtime/CdiAwareJob.java
new file mode 100644
index 0000000000000..2618bb4379878
--- /dev/null
+++ b/extensions/quartz/runtime/src/main/java/io/quarkus/quartz/runtime/CdiAwareJob.java
@@ -0,0 +1,36 @@
+package io.quarkus.quartz.runtime;
+
+import jakarta.enterprise.context.Dependent;
+import jakarta.enterprise.inject.Instance;
+
+import org.quartz.Job;
+import org.quartz.JobExecutionContext;
+import org.quartz.JobExecutionException;
+import org.quartz.Scheduler;
+import org.quartz.spi.TriggerFiredBundle;
+
+/**
+ * An abstraction allowing proper destruction of Job instances in case they are dependent beans.
+ * According to {@link org.quartz.spi.JobFactory#newJob(TriggerFiredBundle, Scheduler)}, a new job instance is created for every
+ * trigger.
+ * We will therefore create a new dependent bean for every trigger and destroy it afterwards.
+ */
+class CdiAwareJob implements Job {
+
+    private final Instance.Handle<? extends Job> jobInstanceHandle;
+
+    public CdiAwareJob(Instance.Handle<? extends Job> jobInstanceHandle) {
+        this.jobInstanceHandle = jobInstanceHandle;
+    }
+
+    @Override
+    public void execute(JobExecutionContext context) throws JobExecutionException {
+        try {
+            jobInstanceHandle.get().execute(context);
+        } finally {
+            if (jobInstanceHandle.getBean().getScope().equals(Dependent.class)) {
+                jobInstanceHandle.destroy();
+            }
+        }
+    }
+}
diff --git a/extensions/quartz/runtime/src/main/java/io/quarkus/quartz/runtime/QuartzSchedulerImpl.java b/extensions/quartz/runtime/src/main/java/io/quarkus/quartz/runtime/QuartzSchedulerImpl.java
index 60e76ea042e8e..e2b9638cd387a 100644
--- a/extensions/quartz/runtime/src/main/java/io/quarkus/quartz/runtime/QuartzSchedulerImpl.java
+++ b/extensions/quartz/runtime/src/main/java/io/quarkus/quartz/runtime/QuartzSchedulerImpl.java
@@ -1243,10 +1243,10 @@ public Job newJob(TriggerFiredBundle bundle, org.quartz.Scheduler Scheduler) thr
                 // Get the original class from an intercepted bean class
                 jobClass = (Class<? extends Job>) jobClass.getSuperclass();
             }
-            Instance<?> instance = jobs.select(jobClass);
+            Instance<? extends Job> instance = jobs.select(jobClass);
             if (instance.isResolvable()) {
                 // This is a job backed by a CDI bean
-                return jobWithSpanWrapper((Job) instance.get());
+                return jobWithSpanWrapper(new CdiAwareJob(instance.getHandle()));
             }
             // Instantiate a plain job class
             return jobWithSpanWrapper(super.newJob(bundle, Scheduler));