diff --git a/.github/workflows/CI.yaml b/.github/workflows/CI.yaml
index 8f4944b5b1..f7e5b52630 100644
--- a/.github/workflows/CI.yaml
+++ b/.github/workflows/CI.yaml
@@ -176,6 +176,11 @@ jobs:
 #       DOCKER_BUILDKIT: 1
 #      run: docker build --platform=linux/arm64 .
 
+    - name: Docker Build (linux/ppc64le)
+      env:
+       DOCKER_BUILDKIT: 1
+      run: docker build --platform=linux/ppc64le .
+
   mysql:
     name: E2E MySQL Test
     runs-on: ubuntu-latest
diff --git a/.github/workflows/build-and-publish.yaml b/.github/workflows/build-and-publish.yaml
index 3154a9b7e5..5fef976e1d 100644
--- a/.github/workflows/build-and-publish.yaml
+++ b/.github/workflows/build-and-publish.yaml
@@ -31,6 +31,12 @@ jobs:
           BRANCH_NAME=${GITHUB_REF#refs/heads/}
           echo "::set-output name=version::${BRANCH_NAME/${{ env.BRANCH_PREFIX }}/}"
 
+      - name: Set up QEMU
+        uses: docker/setup-qemu-action@v2
+
+      - name: Set up Docker Buildx
+        uses: docker/setup-buildx-action@v2
+
       - name: Login to Quay.io
         uses: docker/login-action@v1
         with:
@@ -44,6 +50,7 @@ jobs:
         env:
           TAG: ${{ steps.version-from-branch.outputs.version }}${{ env.TAG_SUFFIX }}
         with:
+          platforms: linux/amd64,linux/ppc64le
           push: true
           tags: ${{ env.REGISTRY }}/${{ env.REPO_NAME }}:${{ github.event.inputs.tag || env.TAG }}
 
diff --git a/Dockerfile b/Dockerfile
index 2ffdc1ad7c..633b6f8b48 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -50,13 +50,30 @@ RUN set -ex\
 		openldap-devel\
 		python39-devel\
 		libffi-devel\
+        openssl-devel \
+        diffutils \
+        file \
+        make \
+        libjpeg-turbo \
+        libjpeg-turbo-devel \
+		wget\
 	; dnf -y -q clean all
 WORKDIR /build
 COPY requirements.txt .
 # Note that it installs into PYTHONUSERBASE because of the '--user'
 # flag.
+RUN ARCH=$(uname -m) ; echo $ARCH; \
+    if [ "$ARCH" == "ppc64le" ] ; then \
+    GE_LATEST=$(grep "gevent" requirements.txt |cut -d "=" -f 3); \
+	wget https://github.com/IBM/oss-ecosystem-gevent/releases/download/${GE_LATEST}/manylinux_ppc64le_wheels_${GE_LATEST}.tar.gz; \
+	tar xvf manylinux_ppc64le_wheels_${GE_LATEST}.tar.gz; \
+	python3 -m pip install --no-cache-dir --user wheelhouse/gevent-${GE_LATEST}-cp39-cp39-manylinux_2_17_ppc64le.manylinux2014_ppc64le.whl; \
+    GRPC_LATEST=$(grep "grpcio" requirements.txt |cut -d "=" -f 3); \
+	wget https://github.com/IBM/oss-ecosystem-grpc/releases/download/${GRPC_LATEST}/grpcio-${GRPC_LATEST}-cp39-cp39-linux_ppc64le.whl; \
+	python3 -m pip install --no-cache-dir --user grpcio-${GRPC_LATEST}-cp39-cp39-linux_ppc64le.whl; \
+	fi
 RUN set -ex\
-	; python3 -m pip install --no-cache-dir --progress-bar off --user $(grep -e '^pip=' -e '^wheel=' ./requirements.txt) \
+    ; python3 -m pip install --no-cache-dir --progress-bar off --user $(grep -e '^pip=' -e '^wheel=' -e '^setuptools=' ./requirements.txt) \
 	; python3 -m pip install --no-cache-dir --progress-bar off --user --requirement requirements.txt \
 	;
 RUN set -ex\
@@ -94,9 +111,11 @@ RUN chown -R 1001:0 quay-ui/dist
 
 # Pushgateway grabs pushgateway.
 FROM registry.access.redhat.com/ubi8/ubi:latest AS pushgateway
-ENV OS=linux ARCH=amd64
+ENV OS=linux 
 ARG PUSHGATEWAY_VERSION=1.0.0
 RUN set -ex\
+	; ARCH=$(uname -m) ; echo $ARCH \
+	; if [ "$ARCH" == "x86_64" ] ; then ARCH="amd64" ; elif [ "$ARCH" == "arm_64" ] ; then ARCH="arm64" ; fi \
 	; curl -fsSL "https://github.com/prometheus/pushgateway/releases/download/v${PUSHGATEWAY_VERSION}/pushgateway-${PUSHGATEWAY_VERSION}.${OS}-${ARCH}.tar.gz"\
 	| tar xz "pushgateway-${PUSHGATEWAY_VERSION}.${OS}-${ARCH}/pushgateway"\
 	; install "pushgateway-${PUSHGATEWAY_VERSION}.${OS}-${ARCH}/pushgateway" /usr/local/bin/pushgateway\
diff --git a/requirements.txt b/requirements.txt
index a253c31737..0a50d94bb7 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -147,8 +147,8 @@ Cython==3.0.0a9
 flit_core==3.7.1
 toml==0.10.2
 jsonpickle==1.2
-pip==21.3
-setuptools==50.3.0
+pip==22.2.1
+setuptools==63.4.0
 setuptools-scm[toml]==4.1.2
 typing_extensions==4.0.1
 wheel==0.35.1