diff --git a/packages/realm-react/CHANGELOG.md b/packages/realm-react/CHANGELOG.md
index c38729fb52..8c09c91d08 100644
--- a/packages/realm-react/CHANGELOG.md
+++ b/packages/realm-react/CHANGELOG.md
@@ -1,3 +1,17 @@
+x.x.x Release notes (yyyy-MM-dd)
+=============================================================
+### Enhancements
+* None.
+
+### Fixed
+* Fixed potential "Cannot create asynchronous query while in a write transaction" error with `useObject` due to adding event listeners while in a write transaction ([#4375](https://github.com/realm/realm-js/issues/4375), since v0.1.0)
+
+### Compatibility
+* None.
+
+### Internal
+* None.
+
 0.2.1 Release notes (2022-03-24)
 =============================================================
 ### Enhancements
diff --git a/packages/realm-react/src/__tests__/useObjectRender.test.tsx b/packages/realm-react/src/__tests__/useObjectRender.test.tsx
index a88473d0d4..e115096e36 100644
--- a/packages/realm-react/src/__tests__/useObjectRender.test.tsx
+++ b/packages/realm-react/src/__tests__/useObjectRender.test.tsx
@@ -283,6 +283,7 @@ describe("useObject: rendering objects with a Realm.List property", () => {
         testRealm.write(() => {
           object.favoriteItem = object.items[0];
         });
+        forceSynchronousNotifications(testRealm);
       });
 
       expect(getByTestId(`favoriteItem-${object.items[0].name}`)).toBeTruthy();
@@ -291,6 +292,7 @@ describe("useObject: rendering objects with a Realm.List property", () => {
         testRealm.write(() => {
           object.favoriteItem = object.items[1];
         });
+        forceSynchronousNotifications(testRealm);
       });
 
       expect(getByTestId(`favoriteItem-${object.items[1].name}`)).toBeTruthy();
@@ -299,6 +301,7 @@ describe("useObject: rendering objects with a Realm.List property", () => {
         testRealm.write(() => {
           object.items[1].name = "apple";
         });
+        forceSynchronousNotifications(testRealm);
       });
 
       expect(getByTestId(`favoriteItem-${object.items[1].name}`)).toBeTruthy();
diff --git a/packages/realm-react/src/__tests__/useQueryHook.test.tsx b/packages/realm-react/src/__tests__/useQueryHook.test.tsx
index 339275bc5d..4789a7d7b9 100644
--- a/packages/realm-react/src/__tests__/useQueryHook.test.tsx
+++ b/packages/realm-react/src/__tests__/useQueryHook.test.tsx
@@ -78,9 +78,11 @@ describe("useQueryHook", () => {
     });
     realm.close();
   });
+
   afterEach(() => {
     Realm.clearTestState();
   });
+
   it("can retrieve collections using useQuery", () => {
     const { result } = renderHook(() => useQuery<IDog>("dog"));
     const collection = result.current;
diff --git a/packages/realm-react/src/__tests__/useQueryRender.test.tsx b/packages/realm-react/src/__tests__/useQueryRender.test.tsx
index aa5bb47bb2..b47f3b3e50 100644
--- a/packages/realm-react/src/__tests__/useQueryRender.test.tsx
+++ b/packages/realm-react/src/__tests__/useQueryRender.test.tsx
@@ -75,7 +75,7 @@ const tagRenderCounter = jest.fn();
 
 let testRealm: Realm = new Realm(configuration);
 
-const { useQuery, RealmProvider, useRealm } = createRealmContext(configuration);
+const { useQuery, useObject, RealmProvider, useRealm } = createRealmContext(configuration);
 
 enum QueryType {
   filtered,
@@ -83,12 +83,12 @@ enum QueryType {
   normal,
 }
 
-const App = ({ queryType = QueryType.normal }) => {
+const App = ({ queryType = QueryType.normal, useUseObject = false }) => {
   return (
     <RealmProvider>
       <SetupComponent>
         <View testID="testContainer">
-          <TestComponent queryType={queryType} />
+          <TestComponent queryType={queryType} useUseObject={useUseObject} />
         </View>
       </SetupComponent>
     </RealmProvider>
@@ -113,16 +113,24 @@ const SetupComponent = ({ children }: { children: JSX.Element }): JSX.Element |
   return children;
 };
 
+const UseObjectItemComponent: React.FC<{ item: Item & Realm.Object }> = React.memo(({ item }) => {
+  // Testing that useObject also works and properly handles renders
+  const localItem = useObject(Item, item.id);
+  if (!localItem) {
+    return null;
+  }
+  return <ItemComponent item={localItem}></ItemComponent>;
+});
+
 const ItemComponent: React.FC<{ item: Item & Realm.Object }> = React.memo(({ item }) => {
   itemRenderCounter();
   const realm = useRealm();
   const renderItem = useCallback(({ item }) => <TagComponent tag={item} />, []);
-
   const keyExtractor = useCallback((item) => `tag-${item.id}`, []);
 
   return (
     <View testID={`result${item.id}`}>
-      <View testID={`name${item.id}`}>
+      <View testID={`name${item.name}`}>
         <Text>{item.name}</Text>
       </View>
       <TextInput
@@ -169,7 +177,7 @@ const TagComponent: React.FC<{ tag: Tag & Realm.Object }> = React.memo(({ tag })
 const FILTER_ARGS: [string] = ["id < 20"];
 const SORTED_ARGS: [string, boolean] = ["id", true];
 
-const TestComponent = ({ queryType }: { queryType: QueryType }) => {
+const TestComponent = ({ queryType, useUseObject }: { queryType: QueryType; useUseObject: boolean }) => {
   const collection = useQuery(Item);
 
   const result = useMemo(() => {
@@ -183,7 +191,10 @@ const TestComponent = ({ queryType }: { queryType: QueryType }) => {
     }
   }, [queryType, collection]);
 
-  const renderItem = useCallback(({ item }) => <ItemComponent item={item} />, []);
+  const renderItem = useCallback(
+    ({ item }) => (useUseObject ? <UseObjectItemComponent item={item} /> : <ItemComponent item={item} />),
+    [useUseObject],
+  );
 
   const keyExtractor = useCallback((item) => item.id, []);
 
@@ -201,21 +212,26 @@ function getTestCollection(queryType: QueryType) {
   }
 }
 
-async function setupTest(queryType: QueryType) {
-  const renderResult = render(<App queryType={queryType} />);
+type setupOptions = {
+  queryType?: QueryType;
+  useUseObject?: boolean;
+};
+
+const setupTest = async ({ queryType = QueryType.normal, useUseObject = false }: setupOptions) => {
+  const renderResult = render(<App queryType={queryType} useUseObject={useUseObject} />);
   await waitFor(() => renderResult.getByTestId("testContainer"));
 
   const collection = getTestCollection(queryType);
   expect(itemRenderCounter).toHaveBeenCalledTimes(10);
 
   return { ...renderResult, collection };
-}
+};
 
 describe.each`
   queryTypeName | queryType
-  ${"sorted"}   | ${QueryType.sorted}
   ${"normal"}   | ${QueryType.normal}
   ${"filtered"} | ${QueryType.filtered}
+  ${"sorted"}   | ${QueryType.sorted}
 `("useQueryRender: $queryTypeName", ({ queryType }) => {
   beforeEach(() => {
     testRealm = new Realm(configuration);
@@ -234,7 +250,7 @@ describe.each`
     expect(itemRenderCounter).toHaveBeenCalledTimes(10);
   });
   it("change to data will rerender", async () => {
-    const { getByTestId, getByText, collection } = await setupTest(queryType);
+    const { getByTestId, getByText, collection } = await setupTest({ queryType });
 
     const firstItem = collection[0];
     const id = firstItem.id;
@@ -246,9 +262,10 @@ describe.each`
 
     fireEvent.changeText(input as ReactTestInstance, "apple");
 
-    // TODO: This line throws an `act` warning.  Keep an eye on this issue and see if there's a solution
-    // https://github.com/callstack/react-native-testing-library/issues/379
-    await waitFor(() => getByText("apple"));
+    // Wait for change events to finish their callbacks
+    await act(async () => {
+      forceSynchronousNotifications(testRealm);
+    });
 
     expect(nameElement).toHaveTextContent("apple");
     expect(itemRenderCounter).toHaveBeenCalledTimes(11);
@@ -257,7 +274,7 @@ describe.each`
   // TODO:  This is a known issue that we have to live with until it is possible
   // to retrieve the objectId from a deleted object in a listener callback
   it.skip("handles deletions", async () => {
-    const { getByTestId, collection } = await setupTest(queryType);
+    const { getByTestId, collection } = await setupTest({ queryType });
 
     const firstItem = collection[0];
     const id = firstItem.id;
@@ -277,7 +294,7 @@ describe.each`
     expect(itemRenderCounter).toHaveBeenCalledTimes(11);
   });
   it("an implicit update to an item in the FlatList view area causes a rerender", async () => {
-    const { collection } = await setupTest(queryType);
+    const { collection } = await setupTest({ queryType });
 
     testRealm.write(() => {
       collection[0].name = "apple";
@@ -292,7 +309,7 @@ describe.each`
   });
 
   it("does not rerender if the update is out of the FlatList view area", async () => {
-    const { collection } = await setupTest(queryType);
+    const { collection } = await setupTest({ queryType });
 
     testRealm.write(() => {
       const lastIndex = collection.length - 1;
@@ -306,7 +323,7 @@ describe.each`
     expect(itemRenderCounter).toHaveBeenCalledTimes(10);
   });
   it("collection objects rerender on changes to their linked objects", async () => {
-    const { collection, getByText, queryByText, debug } = await setupTest(queryType);
+    const { collection, getByText, queryByText } = await setupTest({ queryType });
 
     // Insert some tags into visible Items
     testRealm.write(() => {
@@ -354,4 +371,35 @@ describe.each`
 
     expect(queryByText("756c")).toBeNull();
   });
+  // This replicates the issue https://github.com/realm/realm-js/issues/4375
+  it("will handle multiple async transactions", async () => {
+    const { queryByTestId } = await setupTest({ queryType, useUseObject: true });
+    const performTest = async () => {
+      testRealm.write(() => {
+        testRealm.deleteAll();
+      });
+      let i = 0;
+      while (i < 10) {
+        await new Promise((resolve) => setTimeout(resolve, 10));
+        const id = i;
+        testRealm.write(() => {
+          testRealm.create(Item, { id, name: `${id}` }, Realm.UpdateMode.Modified);
+        });
+        await new Promise((resolve) => setTimeout(resolve, 0));
+        testRealm.write(() => {
+          const item = testRealm.objectForPrimaryKey(Item, id);
+          if (item) {
+            item.name = `${id + 100}`;
+          }
+        });
+        i++;
+      }
+    };
+
+    await act(async () => {
+      await performTest();
+    });
+
+    await waitFor(() => queryByTestId(`name${109}`));
+  });
 });
diff --git a/packages/realm-react/src/cachedCollection.ts b/packages/realm-react/src/cachedCollection.ts
index 4a9d0de352..9cfdf159bf 100644
--- a/packages/realm-react/src/cachedCollection.ts
+++ b/packages/realm-react/src/cachedCollection.ts
@@ -31,6 +31,10 @@ type CachedCollectionArgs<T> = {
    * The {@link Realm.Collection} to proxy
    */
   collection: Realm.Collection<T>;
+  /**
+   * The {@link Realm} instance
+   */
+  realm: Realm;
   /**
    * Callback which is called whenever an object in the collection changes
    */
@@ -63,6 +67,7 @@ type CachedCollectionArgs<T> = {
  */
 export function createCachedCollection<T extends Realm.Object>({
   collection,
+  realm,
   updateCallback,
   objectCache = new Map(),
   isDerived = false,
@@ -77,6 +82,7 @@ export function createCachedCollection<T extends Realm.Object>({
             const col: Realm.Results<T & Realm.Object> = Reflect.apply(value, target, args);
             const { collection: newCol } = createCachedCollection({
               collection: col,
+              realm,
               updateCallback,
               objectCache,
               isDerived: true,
@@ -158,7 +164,15 @@ export function createCachedCollection<T extends Realm.Object>({
   };
 
   if (!isDerived) {
-    cachedCollectionResult.addListener(listenerCallback);
+    // If we are in a transaction, then push adding the listener to the event loop.  This will allow the write transaction to finish.
+    // see https://github.com/realm/realm-js/issues/4375
+    if (realm.isInTransaction) {
+      setImmediate(() => {
+        collection.addListener(listenerCallback);
+      });
+    } else {
+      collection.addListener(listenerCallback);
+    }
   }
 
   const tearDown = () => {
diff --git a/packages/realm-react/src/cachedObject.ts b/packages/realm-react/src/cachedObject.ts
index 14e6f76f97..bfaead4a80 100644
--- a/packages/realm-react/src/cachedObject.ts
+++ b/packages/realm-react/src/cachedObject.ts
@@ -26,6 +26,10 @@ type CachedObjectArgs<T> = {
    * The {@link Realm.Object} to proxy
    */
   object: T | null;
+  /**
+   * The {@link Realm} instance
+   */
+  realm: Realm;
   /**
    * Callback function called whenver the object changes. Used to force a component
    * using the {@link useObject} hook to re-render.
@@ -47,6 +51,7 @@ type CachedObjectArgs<T> = {
  */
 export function createCachedObject<T extends Realm.Object>({
   object,
+  realm,
   updateCallback,
 }: CachedObjectArgs<T>): { object: T | null; tearDown: () => void } {
   const listCaches = new Map();
@@ -75,7 +80,7 @@ export function createCachedObject<T extends Realm.Object>({
           // only the modified children of the list component actually re-render.
           return new Proxy(listCaches.get(key), {});
         }
-        const { collection, tearDown } = createCachedCollection({ collection: value, updateCallback });
+        const { collection, tearDown } = createCachedCollection({ collection: value, realm, updateCallback });
         // Add to a list of teardowns which will be invoked when the cachedObject's teardown is called
         listTearDowns.push(tearDown);
         // Store the proxied list into a map to persist the cachedCollection
@@ -104,7 +109,18 @@ export function createCachedObject<T extends Realm.Object>({
     }
   };
 
-  object.addListener(listenerCallback);
+  // We cannot add a listener to an invalid object
+  if (object.isValid()) {
+    // If we are in a transaction, then push adding the listener to the event loop.  This will allow the write transaction to finish.
+    // see https://github.com/realm/realm-js/issues/4375
+    if (realm.isInTransaction) {
+      setImmediate(() => {
+        object.addListener(listenerCallback);
+      });
+    } else {
+      object.addListener(listenerCallback);
+    }
+  }
 
   const tearDown = () => {
     object.removeListener(listenerCallback);
diff --git a/packages/realm-react/src/useObject.tsx b/packages/realm-react/src/useObject.tsx
index d058d7aadc..57c4ac88b5 100644
--- a/packages/realm-react/src/useObject.tsx
+++ b/packages/realm-react/src/useObject.tsx
@@ -59,6 +59,7 @@ export function createUseObject(useRealm: () => Realm) {
       () =>
         createCachedObject({
           object: realm.objectForPrimaryKey(type, primaryKey) ?? null,
+          realm,
           updateCallback: forceRerender,
         }),
       [type, realm, primaryKey],
diff --git a/packages/realm-react/src/useQuery.tsx b/packages/realm-react/src/useQuery.tsx
index a9b547b562..a9ec3a41a4 100644
--- a/packages/realm-react/src/useQuery.tsx
+++ b/packages/realm-react/src/useQuery.tsx
@@ -56,7 +56,7 @@ export function createUseQuery(useRealm: () => Realm) {
 
     // Wrap the cachedObject in useMemo, so we only replace it with a new instance if `primaryKey` or `type` change
     const { collection, tearDown } = useMemo(
-      () => createCachedCollection({ collection: realm.objects(type), updateCallback: forceRerender }),
+      () => createCachedCollection({ collection: realm.objects(type), realm, updateCallback: forceRerender }),
       [type, realm],
     );