diff --git a/rules-tests/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector/Fixture/fixture.php.inc b/rules-tests/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector/Fixture/fixture.php.inc
index 74b37c7d417..af488905505 100644
--- a/rules-tests/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector/Fixture/fixture.php.inc
+++ b/rules-tests/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector/Fixture/fixture.php.inc
@@ -8,8 +8,6 @@ class Fixture
     {
         $isIt = in_array(strtolower($type), ['$this'], true);
         $isIt = in_array(strtolower($type), ['$this']);
-
-        $isIt = in_array(strtolower($type), ['$this', 'two']);
     }
 }
 
@@ -25,8 +23,6 @@ class Fixture
     {
         $isIt = strtolower($type) === '$this';
         $isIt = strtolower($type) == '$this';
-
-        $isIt = in_array(strtolower($type), ['$this', 'two']);
     }
 }
 
diff --git a/rules-tests/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector/Fixture/negated_in_array.php.inc b/rules-tests/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector/Fixture/negated_in_array.php.inc
new file mode 100644
index 00000000000..8f5cbd03258
--- /dev/null
+++ b/rules-tests/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector/Fixture/negated_in_array.php.inc
@@ -0,0 +1,29 @@
+<?php
+
+namespace Rector\Tests\CodeQuality\Rector\FuncCall\SingleInArrayToCompareRector\Fixture;
+
+class NegatedInArray
+{
+    public function run()
+    {
+        $isIt = ! in_array(strtolower($type), ['$this'], true);
+        $isIt = ! in_array(strtolower($type), ['$this']);
+    }
+}
+
+?>
+-----
+<?php
+
+namespace Rector\Tests\CodeQuality\Rector\FuncCall\SingleInArrayToCompareRector\Fixture;
+
+class NegatedInArray
+{
+    public function run()
+    {
+        $isIt = strtolower($type) !== '$this';
+        $isIt = strtolower($type) != '$this';
+    }
+}
+
+?>
diff --git a/rules-tests/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector/Fixture/skip_multi_data.php.inc b/rules-tests/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector/Fixture/skip_multi_data.php.inc
new file mode 100644
index 00000000000..f75178d3b9a
--- /dev/null
+++ b/rules-tests/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector/Fixture/skip_multi_data.php.inc
@@ -0,0 +1,11 @@
+<?php
+
+namespace Rector\Tests\CodeQuality\Rector\FuncCall\SingleInArrayToCompareRector\Fixture;
+
+class SkipMultiData
+{
+    public function run()
+    {
+        $isIt = in_array(strtolower($type), ['$this', 'two']);
+    }
+}
diff --git a/rules-tests/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector/Fixture/skip_negated_multi_data.php.inc b/rules-tests/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector/Fixture/skip_negated_multi_data.php.inc
new file mode 100644
index 00000000000..8292afba5a3
--- /dev/null
+++ b/rules-tests/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector/Fixture/skip_negated_multi_data.php.inc
@@ -0,0 +1,11 @@
+<?php
+
+namespace Rector\Tests\CodeQuality\Rector\FuncCall\SingleInArrayToCompareRector\Fixture;
+
+class SkipNegatedMultiData
+{
+    public function run()
+    {
+        $isIt = ! in_array(strtolower($type), ['$this', 'two']);
+    }
+}
diff --git a/rules/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector.php b/rules/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector.php
index 229cf7f579f..5e4142c627f 100644
--- a/rules/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector.php
+++ b/rules/CodeQuality/Rector/FuncCall/SingleInArrayToCompareRector.php
@@ -10,6 +10,9 @@
 use PhpParser\Node\Expr\ArrayItem;
 use PhpParser\Node\Expr\BinaryOp\Equal;
 use PhpParser\Node\Expr\BinaryOp\Identical;
+use PhpParser\Node\Expr\BinaryOp\NotEqual;
+use PhpParser\Node\Expr\BinaryOp\NotIdentical;
+use PhpParser\Node\Expr\BooleanNot;
 use PhpParser\Node\Expr\FuncCall;
 use Rector\Core\Rector\AbstractRector;
 use Symplify\RuleDocGenerator\ValueObject\CodeSample\CodeSample;
@@ -59,36 +62,59 @@ public function run()
      */
     public function getNodeTypes(): array
     {
-        return [FuncCall::class];
+        return [BooleanNot::class, FuncCall::class];
     }
 
     /**
-     * @param FuncCall $node
+     * @param BooleanNot|FuncCall $node
      */
     public function refactor(Node $node): ?Node
     {
-        if (! $this->isName($node, 'in_array')) {
+        if ($node instanceof BooleanNot) {
+            if (! $node->expr instanceof FuncCall) {
+                return null;
+            }
+
+            $firstArrayItem = $this->resolveArrayItem($node->expr);
+            if (! $firstArrayItem instanceof ArrayItem) {
+                return null;
+            }
+
+            return $this->processCompare($firstArrayItem, $node->expr, true);
+        }
+
+        $firstArrayItem = $this->resolveArrayItem($node);
+        if (! $firstArrayItem instanceof ArrayItem) {
+            return null;
+        }
+
+        return $this->processCompare($firstArrayItem, $node);
+    }
+
+    private function resolveArrayItem(FuncCall $funcCall): ?ArrayItem
+    {
+        if (! $this->isName($funcCall, 'in_array')) {
             return null;
         }
 
-        if ($node->isFirstClassCallable()) {
+        if ($funcCall->isFirstClassCallable()) {
             return null;
         }
 
-        if (! isset($node->args[1])) {
+        if (! isset($funcCall->args[1])) {
             return null;
         }
 
-        if (! $node->args[1] instanceof Arg) {
+        if (! $funcCall->args[1] instanceof Arg) {
             return null;
         }
 
-        if (! $node->args[1]->value instanceof Array_) {
+        if (! $funcCall->args[1]->value instanceof Array_) {
             return null;
         }
 
         /** @var Array_ $arrayNode */
-        $arrayNode = $node->args[1]->value;
+        $arrayNode = $funcCall->args[1]->value;
         if (count($arrayNode->items) !== 1) {
             return null;
         }
@@ -102,19 +128,28 @@ public function refactor(Node $node): ?Node
             return null;
         }
 
-        if (! isset($node->getArgs()[0])) {
+        if (! isset($funcCall->getArgs()[0])) {
             return null;
         }
 
+        return $firstArrayItem;
+    }
+
+    private function processCompare(ArrayItem $firstArrayItem, FuncCall $funcCall, bool $isNegated = false): Node
+    {
         $firstArrayItemValue = $firstArrayItem->value;
 
-        $firstArg = $node->getArgs()[0];
+        $firstArg = $funcCall->getArgs()[0];
 
         // strict
-        if (isset($node->getArgs()[2])) {
-            return new Identical($firstArg->value, $firstArrayItemValue);
+        if (isset($funcCall->getArgs()[2])) {
+            return $isNegated
+                ? new NotIdentical($firstArg->value, $firstArrayItemValue)
+                : new Identical($firstArg->value, $firstArrayItemValue);
         }
 
-        return new Equal($firstArg->value, $firstArrayItemValue);
+        return $isNegated
+            ? new NotEqual($firstArg->value, $firstArrayItemValue)
+            : new Equal($firstArg->value, $firstArrayItemValue);
     }
 }