diff --git a/ravendb/documents/session/operations/stream.py b/ravendb/documents/session/operations/stream.py
index 1220025d..d1b2bff2 100644
--- a/ravendb/documents/session/operations/stream.py
+++ b/ravendb/documents/session/operations/stream.py
@@ -65,7 +65,7 @@ def create_request(self, query: IndexQuery) -> QueryStreamCommand:
     #     return StreamCommand("".join(sb))
 
     def set_result(self, response: StreamResultResponse) -> Iterator[Dict]:
-        if response.stream_iterator is None:
+        if response is None or response.stream_iterator is None:
             raise IndexDoesNotExistException("The index does not exists, failed to stream results")
 
         parser = JSONLRavenStreamParser(response.stream_iterator)
diff --git a/ravendb/tests/jvm_migrated_tests/issues_tests/test_ravenDB_16321.py b/ravendb/tests/jvm_migrated_tests/issues_tests/test_ravenDB_16321.py
new file mode 100644
index 00000000..61e39dba
--- /dev/null
+++ b/ravendb/tests/jvm_migrated_tests/issues_tests/test_ravenDB_16321.py
@@ -0,0 +1,16 @@
+from ravendb.documents.queries.misc import Query
+from ravendb.exceptions.exceptions import IndexDoesNotExistException
+from ravendb.tests.test_base import TestBase
+
+
+class TestRavenDB16321(TestBase):
+    def setUp(self):
+        super(TestRavenDB16321, self).setUp()
+
+    def test_streaming_on_index_that_does_not_exist_should_throw(self):
+        with self.store.open_session() as session:
+            query = session.query(Query.from_index_name("idkb2")).where_equals("Natalia", "first_name")
+
+            with self.assertRaises(IndexDoesNotExistException):
+                stream = session.advanced.stream(query)
+                stream.__next__()